Lactic Acid Bacteria and Natural Product Complex Ameliorates Ovalbumin-Induced Airway Hyperresponsiveness in Mice

Nam, Woo Dong; Kim, Hyeonji; Kim, Ji-Soo; Nam, Bora; Bae, Chuhyun; Kim, Joo-Yun; Park, Soo-Dong; Lee, Jung-Lyoul; Sim, Jae-Il

doi:10.1089/jmf.2020.4853

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…Nam et al. (2021), in an OVA‐induced allergic asthma mouse model, observed increased levels of cell factors such as IL‐4, IL‐5, and IL‐13 with increased reactive oxygen species. These findings are largely consistent with the significant increases in IL‐4, IL‐5, IL‐10, TNF‐α, and IFN‐γ levels in allergic mice compared to normal mice in this study.…”

Section: Resultsmentioning

confidence: 99%

Lactic acid bacteria and yeast co‐fermented milk alleviate cow milk allergy

Ma,

Miao,

et al. 2024

Journal of Food Science

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Cow milk allergy is one of the common food allergies. Our previous study showed that the allergenicity of fermented milk is lower than that of unfermented skimmed milk in vitro, and the antigenicity of β‐lactoglobulin and α‐lactalbumin in fermented milk was decreased by 67.54% and 80.49%, respectively. To confirm its effects in vivo, allergic BALB/C mice model was used to further study the allergenicity of fermented milk. It was found that compared with the skim milk (SM) group, the intragastrically sensitization with fermented milk had no obvious allergic symptoms and the fingers were more stable: lower levels of IgE, IgG, and IgA in serum, lower levels of plasma histamine and mast cell protein‐1, and immune balance of Th1/Th2 and Treg/Th17. At the same time, intragastrically sensitization with fermented milk increased the α diversity of intestinal microbiota and changed the microbiota abundance: the relative abundance of norank‐f‐Muribaculaceae and Staphylococcus significantly decreased, and the abundance of Lachnospiraceae NK4A136 group, Bacteroides, and Turicibacter increased. In addition, fermented milk can also increase the level of short‐chain fatty acids in the intestines of mice. It turns out that fermented milk is much less allergenicity than SM.Practical ApplicationFermentation provides a theoretical foundation for reducing the allergenicity of milk and dairy products, thereby facilitating the production of low‐allergenic dairy products suitable for individuals with milk allergies.

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Section: Resultsmentioning

confidence: 99%

Lactic acid bacteria and yeast co‐fermented milk alleviate cow milk allergy

Ma,

Miao,

et al. 2024

Journal of Food Science

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“…A study on the HY2782 complex demonstrated amelioration of OVA-induced AHR in mice. Dexamethasone suppressed levels of cytokines, such as IL-4, and immunocytes, such as eosinophils ( Nam et al, 2021 ). Dexamethasone has also been used as a positive control agent.…”

Section: Discussionmentioning

confidence: 99%

“…BALF was collected from mice immediately after euthanasia, as described previously ( Nam et al, 2021 ). Bronchial sections of the sacrificed mice were cut vertically in half.…”

Section: Methodsmentioning

confidence: 99%

“…A previous study confirmed that Lactobacillus casei HY2782 is effective against PM toxicity in human intestinal cells and a Caenorhabditis elegans model ( Kim et al, 2020 ) and could improve lung inflammation in a PM2.5-induced COPD mouse model ( Nam et al, 2020 ). In addition, the HY2782 complex ameliorates ovalbumin (OVA)-induced AHR in mice ( Nam et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus casei HY2782 and Pueraria lobata Root Extract Complex Ameliorates Particulate Matter-Induced Airway Inflammation in Mice by Inhibiting Th2 and Th17 Immune Responses

Jung

Bae

Kim

et al. 2022

Prev. Nutr. Food Sci.

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This study aimed to investigate the effects of Lactobacillus casei HY2782 and Pueraria lobata root extract complex (HY2782 complex) in mitigating airway inflammation resulting from exposure to particulate matter ≤2.5 m in diameter (PM2.5) in an animal model. Chronic inflammatory airway disease is associated with Th2-related cytokines interleukin (IL)-4, IL-5, and IL-13 and Th17-related cytokine IL-17A, which are the major contributors to allergy and asthma. Results indicated that PM2.5 elevates allergen-related airway inflammation and respiratory hyperresponsiveness in C57BL/6 mice. The HY2782 complex significantly reduced Th2/Th17-derived cytokines IL-4, IL5, IL-13, and IL-17A; immunoglobulin E; and leukotriene C4 in bronchoalveolar lavage fluid (BALF) and serum. Furthermore, the HY2782 complex was associated with the modulation of oxidative stress-related genes. Administration of the HY2782 complex resulted in a markedly reduced number of neutrophils and eosinophil infiltration in BALF. Histopathological observation of lung tissue also showed reduced inflammatory cell infiltration into airways and surrounding tissue. The HY2782 complex may be a promising candidate for the preventive therapy of allergic diseases and airway inflammation caused by PM2.5 inhalation.

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A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

Shen,

Fang,

Tsai

et al. 2024

Probiotics & Antimicro. Prot.

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Chronic obstructive pulmonary disease (COPD) is the world's leading lung disease and lacks effective and specific clinical strategies. Probiotics are increasingly used to support the improvement of the course of inflammatory diseases. In this study, we evaluated the potential of a lactic acid bacteria (LAB) combination containing Limosilactobacillus reuteri GMNL-89 and Lacticaseibacillus paracasei GMNL-133 to decrease lung inflammation and emphysema in a COPD mouse model. This model was induced by intranasal stimulation with elastase and LPS for 4 weeks, followed by 2 weeks of oral LAB administration. The results showed that the LAB combination decreased lung emphysema and reduced inflammatory cytokines (IL-1β, IL-6, TNF-α) in the lung tissue of COPD mice. Microbiome analysis revealed that Bifidobacterium and Akkermansia muciniphila, reduced in the gut of COPD mice, could be restored after LAB treatment. Microbial α-diversity in the lungs decreased in COPD mice but was reversed after LAB administration, which also increased the relative abundance of Candidatus arthromitus in the gut and decreased Burkholderia in the lungs. Furthermore, LAB-treated COPD mice exhibited increased levels of short-chain fatty acids, specifically acetic acid and propionic acid, in the cecum. Additionally, pulmonary emphysema and inflammation negatively correlated with C. arthromitus and Adlercreutzia levels. In conclusion, the combination of L. reuteri GMNL-89 and L. paracasei GMNL-133 demonstrates beneficial effects on pulmonary emphysema and inflammation in experimental COPD mice, correlating with changes in gut and lung microbiota, and providing a potential strategy for future adjuvant therapy.

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Lactic Acid Bacteria and Natural Product Complex Ameliorates Ovalbumin-Induced Airway Hyperresponsiveness in Mice

Cited by 4 publications

References 39 publications

Lactic acid bacteria and yeast co‐fermented milk alleviate cow milk allergy

Lactic acid bacteria and yeast co‐fermented milk alleviate cow milk allergy

Lactobacillus casei HY2782 and Pueraria lobata Root Extract Complex Ameliorates Particulate Matter-Induced Airway Inflammation in Mice by Inhibiting Th2 and Th17 Immune Responses

A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

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