Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations

Sharquie, Khalifa E.; Al-Tammimy, Sami M; Al-Mashhadani, Sabeeh A.; Hayani, Raafa K; Al-Nuaimy, Adil A.

doi:10.5070/d3800902vz

Cited by 13 publications

(5 citation statements)

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“…Mouth rinses are easy-to-use oral health products, and their compounds can have diverse benefits on oral health such as antibacterial effects (Polizzi et al 2019), the reduction of aphthous ulcerations (Sharquie et al 2006), or the remineralisation of early carious lesions (Hegazy & Salama 2016). In this study, different acids in the composition of experimental rinse together with 700 ppm F-were evaluated to assess their efficacy against the growth of S. mutans biofilms.…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, other properties of the different acids might be considered. Lactic acid in a mouth rinse has been shown to be good against aphthous ulcers reducing signs and symptoms of the disease in comparison to a placebo (Sharquie et al 2006) or to another mouth rinse (Ibrahim et al 2020). Fumaric acid has also been studied for this purpose as it has been shown to modulate cytokine production in immune cells (Lehmann et al 2007).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm

Koegel,

Braissant,

Waltimo

et al. 2023

Swiss Dent. J. SSO

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This in vitro study assessed the antibacterial effect on Streptococcus mutans biofilms of mouth rinses with 700 ppm F- (derived from NaF) that differed only in their acid compounds (malic, citric, tartaric, fumaric, hydrochloric, phosphoric, and lactic acid) used to adjust pH. S. mutans (ATCC™ 25175) was grown for 22 h at 37°C, harvested, resuspended in simulated body fluid and biofilm formation followed for 24 h at 37°C. Thereafter, biofilms were treated with experimental rinses for 30 s and placed in TAM48 isothermal microcalorimeter at 37°C for 72 h. Applying Gompertz growth model the parameters lag time and growth rate were determined from heat flow curves; additionally, reduction of active biofilms was calculated. Moreover, samples were live/dead-stained and analysed by confocal scanning microscopy. All mouth rinses were showing statistically significant lag time and reduction of active biofilm (p < 0.05, A 19.1 ± 2.3 h and 58.5 ± 7.7%, B 15.5 ± 1.1 h and 41.9 ± 5.3%, C 17.6 ± 1.9 h and 53.1 ± 7.5%, D 18.4 ± 2.4 h and 55.8 ± 8.8%, E 20.2 ± 3.3 h and 61.5 ± 10.0%, F 20.2 ± 3.0 h and 61.6 ± 9.3%, and G 18.3 ± 2.5 h and 55.3 ± 8.9%). Interestingly, there were no differences found between the treated groups (p > 0.05, A 0.064 ± 0.004 1/h, B 0.063 ± 0.005 1/h, C 0.065 ± 0.004 1/h, D 0.067 ± 0.004 1/h, E 0.066 ± 0.006 1/h, F 0.067 ± 0.004 1/h, G 0.066 ± 0.006 1/h) for the maximum growth rate. Vitality staining supported these findings. The present investigation demonstrates that the type of acid compounds used to produce the rinses did not show any negative effect on the antimicrobial properties of the tested products as all of them exhibited a similar efficacy against S. mutans biofilms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm

Koegel,

Braissant,

Waltimo

et al. 2023

Swiss Dent. J. SSO

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“…Furthermore, topical LA is versatile and is used for the treatment of various skin and oral complications such as acne vulgaris, melanogenesis, and recurrent aphthous ulcerations, respectively [247][248][249][250]. An over-the-counter LA containing vaginal douche was assessed for its impact on vaginal microbiota, with adverse findings of 2.6 fold increased risk for acquiring diverse vaginal microbial species through douching with this product during menses [251].…”

