Lactate: the Black Peter in high-risk gastrointestinal surgery patients

Honoré, Patrick M.; Jacobs, Rita; Hendrickx, Inne; Waele, Elisabeth De; Spapen, Herbert D.

doi:10.21037/jtd.2016.03.80

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…It is noteworthy The highest concentration of vitamin C was in the aqueous extracts, which can be attributed to its higher solubility in water. This aligns with previous findings [36], which stated that Vitamin C concentration is higher in aqueous extracts as it is a water-soluble vitamin, also known as ascorbic acid.…”

Section: Evaluation Of Vitamin Csupporting

confidence: 93%

Identification of some Phenolic Compounds of Purslane Extracts (Portulaca Oleraceae L.) and Evaluation its Content from vit.E and vit.C and its Antioxidant Activity in Iraq

Al-Sultani,

Ajeena

2023

IOP Conf. Ser.: Earth Environ. Sci.

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The phenolic compounds present in the four extracts of both stems and leaves of the Portulaca Oleraceae L. were diagnosed using HPLC, and the following observations were made: In the alcoholic extract of the leaves, the highest concentration was found in Gallic acid at 77.89 ppm, followed by other phenolic compounds represented by Quercetin, chlorogenic acid, Ferulic acid, Kemopferol, and p-Coumaric at concentrations of 55.8, 50.22, 40.25, 24.15, and 19.25 ppm, respectively. In the aqueous extract of the leaves, the highest concentration was found in Gallic acid at 62.59 ppm, followed by other phenolic compounds Quercetin, chlorogenic acid, Ferulic acid, p-Coumaric, and Kemopferol at concentrations of 41.25, 40.23, 29.58, 16.25, and 16.22 ppm, respectively. In the alcoholic extract of the stems, it was found to contain four phenolic compounds with Gallic acid having the highest concentration at 40.56 ppm, followed by chlorogenic acid, Quercetin, and Kemopferol at concentrations of 33.65, 30.25, and 14.25 ppm, respectively. In the aqueous extract of the stems, it was found to contain four phenolic compounds with Gallic acid having the highest concentration at 33.69 ppm, followed by Quercetin, chlorogenic acid, and Kemopferol at concentrations of 21.45, 20.58, and 11.48 ppm, respectively. The vitamin C and vitamin E contents were evaluated in the extracts. The highest concentration of vitamin E was found in the aqueous extract of the leaves, followed by the alcoholic extract of the leaves, the aqueous extract of the stems, and the alcoholic extract of the stems, with concentrations of 54.1, 33.5, 31.5, and 25.9 ppm, respectively. As for vitamin C concentration, it was found to be highest in the aqueous extract of the leaves, followed by the aqueous extract of the stems, the alcoholic extract of the leaves, and finally the alcoholic extract of the stems, with concentrations of 85.6, 66.5, 52.8, and 35.6 ppm, respectively. The antioxidant activity of the aqueous and alcoholic extracts of the leaves and stems of Portulaca Oleraceae L. was measured by assessing the removal percentage using the FeCl2 and H2O2 methods. The alcoholic extract of the leaves showed the highest removal percentage of 94.73% at a concentration of 150 mg/ml using the FeCl2 method, and the highest DNA protection percentage of 92.73% at a concentration of 150 mg/ml using the H2O2 method.

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Section: Evaluation Of Vitamin Csupporting

confidence: 93%

Identification of some Phenolic Compounds of Purslane Extracts (Portulaca Oleraceae L.) and Evaluation its Content from vit.E and vit.C and its Antioxidant Activity in Iraq

Al-Sultani,

Ajeena

2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Therefore, serial lactate measurements are essential in the perioperative period. 13 According to our results, the second independent risk factor predicts perioperative lactate elevation was BMI ≥ 30 kg/m 2 . Increased production of circulating fatty acids in obese patients inhibits glucose uptake and leads to hyperlactatemia.…”

Section: Discussionmentioning

confidence: 56%

Risk factors for persistent elevation of perioperative lactate levels in gastric cancer surgery

et al. 2020

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Background: The impact of high-risk surgery on tissue perfusion can be indirectly assessed by measuring lactate levels during surgery and intensive care unit (ICU) stay. While consistently high values are associated with poor prognosis, transient elevations do not mean poor clinical outcomes. Therefore, intraoperative and early postoperative blood lactate monitoring is essential for cancer patients. Aims and Objective: This study aimed to determine the risk factors of persistently elevated lactate levels in the intraoperative and postoperative period in patients with elective gastric cancer surgery. Materials and Methods: We retrospectively enrolled 293 patients who underwent curative resection for gastric cancer. Lactate values of all patients were examined during surgery and ICU-stay at 3rd, 6th, 12th, and 18th hours. All lactate values above 2 mmol/L were considered elevated. The patients were divided into two groups as those with perioperative persistently increased lactate levels and those without. Results: Of the 293 patients, 60 (20.5%) had higher lactate levels in the perioperative period. According to multivariate logistic regression analysis, the operative time had the highest significance rate (p = 0.020) out of two significant variables, followed by the BMI ≥ 30 kg/m2 (p = 0.048). Besides, patients with perioperative hyperlactatemia had prolonged hospital stays (p = 0.034). Conclusions: Operative time and obesity (BMI ≥ 30 kg/m2) were independent risk factors for persistent lactate elevation in the perioperative period. Also, perioperative hyperlactatemia extended the length of hospital stay.

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“…Hyperlactatemia secondary to surgery and associated with the neurohumoral stress response is not uncommon in surgical patients. In operations with prolonged duration, intraoperative 19 In the follow-up of patients after surgery, lactate monitoring is essential. While changes in blood lactate kinetics are significant between 6 and no more thatablen 12 hours between two lactate measurements, it still does not seem possible to estimate the optimal time between two lactate measurements.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting a persistent increase in the perioperative lactate levels in colorectal cancer surgery and its impact on postoperative outcomes

Gülmez

Uzun

Senger

et al. 2020

APIC

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Lactate: the Black Peter in high-risk gastrointestinal surgery patients

Cited by 5 publications

References 19 publications

Identification of some Phenolic Compounds of Purslane Extracts (Portulaca Oleraceae L.) and Evaluation its Content from vit.E and vit.C and its Antioxidant Activity in Iraq

Identification of some Phenolic Compounds of Purslane Extracts (Portulaca Oleraceae L.) and Evaluation its Content from vit.E and vit.C and its Antioxidant Activity in Iraq

Risk factors for persistent elevation of perioperative lactate levels in gastric cancer surgery

Factors affecting a persistent increase in the perioperative lactate levels in colorectal cancer surgery and its impact on postoperative outcomes

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