Lactate Metabolism in Rat Lung Tissue

Lactate production in isolated perfused rat lung

“…As a result of these observations, it was of interest to Of the studies previously reported using isolated perdetermine whether the increased rate of lactate producfused lung tissue none have investigated the ability of tion under hypoxic conditions would return to the lower lung tissue to produce lactate against an extracellular rate upon aerobic perfusion and to determine the contrilactate concentration approximating its physiological bution of glucose to lactate production under these conlevel. In one study (16) lung slices had been shown to ditions. In the first series of experiments the conversion produce lactate when incubated in media containing 1 of [U-14C]glucose to lactate and the rate of lactate pro-mM lactate.…”

“…AS KNOWLEDGE OF lung metabolism has increased it has become apparent that the lung produces lactate from glucose in significant amounts as measured in a variety of lung tissue preparations from several species (3,4,8,9,12,14,(16)(17)(18). While the status of oxygen availability to the tissue may be questioned in several of these studies, it is qualitatively apparent in all that the lung is capable of net lactate production under the conditions imposed.…”

“…Lactate production under hypoxic conditions has not been previously reported in the isolated perfused lung. However, studies in lung slices (16) have indicated a lOO-200% increase in lactate production under hypoxic conditions. The results presented here likewise provide evidence for an increase of approximately 100%.…”

An MR comparison study of cardiogenic and noncardiogenic pulmonary edema in animal models

“…The lung density in pulmonary lesions is thought to be higher in the CPE group than the NCPE group because the lung volume was significantly smaller in the CPE group than the NCPE group (Table 1). The elevation of lung density might raise the lactate level apparently in the pulmonary lesion of the CPE group because lactate is produced in lung tissue (23). Meanwhile, the BALF might reflect the lungs other than the pulmonary lesions in its lactate level.…”

“…The variety of metabolic change including lactate increases in ARDS (15–22); even in healthy subjects, lactate is higher in the lungs than in other organs (18, 23). The lactate production by lung tissue increases in relation to inflammation (24–26), but it does not increase until the partial pressure of oxygen is less than 0.7 mmHg (27).…”