Lactic Acid Chemical Peels as a New Therapeutic Modality in Melasma in Comparison to Jessner's Solution Chemical Peels

Abstract

Lactic acid was found to be an effective and safe peeling agent in the treatment of melasma, and it was as effective as Jessner's solution.

Treatment of Periorbital dark circles: Comparative study of chemical peeling with a combination of trichloroacetic acid and lactic acid versus carboxytherapy

“…Moreover, it has been reported to inhibit tyrosinase enzyme; therefore it was used in the treatment of melasma [20] . It induces the skin-lightening effect through three mechanisms, namely the induction of keratinocytes desquamation and the removal of melanosomes; the inhibition of tyrosinase; and the thickening of the epidermis and the dermis, so that the vasculatures become less visible [21,22] . There are several advantages of the combination of chemical peels: for instance, increasing the depth of skin penetration without increasing the concentration of chemical peels; lowering the treatment's adverse effects such as scarring and permanent depigmentation by using low concentration of the peeling agents; enhancing tissue regeneration; and reducing subsequent recovery time [11] .…”

Gazelle Eye like Facial Melanosis (Clinico-Histopathological Study)

“…Gazelle eye like facial melanosis although is not un common pigmentory problems among Iraqi population but unfortunately often confused and mixed up either with melasma especially dermal type [1][2][3][4][5][6][7][8][9][10][11][12][13] or with frictional melanosis [13][14][15].…”

“…The skin is darkly pigmented thickened In addition there is not uncommon facial pigmentation that is locally known as Gazelle eye like facial melanosis that is commonly encountered in clinical practice but often misdiagnosed and commonly confused with melasma and does not respond to ordinary therapy options for melasma [1][2][3]6,[8][9][10][11][12][13][14].…”

“…It could be defined as chronic disfiguring dermatological disease of females and males ,although much more common among females that appear during the active reproductive period with the presence of provoking factors like hormonal changes and sunlight that induce brown hyperpigmentation of the face .This may take many shapes but much more commonly a butterfly and a mask appearance [6][7][8][9][10][11][12][13].…”

“…The management of this type of facial pigmentation is often very difficult as all bleaching agents might give only temporary relieving effects [1][2][3][6][7][8][9][10][11][12][13][14]16]. Accordingly, we suggest doing deep dermabrasion as an effective mode of therapy for this condition similar to the dermabrasion that could be carried out for dermal melasma which is resistant to the standard treatments [29].…”