Lactate imaging with Hadamard‐encoded slice‐selective multiple quantum coherence chemical‐shift imaging

Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD‐SelMQC‐CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia

“…Tumor models of NHL have a lactate level of ~10 mM as measured in tumor extract experiments (2) and from in vivo experiments with a 10 mM lactate external standard placed adjacent to a human lymphoma xenograft (24). The lipid signal in the tumor after SelMQC filtering can be at the level of 10 mM lactate only when the tumor free lipid concentration is the same as 100% safflower seed oil, an unrealistic condition.…”

“…In addition, since each excitation is volume selective, each slice-encoding repetition adds to the signal-to-noise ratio (SNR) of the entire volume. Recently, this technique was implemented with a small animal scanner to examine a human tumor model in a mouse (24). …”

In vivo1H MRS of WSU‐DLCL2 human non‐Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP

“…Recently, a multi-slice selection sequence combined with multiple quantum coherence has been developed (42). This sequence encodes multi-slices by placing Hadamard-encoded inversion pulses in front of the SelMQC sequence that includes chemical shift imaging within each slice, thus providing accurate localization of Lac without perturbing coherence transfer pathways.…”

Enhancement of spectral editing efficacy of multiple quantum filters in in vivo proton magnetic resonance spectroscopy

“…Multiple quantum filters (MQFs) have been used in in vivo proton magnetic resonance spectroscopy (1H MRS) for the detection of metabolites with coupled spins with effective background suppression [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Starting from the incorporation of the spatial localization technique into the filter design [2,3,17,18], many technical advances have been made to improve the performance of MQFs in vivo.…”