Lactate inhibition of lipolysis in exercising man

Boyd, A. E.; Giamber, S.R.; Mager, Milton; Lebovitz, Harold E.

doi:10.1016/0026-0495(74)90081-x

Cited by 104 publications

(65 citation statements)

References 38 publications

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“…Furthermore, fructose has a lower GI than glucose, but results in higher blood lactate concentrations (Moore et al, 2000). It is possible that higher lactate concentrations compromised fat oxidation following the LGI breakfast through direct inhibition of adipose tissue free fatty acid release (Boyd et al, 1974). Indeed, resting fat oxidation was lower after high fructose compared with high glucose meals in obese adults, despite lower glycemic and insulinemic responses to the high fructose meal (Tittelbach et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of breakfast glycemic index on metabolic responses during rest and exercise in overweight and non-overweight adolescent girls

2011

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Background/Objectives: The metabolic responses to mixed breakfast meals with different glycemic indexes (GI) and their effects on substrate metabolism during exercise in adolescent girls have not been examined. The interaction with weight status also warrants investigation. This study investigated the effect of mixed breakfast meals containing high GI (HGI) or low GI (LGI) carbohydrates on metabolic responses and fat oxidation during rest and exercise in overweight (OW) and non-overweight (NO) adolescent girls. Subjects/Methods: A total of 8 OW and 12 NO adolescent girls consumed an isoenergetic HGI (GI ¼ 73) or LGI (GI ¼ 44) breakfast 120 min before completing a 30-min treadmill walk at 50% V O 2peak . Results: Peak blood glucose concentration was higher for HGI compared with LGI in OW (P ¼ 0.023), but not NO (P40.05) girls. Blood glucose total area under the curve (TAUC) was 13% higher in HGI compared with LGI in OW (P ¼ 0.006), but only 4% higher in NO (P ¼ 0.072) girls. Plasma insulin data were log e transformed (lninsulin). Plasma lninsulin concentrations were not different between HGI and LGI (P40.05). Peak plasma lninsulin concentration (P ¼ 0.016) and TAUC (P ¼ 0.001) were greater in OW than NO girls. Fat oxidation during postprandial rest and exercise was not different between breakfasts (P40.05). Conclusions:The elevated glycemic response in HGI compared with LGI was more pronounced in OW girls, suggesting a reduced ability to cope with the metabolic demands of the HGI, but not LGI, breakfast. Manipulation of breakfast GI did not alter fat oxidation during rest or subsequent moderate intensity exercise in OW and NO adolescent girls.

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Section: Discussionmentioning

confidence: 99%

Effect of breakfast glycemic index on metabolic responses during rest and exercise in overweight and non-overweight adolescent girls

2011

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“…The positive correlation between the decrement in plasma NEFA concentration and the increment in glucose utilization is consistent with this hypothesis. Conversely, it is possible that the blunted rise in blood lactate concentration may contribute to impaired suppression of plasma NEFA levels, since lactate is known to inhibit lipolysis [54]. This possibility is supported by a relationship between the increments in blood lactate concentration and the suppression of plasma NEFA levels.…”

