“…*Corresponding Author: Grace Lee, Address: 1117 W. Johnson St., University of Wisconsin, Madison,WI 53706,Email: glee1@wisc.edu,Telephone: (608) Fax: (608) 262-9083.Previous studies have identified altered neurotransmission of gamma-aminobutyric acid (GABA), the principle inhibitory neurotransmitter in the central nervous system (CNS), as supporting maternal physiology and behavior. For example, in the supraoptic nucleus (SON), there is increased clustering of GABA A receptors (Koksma et al, 2005), increased GABAergic synapses (El Majdoubi et al, 1997;Gies and Theodosis, 1994;Kornblatt and Grattan, 2001;Theodosis et al, 1995;Theodosis and Poulain, 2001) and increased GABA release onto oxytocin neurons (de Kock et al, 2003) in lactating versus non-lactating females. Additional brain regions, including the medial preoptic area (MPA) (Kendrick et al, 1992), the bed nucleus of the accessory olfactory tract (BAOT) (Rodriguez et al, 2004), the cingulated cortex (Cg) (Kornblatt and Grattan, 2001), and other hypothalamic areas (Kornblatt and Grattan, 2001), also exhibit altered GABAergic transmission with lactation.…”