Section: Glycerol Monolauratementioning

confidence: 99%

Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility

Archary¹,

Cromarty²

2022

Adv Biomed

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The relationship between inﬂammation and HIV has been a focus of research over the last decade. In HIV-infected individuals, increased HIV-associated immune activation signiﬁcantly correlated to disease progression. While genital inﬂammation (GI) has been shown to signiﬁcantly increase the risk of HIV acquisition and transmission, immune correlates for reduced risk remain limited. In certain HIV-exposed seronegative individuals, an immune quiescent phenotype characterized reduced risk. Immune quiescence is deﬁned by speciﬁc, targeted, highly regulated immune responses that hinder overt inﬂammation or immune activation. Targeted management of inﬂammation, therefore, is a plausible strategy to mitigate HIV risk and slow disease progression. Nonsteroidal anti-inﬂammatory drugs (NSAIDs) such as hydroxychloroquine and aspirin have shown encouraging preliminary results in low-risk women by reducing systemic and genital immune activation. A topical NSAID, containing ibuprofen, is eﬀective in treating vulvovaginal inﬂammation. Additionally, the glucocorticoids (GCs), prednisolone, and dexamethasone are used to treat HIV-associated immune activation. Collectively, these data inform on immune-modulating drugs to reduce HIV risk. However, the prolonged use of these pharmaceutical drugs is associated with adverse eﬀects, both systemically and to a lesser extent topically. Natural products with their reduced side eﬀects coupled with anti-inﬂammatory properties render them viable options. Lactic acid (LA) has immunomodulatory properties. LA regulates the genital microbiome by facilitating the growth of Lactobacillus species, while simultaneously limiting bacterial species that cause microbial dysbiosis and GI.Glycerol monolaurate, besides being anti-inﬂammatory, also inhibited SIV infections in rhesus macaques. The proposed pharmaceutical and natural products could be used in combination with either antiretrovirals for treatment or preexposure prophylaxis for HIV prevention. This review provides a summary on the associations between inﬂammation, HIV risk, and disease progression. Furthermore, we use the knowledge from immune quiescence to exploit the use of pharmaceutical and natural products as strategic interventions to manage inﬂammation, toward mitigating HIV infections.

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“…62 Mouthwash has been used as a vehicle for both herbal or synthetic active ingredients, such as Rosa damascena, 63 Zataria multiflora, essential oils, 64 and lactic acid. 65…”

Section: Mouthrinse/mouthwashmentioning

confidence: 99%

Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis

Suharyani¹,

Mohammed²,

Muchtaridi³

et al. 2021

DDDT

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Recurrent aphthous stomatitis (RAS) is a disease marked by painful oral lesions on the buccal and labial mucosa or tongue. Drug delivery systems (DDS) for RAS include topical forms that manage wound healing, cover the ulcer, and relieve the associated pain. DDS targeting the oral mucosa face a major challenge, especially the short residence times in the mouth due to the effect of “saliva wash-out”, which continually removes the drug. The objective of this review is to study the development of preparation forms and delivery systems of various types and preparations that have been used for RAS management from 1965 until February 2020. There are 20 types of DDS for RAS which were discussed in 62 articles. The preparations were classified into 4 preparation forms: liquid, semi-solid, solid, and miscellaneous. In addition, the ultimate DDS for RAS preparations is the semi-solid forms (41.94%), which include 5 types of DDS are gel, paste, patch, cream, and ointment. This preparation was developed into new preparation form (11.29%), such as adhesive alginates, dentifrice, OraDisc, membranes, bioresorbable plates, pellicles, and gelosomes. Generally, the mucosal drug delivery system is the method of choice in RAS treatment because the ulcer is commonly located in the oral mucosa. In conclusion, these preparations are designed to improve drug delivery and drug activity for the treatment of RAS ulcers. Moreover, almost all of these DDS are topical preparations that use various types of mucoadhesive polymers to increase both residence time in the oral mucosa and pain relief in RAS treatment.

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Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations

Cited by 13 publications

References 0 publications

Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm

Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm

Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility

Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis

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