Section: Discussionmentioning

confidence: 99%

Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

et al. 1997

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Tissue glucose uptake occurs via a facilitated transport system [1]. The major factors that regulate glucose uptake in vivo are the prevailing plasma glucose and insulin concentrations. Following glucose ingestion the plasma glucose concentration rises, insulin secretion is stimulated and the combination of hyperglycaemia and hyperinsulinaemia contributes to the increase in glucose utilization. Plasma glucose concentration influences glucose utilization by a mass Diabetologia (1997) Summary The ability of hyperglycaemia to enhance glucose uptake was evaluated in 9 non-insulin-dependent (NIDDM), 7 insulin-dependent (IDDM) diabetic subjects, and in 6 young and 9 older normal volunteers. Following overnight insulin-induced euglycaemia, a sequential three-step hyperglycaemic clamp (+ 2.8 + 5.6, and + 11.2 mmol/l above baseline) was performed with somatostatin plus replacing doses of basal insulin and glucagon, 3-3 H-glucose infusion and indirect calorimetry. In the control subjects as a whole, glucose disposal increased at each hyperglycaemic step (13.1 ± 0.6, 15.7 ± 0.7, and 26.3 ± 1.1 m mol/kg ⋅ min). In NIDDM (10.5 ± 0.2, 12.1 ± 1.0, and 17.5 ± 1.1 m mol/kg ⋅ min), and IDDM (11.2 ± 0.8, 12.9 ± 1.0, and 15.6 ± 1.1 m mol/kg ⋅ min) glucose disposal was lower during all three steps (p < 0.05-0.005). Hepatic glucose production declined proportionally to plasma glucose concentration to a similar extent in all four groups of patients. In control subjects, hyperglycaemia stimulated glucose oxidation (+ 4.4 ± 0.7 m mol/kg ⋅ min) only at + 11.2 mmol/l (p < 0.05), while non-oxidative glucose metabolism increased at each hyperglycaemic step (+ 3.1 ± 0.7; + 3.5 ± 0.9, and + 10.8 ± 1.7 m mol/kg ⋅ min; all p < 0.05). In diabetic patients, no increment in glucose oxidation was elicited even at the highest hyperglycaemic plateau (IDDM = + 0.5 ± 1.5; NIDDM = + 0.2 ± 0.6 m mol/kg ⋅ min) and non-oxidative glucose metabolism was hampered (IDDM = + 1.8 ± 1.5, + 3.1 ± 1.7, and + 4.3 ± 1.8; NIDDM = + 0.7 ± 0.6, 2.1 ± 0.9, and + 7.0 ± 0.8 m mol/kg ⋅ min; p < 0.05-0.005). Blood lactate concentration increased and plasma non-esterified fatty acid (NEFA) fell in control (p < 0.05) but not in diabetic subjects. The increments in blood lactate were correlated with the increase in non-oxidative glucose disposal and with the decrease in plasma NEFA. In conclusion: 1) the ability of hyperglycaemia to promote glucose disposal is impaired in NIDDM and IDDM; 2) stimulation of glucose oxidation and non-oxidative glucose metabolism accounts for glucose disposal; 3) both pathways of glucose metabolism are impaired in diabetic patients; 4) impaired ability of hyperglycaemia to suppress plasma NEFA is present in these patients. These results suggest that glucose resistance, that is the ability of glucose itself to promote glucose utilization, is impaired in both IDDM and NIDDM patients. [Diabetologia (1997) 40: 687-697] Keywords Hyperglycaemia, mass action effect, glucose-mediated glucose metabolism, glucose oxidation, non-oxidative glucose metabol...

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“…These, in turn, have been linked to several processes that contribute to fatigue, including the accelerated breakdown of creatine phosphate (McCann, Mollé, & Caton, 1995), the inhibition of glycolysis and glycogenolysis (Spriet, Lindinger, McKelvie, Heigenhauser, & Jones, 1989), the inhibition of lipolysis (Boyd, Giamber, Mager, & Lebovitz, 1974) and the interference with the calcium triggering of muscle contractions (Favero, Zable, Bowman, Thompson, & Abramson, 1995). In addition, lactic acidosis stimulates the release of catecholamines (Goldsmith, Iber, McArthur, & Davies, 1990), and thus the lactate threshold has been found to occur in close proximity to a catecholamine threshold (Urhausen, Weiler, Coen, & Kindermann, 1994;Weltman et al, 1994).…”

Section: Domain Of ''Heavy'' Intensitymentioning

confidence: 99%

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Ekkekakis

Hall

Petruzzello

2005

Journal of Sports Sciences

309

325

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A model for systematic changes in patterns of inter-individual variation in affective responses to physical activity of varying intensities is presented, as a conceptual alternative to the search for a global dose -response curve. It is theorized that trends towards universality will emerge in response to activities that are either generally adaptive, such as moderate walking, or generally maladaptive, such as strenuous running that requires anaerobic metabolism and precludes the maintenance of a physiological steady state. At the former intensity the dominant response will be pleasure, whereas at the latter intensity the dominant response will be displeasure. In contrast, affective responses will be highly variable, involving pleasure or displeasure, when the intensity of physical activity approximates the transition from aerobic to anaerobic metabolism, since activity performed at this intensity entails a trade-off between benefits and risks. Preliminary evidence in support of this model is presented, based on a reanalysis of data from a series of studies.

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Lactate inhibition of lipolysis in exercising man

Cited by 104 publications

References 38 publications

Effect of breakfast glycemic index on metabolic responses during rest and exercise in overweight and non-overweight adolescent girls

Effect of breakfast glycemic index on metabolic responses during rest and exercise in overweight and non-overweight adolescent girls

Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

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