Lactate Levels in Bowel Strangulation With Experimental Animal Model

Tanaka, Keiichiro; Hashimoto, Hisashi; Ohki, Takao

doi:10.9738/intsurg-d-13-00211.1

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Lactate is a product of the anaerobic metabolism of glucose ( Tanaka et al, 2015 ). Lactase from ingested lactic acid bacteria may enhance the hydrolysis of lactose to glucose and galactose in the small intestine, which is rapidly absorbed or fermented ( Hove et al, 1999 ).…”

Section: Resultsmentioning

confidence: 99%

Effect of carnosine synthesis precursors in the diet on jejunal metabolomic profiling and biochemical compounds in slow-growing Korat chicken

Promkhun,

Suwanvichanee,

Tanpol

et al. 2023

Poultry Science

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Section: Resultsmentioning

confidence: 99%

Effect of carnosine synthesis precursors in the diet on jejunal metabolomic profiling and biochemical compounds in slow-growing Korat chicken

Promkhun,

Suwanvichanee,

Tanpol

et al. 2023

Poultry Science

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“…On admission, the patient’s lactate level (2.9 mmol/L) did not really correlate with his clinical status nor intraoperative findings. Although increased lactate is associated with strangulated bowel, the level can lag by 8 h [ 5 ]. In terms of imaging modality, CT is the most reliable with the classical whirlpool sign.…”

Section: Discussionmentioning

confidence: 99%

A curious adult case of small bowel volvulus with congenital malrotation

Tan

Sivasuthan

Wong

2022

Journal of Surgical Case Reports

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Intestinal volvulus is defined as a twisting of the bowel on its mesentery. It itself is a rare occurrence, with documented incidence of 1% as the cause of all small bowel obstruction, with further 0.82% of them being associated with intestinal malrotation. The classical radiographic feature described in literatures is the whirlpool sign. We herein report a rare presentation of congenital malrotation causing a small bowel obstruction in a 43-year-old man. The patient presented with acute abdominal pain and underwent an emergency laparotomy and resection of small and large bowel (total of 3 m with primary anastomosis), with an estimated 2.6 m of viable small bowel left. The patient had a prolonged recovery complicated by another relook operation, superior mesenteric vein thrombus and a high-output stoma with subsequent electrolyte derangements and acute kidney injury. He was discharged on Day 26 and had been seen in the outpatient department with good functionality.

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“…During conditions of ischemic hypoxia, such as bowel ischemia, oxygen-deprived cells will adopt anaerobic glycolysis, and the level of serum lactate will rise [ 8 , 11 ]. Studies have suggested its potential as a biomarker of intestinal ischemia [ 12 , 13 ], and the World Society of Emergency Surgery (WSES) guidelines for the management of acute mesenteric ischemia state that while no laboratory parameters are sufficiently accurate to conclusively identify ischemic bowel, elevated L-lactate may assist [ 14 ]. This study aimed to evaluate the utility of serum L-lactate as a predictor of bowel ischemia in patients with intestinal obstruction.…”

Section: Introductionmentioning

confidence: 99%

Utility of Serum L-lactate in Identifying Ischemia in Acute Intestinal Obstruction: A Prospective Observational Study

Moncy¹,

Kavalakat²,

Vikraman³

2023

Cureus

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Introduction In cases of intestinal obstruction, increasing luminal dilatation compromises bowel wall perfusion, eventually resulting in intestinal ischemia and bowel necrosis in advanced cases. Elevated L-lactate, as a biomarker of ischemia, may indicate the presence of bowel ischemia in cases of obstruction. The objective of this study was to evaluate the value of serum L-lactate measurement in predicting the presence of intraoperatively observed intestinal ischemia in patients with acute intestinal obstruction. Methods Patients diagnosed with acute intestinal obstruction were prospectively studied over an 18-month period. Serum L-lactate values were assayed twice: at the time of presentation and following appropriate fluid resuscitation. Receiver operating characteristic (ROC) curve analysis was applied to determine the predictive value of serum L-lactate in detecting intestinal ischemia. Results One hundred forty-four cases of intestinal obstruction were included in this study, of which 91 underwent operative intervention. Intestinal ischemia was identified in 52 cases and categorized intra-operatively as reversible (n = 33) and irreversible (n = 19). ROC analysis showed a good predictive value of serum L-lactate after fluid resuscitation for irreversible intestinal ischemia (area under the curve (AUC) = 0.884, 95% confidence interval (CI), 0.812-0.956). An L-lactate cut-off of 19.1 mg/dL following fluid resuscitation was determined to have a sensitivity of 89.5%, a specificity of 72.9%, a positive predictive value of 46.6%, and a negative predictive value of 96.3% for gangrenous bowel. Conclusion Serum L-lactate is a good predictive tool for identifying intestinal ischemia during the management of intestinal obstruction. Serum L-lactate after resuscitation showed better predictive value for ischemic bowel.

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Lactate Levels in Bowel Strangulation With Experimental Animal Model

Cited by 7 publications

References 15 publications

Effect of carnosine synthesis precursors in the diet on jejunal metabolomic profiling and biochemical compounds in slow-growing Korat chicken

Effect of carnosine synthesis precursors in the diet on jejunal metabolomic profiling and biochemical compounds in slow-growing Korat chicken

A curious adult case of small bowel volvulus with congenital malrotation

Utility of Serum L-lactate in Identifying Ischemia in Acute Intestinal Obstruction: A Prospective Observational Study

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