Lactate: The Mediator of Metabolism and Immunosuppression

Zhang, Yuanyuan; Zhai, Zhao; Duan, Jiali; Wang, Xiangcai; Zhong, Jinghua; Wu, Longqiu; Liu, An; Chen, Miao; Wu, Yanyang; Shi, Huaqiu; Zhong, Jianing; Guo, Zhiyong

doi:10.3389/fendo.2022.901495

Cited by 36 publications

(26 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 32 However, several alternative routes allow HIF-1 activation in presence of oxygen, a phenomenon known as Warburg Effect. 33 , 34 , 35 , 36 , 37 , 38 Many non-hypoxic stimuli are capable of turning on HIF-1, including hormones, growth factors, and microRNAs (miRs), and usually mediate HIF-1α stabilization by targeting PDH2. For instance, Chen et al.…”

Section: Introductionmentioning

confidence: 99%

Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Gambardella¹,

Fiordelisi²,

Cerasuolo³

et al. 2023

iScience

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Gambardella¹,

Fiordelisi²,

Cerasuolo³

et al. 2023

iScience

View full text Add to dashboard Cite

“…The regulation of lactate in the immune microenvironment is also a major means to promote tumour progression. Lactate in the tumour microenvironment can exert the immunosuppressive function, and promote tumour development by inducing, recruiting and regulating immunosuppressive cells 71,72 . Lactate modifies histones and directly inhibits signalling pathways, thus playing an important role in tumour immunity 73–75 .…”

Section: Metabolic Reprogramming During Cancer Developmentmentioning

confidence: 99%

Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer

Wang

Zeng

et al. 2023

Cell Proliferation

View full text Add to dashboard Cite

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the role of a universal metabolic fuel for energy via the ‘lactate shuttle’ moving between cells and transmitting signals. The glycolytic‐dependent metabolism found in tumours and fast‐growing cells has made lactate a pivotal player in energy metabolism reprogramming, which enables cells to obtain abundant energy in a short time. Moreover, lactate can provide favourable conditions for tumorigenesis by shaping the acidic tumour microenvironment, recruiting immune cells, etc. and the recently discovered lactate‐induced lactylation moves even further on pro‐tumorigenesis mechanisms of lactate production, circulation and utilization. As with other epigenetic modifications, lactylation can modify histone proteins to alter the spatial configuration of chromatin, affect DNA accessibility and regulate the expression of corresponding genes. What's more, the degree of lactylation is inseparable from the spatialized lactate concentration, which builds a bridge between epigenetics and metabolic reprogramming. Here, we review the important role of lactate in energy reprogramming, summarize the latest finding of lactylation in tumorigenesis and try to explore therapeutic strategies in oncotherapy that can kill two birds with one stone.

show abstract

“…Lactate level is known to increase when tissue cells are starved for energy and require more oxygen than they can supply, often during extensive exercise and ischemia [ 20 ] ( Figure 2 ). Under the condition of hypoxia, glucose catabolism is mainly carried out through the inefficient energy metabolism pathway glycolysis to produce a large amount of lactate, a.k.a., the Warburg effect, one of the hallmarks of tumors, which makes large amounts of lactate and generates an acidic tumor microenvironment [ 21 ]. These acidic products must be balanced by transport or conversion to other products.…”

Section: Qigong Exercise Balances the Whole Body By Accelerating Mate...mentioning

confidence: 99%

Qigong Exercise Balances Oxygen Supply and Acid-Base to Modulate Hypoxia: A Perspective Platform toward Preemptive Health & Medicine

Zhang

2023

Medical Sciences

View full text Add to dashboard Cite

Qigong is a meditative movement with therapeutic effects and is commonly practiced in Eastern medicine. A growing body of evidence validates its health benefits, leading to mechanistic questions about how it works. We propose a novel mechanism by which the “acid” caused by hypoxia affects metabolism, and the way it is neutralized through Qigong practice involves the body’s blood flow and vasculature modifications. Specifically, Qigong exercise generates an oxygen supply and acid-base balance against the hypoxic effects of underlying pathological conditions. We also propose that Qigong exercise mediated and focused on the local hypoxia environment of tissues might normalize the circulation of metabolic and inflammation accumulation in the tumor tissue and restore the normal metabolism of tissues and cells through calm, relaxation, and extreme Zen-style breathing that gravitates toward preemptive health and medicine. Thus, we propose the mechanisms of action related to Qigong, intending to unify Eastern and Western exercise theory.

show abstract

Lactate: The Mediator of Metabolism and Immunosuppression

Cited by 36 publications

References 88 publications

Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer

Qigong Exercise Balances Oxygen Supply and Acid-Base to Modulate Hypoxia: A Perspective Platform toward Preemptive Health & Medicine

Contact Info

Product

Resources

About