Lactate signaling and fuel selection in rainbow trout: mobilization of energy reserves
Giancarlo G. M. Talarico,
Elisa Thoral,
Elie Farhat
et al.
Abstract:Lactate is now recognized as a regulator of fuel selection in mammals because it inhibits lipolysis by binding to the hydroxycarboxylic acid receptor 1 (HCAR1). The goals of this study were to quantify the effects of exogenous lactate on: (i) lipolytic rate or rate of appearance of glycerol in the circulation (Ra glycerol) and hepatic glucose production (Ra glucose), and (ii) strategic tissue proteins involved in lactate signaling, glucose transport, glycolysis, gluconeogenesis, lipolysis and β-oxidation in ra… Show more
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