Lactic Acid as a New Therapeutic Peeling Agent in Melasma

Sharquie, Khalifa E.; AL-TIKREETY, MOHAMMAD M.; Al-Mashhadani, Sabeeh A.

doi:10.1111/j.1524-4725.2005.31035

Cited by 42 publications

(34 citation statements)

References 14 publications

(44 reference statements)

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“…Lactic acid peels have shown some benefit in patients with epidermal melasma, with MASI scores decreasing by almost 57% in Fitzpatrick skin phototype IV patients with no relapse seen at the 6-month follow-up visit in a trial that was not controlled or split-faced in design 66 (level of evidence, II-iii).…”

Section: Alpha Hydroxy Acid Peelsmentioning

confidence: 98%

Melasma: A comprehensive update

Sheth

Pandya

2011

Journal of the American Academy of Dermatology

265

288

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Several methods of treatment are available to patients with melasma. First-line therapy usually consists of topical compounds that affect the pigment production pathway, broad-spectrum photoprotection, and camouflage. Second-line therapy often consists of the addition of chemical peels, although these must be used cautiously in patients with darker skin. Laser and light therapies represent potentially promising options for patients who are refractory to other modalities, but also carry a significant risk of worsening the disease. A thorough understanding of the risks and benefits of various therapeutic options is crucial in selecting the best treatment.

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Section: Alpha Hydroxy Acid Peelsmentioning

confidence: 98%

Melasma: A comprehensive update

Sheth

Pandya

2011

Journal of the American Academy of Dermatology

265

288

View full text Add to dashboard Cite

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“…Fullstrength lactic acid solution (92%; pH 3.5) was used for chemical peel. 8,9 Lactic acid was also used as a sclerosing agent for chemical castration of bulls with 25% scrotal necrosis caused by drug leakage from the testes under the high pressure of injection. 10 Lactic acid in çökelek is less acid than that of apple juice (3.0), vinegar (3.0), and lemon juice (2.0), and none of which burn either our skin or our mouths when the skin and mucosa are intact.…”

Section: Discussionmentioning

confidence: 99%

An Undescribed Scalding, “Çökelek” Burns in Turkish Children: Is Acidic Effect the Reason of High Mortality and Double-Hit Injury?

Çoruh

Doğan

Günay

2007

Journal of Burn Care & Research

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This retrospective review was aimed to evaluate for the first time the risk factors in addition to the demographic and epidemiological features of immersion scalds by hot çökelek in 23 preschool-aged Turkish children younger than 7 years of age, who were admitted to the burn unit of Erciyes University Medical Faculty between January 1996 and August 2006. This retrospective study consisted of 23 hospitalized scalded children by hot çökelek. Hot çökelek burns were studied in terms of age, sex, length of hospital stay, seasonal variation, regions of involvement, the time between burn and admission to our burn unit, extent of burn injury, mortality, morbidity, and treatment modalities. The study consisted of 17 male (74%) and 6 female (26%) pediatric burns with a male-to-female ratio of 2.83:1, which was more frequent in boys. The mean age distribution, extent of burn injury, length of hospital stay, and mean transport time were 3.47 +/- 1.41 (range, 2-6 years), 36.60 +/- 16.60% (range, 12-79%), 26.00 +/- 10.88 (range, 13-38 days), and 8.69 +/- 3.73 (range, 2-15 hours), respectively. The overall mortality rate of the study population was 47.8% (11 of 23 children died). All patients suffered deep partial and full thickness burn injuries and received surgical treatment. Hot çökelek burns with acidic component should be considered important because of its high morbidity and mortality. We emphasize the admittance criteria of patients into burn units need to be reviewed in countries where çökelek is being widely consumed.

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“…α -HAs, such as glycolic acid and lactic acid, have been shown to be effective in treating various types of hyperpigmentary lesions, such as photoaging [36, 37], melasma [38–40], solar lentigines [41, 42], and postinflammatory hyperpigmentation [43]. The proposed mechanism underlying those effects is thought to involve epidermal remodeling and accelerated desquamation, which results in a more rapid and efficient dispersion of existing pigment.…”

Section: Effects Of Has On Pigmentationmentioning

confidence: 99%

Effects of Cosmetic Formulations Containing Hydroxyacids on Sun-Exposed Skin: Current Applications and Future Developments

Kornhauser

Coelho

Hearing

2012

Dermatology Research and Practice

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This paper describes recent data on the effects of various skin formulations containing hydroxyacids (HAs) and related products on sun-exposed skin. The most frequently used classes of these products, such as α- and β-hydroxyacids, polyhydroxy acids, and bionic acids, are reviewed, and their application in cosmetic formulations is described. Special emphasis is devoted to the safety evaluation of these formulations, particularly on the effects of their prolonged use on sun-exposed skin. We also discuss the important contribution of cosmetic vehicles in these types of studies. Data on the effects of HAs on melanogenesis and tanning are also included. Up-to-date methods and techniques used in those explorations, as well as selected future developments in the cosmetic area, are presented.

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Lactic Acid as a New Therapeutic Peeling Agent in Melasma

Abstract: Lactic acid was found to be a new effective and safe peeling agent in the treatment of melasma.

Cited by 42 publications

References 14 publications

Melasma: A comprehensive update

Melasma: A comprehensive update

An Undescribed Scalding, “Çökelek” Burns in Turkish Children: Is Acidic Effect the Reason of High Mortality and Double-Hit Injury?

Effects of Cosmetic Formulations Containing Hydroxyacids on Sun-Exposed Skin: Current Applications and Future Developments

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