Lactic acid fermentation of goji berries (<i>Lycium barbarum</i>) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

Duan, Wenhui; Zhou, Lingxi; Ren, Yilin; Liu, Fei; Xue, Yuzheng; Wang, Fang-Zhou; Lu, Ran; Zhang, Xiao-Juan; Shi, Jin-Song; Xu, Zheng-Hong; Geng, Yan

doi:10.1039/d3fo03324d

Cited by 11 publications

(10 citation statements)

References 55 publications

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“…Indeed, the most predominant metabolite in our study is lactic acid: a result of the fermentation of rice by the LAB group bacteria. Lactic acid is also known to be anti-hypertensive, in addition to being bifidogenic [ 38 , 53 , 54 ]. Fermentation of polysaccharides has shown to produce Betaine, L-carnitine, and amino imidazole all of which upregulate the tyrosine and tryptophan biosynthesis pathways [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health

Anbalagan,

Nandabalan,

Sankar

et al. 2024

Biomolecules

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The eubiotic state of the gut microbiota is primarily brought about by various probiotic species that colonize the gut. It is becoming very clear that the probiotic-metabolite mixtures in the gut luminal milieu is central in establishing cross-kingdom signalling networks to maintain gut-multi-organ axes health. Culturally, different fermented foods and beverages have been regional staples since ancient times, and are known to be enriched with probiotics. However, regional variations including the environment, the staple food source (prebiotics), and fermentation methods, among other factors, influence the fermenting probiotic species. Fermented rice water (FRW), an economical, easy to make, simple beverage is a rich source of synbiotics. Therefore, consumption of fermented rice water allows for the intake of a variety of region-specific live probiotics. The secondary metabolites (postbiotics) present in such symbiotic mixtures may also contribute toward maintaining normal intestinal cellular functions. In this study, we highlight that regional staples such as rice consumed in their fermented form may hold promise in alleviating gut-related diseases. Our results show that simple overnight fermentation of cooked edible rice enables the growth of probiotic bacterial species belonging to the Lactic Acid Bacteria group (Leuconostoc lactis, Weisella confusa, Weisella cibacria, Lactococcus lactis, lactococcus taiwanensis, Lactobacillus fermentum, Lactobacillus nagelii, and Lactobacillus delbrueckii ssp. indicus). Metabolomic analysis of the overnight fermented and over two-nights fermented rice water identified more than 200 postbiotic metabolites. Our results show that postbiotics contributing to energy metabolism, gut-multiorgan axes, and microbial paraprobiotics are enriched in the overnight (~10 h) fermented rice water as compared to the over two-nights fermented rice water. Functional analysis via gene expression studies for nutrient absorption (mct-1 and mct-2) and barrier integrity (occludin and zo-1) reveals significant upregulation of these genes upon FRW treatment of HT29 colon cells. This study is a first-of-its-kind to demonstrate the proof-of-principle that postbiotics of naturally fermented rice water positively modulates colonocyte health.

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Section: Discussionmentioning

confidence: 99%

Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health

Anbalagan,

Nandabalan,

Sankar

et al. 2024

Biomolecules

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“…Unconventional fermented feed has significant effects on the antioxidant capacity of animals as it is rich in antioxidant substances, such as vitamins, polyphenolic compounds, and organic acids, that can effectively remove free radicals in the body, regulate redox balance, enhance antioxidant enzyme activity, and improve the antioxidant capacity of animals [ 164 ]. These antioxidants not only protect cells and tissues from oxidative damage, but also improve animal immunity, reduce the risk of disease, and promote the healthy growth and performance of animals [ 165 ]. The beneficial microbial metabolites and active substances in unconventional fermented feed have the effects of promoting the activity of antioxidant enzymes, directly or indirectly affecting the activity of antioxidant enzymes, and slowing down the occurrence of oxidative stress [ 166 , 167 ].…”

Section: Unconventional Fermented Feed Improves Oxidative Stress By R...mentioning

confidence: 99%

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

Lian,

Shi,

Liang

et al. 2024

Antioxidants

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Unconventional feed, which is abundant in China, contains anti-nutritional factors and toxins; however, these can be greatly reduced with microbial fermentation, thus improving the nutrient content of the feed, enhancing animal appetites, and ultimately significantly improving the intestinal health and growth performance of animals. When oxidative stress occurs, fermented feed can effectively reduce the damage caused by stress to the gastrointestinal tract, accelerate the removal of gastrointestinal abnormalities, improve the ability to resist intestinal stress, and ensure the efficient production of animals. This review introduces the application of unconventional fermented feed in animal production, and expounds upon the function of unconventional fermented feed in animals with oxidative stress symptoms, so as to provide a theoretical reference for the development and application of unconventional fermented feed in antioxidative stress reduction.

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“…Plants 2024, 13, x FOR PEER REVIEW 14 of 24 of various metabolic diseases, including GI tract inflammation [153][154][155], nonalcoholic fatty liver disease [156], alcoholic liver disease [157], and diabetes [149,158,159]. Many studies have shown that LBPs could alleviate cognitive impairment and neuroinflammation caused by high-fat diets [148,160,161].…”

Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

“…Through their complex influence on GI microbial interactions and interactions between microorganisms and their hosts, as well as the exchange and transformation of metabolites, the active ingredients in goji berries actively participate in immune regulation and energy metabolism and modulate neural messaging [ 152 ]. Therefore, they assist in the treatment of various metabolic diseases, including GI tract inflammation [ 153 , 154 , 155 ], nonalcoholic fatty liver disease [ 156 ], alcoholic liver disease [ 157 ], and diabetes [ 149 , 158 , 159 ]. Many studies have shown that LBPs could alleviate cognitive impairment and neuroinflammation caused by high-fat diets [ 148 , 160 , 161 ].…”

Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

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Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.

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Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

Abstract: Juice fermented with lactic acid bacteria (LAB) has received attention due to its health benefits, such as antioxidant, and anti-inflammatory. Previous research on LAB-fermented goji juice mainly focused on exploring...

Cited by 11 publications

References 55 publications

Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health

Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

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