Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans

Abstract

Some probiotic strains are potent inducers of regulatory cells, while others are not. The clear differences between strains imply that an in vitro characterization of probiotic strains before application is recommended.

Dual Role of Toll-Like Receptors in Asthma and Chronic Obstructive Pulmonary Disease

“…Probiotics in the form of Gram-positive bacteria contain TLR ligands and can thus potentiate a TLR driven response as well as shifting the balance from a Th2 response to a Th1 response. Probiotics have been shown to differentially induce a regulatory T-cell response in humans (de Roock et al, 2010;Fink, 2010) and induce the expression of FoxP3 in intestinal lamina propria cells in a murine asthma model (Hong et al, 2010). It has been stated that there is substantial evidence from clinical studies to suggest a role of probiotics in the prevention and management of allergy (Kalliomäki et al, 2010;Rijkers et al, 2010).…”

Interaction of Bifidobacterium bifidum LMG13195 with HT29 Cells Influences Regulatory-T-Cell-Associated Chemokine Receptor Expression

“…ϩ regulatory T cells (Treg cells) from naïve precursors (7,10,11,26,44). Since Treg cells can suppress uncontrolled effector responses to self and intraluminal antigens (5), the recruitment or induction of Treg cells by probiotics could have a beneficial effect on allergy and autoimmune diseases.…”

Are vaccination models suitable to determine whether probiotics have beneficial health effects in the general population?

“…In a human peripheral blood mononuclear cells (PBMC) coculture, B. lactis W51, L. acidophilus W55 or L. plantarum W62 or an Escherichia coli control strain differentially increase T-reg number. 31 In this study, L. acidophilus W55 elicited the greatest increase in iT-regs while L. plantarum W62 had no significant effect above PBMC cultured in medium alone. No proliferation of nT-regs was observed.…”