Lactic Acid Production During Rest and After Exercise in Subjects With Various Types of Heart Disease With Special Reference to Congenital Heart Disease 1

Hallock, Phillip

doi:10.1172/jci101053

Cited by 14 publications

(2 citation statements)

References 3 publications

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“…A tendency toward hyperlactacidemia of arm venous blood in some heart failure patients was recently found by Cotes (15) ; it had previously been noted in an occasional patient (2,16) or not found to any significant extent (17,18), but the validity of methods in the earlier studies is now somewhat questionable. Resting concentrations of lactate in arterial blood shown in Table I averaged significantly higher in the heart failure group than in normal persons.…”

Section: Blood Lactate and Pyruvatementioning

confidence: 89%

The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. I. Relationship to Oxygen Consumption and Cardiac Output, and the Effect of Congestive Heart Failure1

Huckabee¹,

Judson²

1958

J. Clin. Invest.

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Section: Blood Lactate and Pyruvatementioning

confidence: 89%

The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. I. Relationship to Oxygen Consumption and Cardiac Output, and the Effect of Congestive Heart Failure1

Huckabee¹,

Judson²

1958

J. Clin. Invest.

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“…Ab normally elevated arterial lactate levels after exercise have been observed previously in patients with cyanotic congenital heart disease [Hallock, 1939;H avel, 1950], This may be because of the diminished oxygen con tent and saturation of the arterial blood during exercise. Cardiac outputs could not be measured in the present studies because of the right to left shunts in cyanotic patients.…”

Section: Blood Lactate and Pyruvate During Stressmentioning

confidence: 78%

Myocardial Metabolism in Cyanotic Congenital Heart Disease

Scheuer¹,

Shaver²,

Kroetz³

et al. 1970

Cardiology

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Eight normal subjects and 7 cyanotic patients, 5 with tetralogy of Fallot, and 2 with Eisenmenger’s syndrome, were studied with coronary sinus catheterization. In the resting state mean coronary flows were lower and myocardial oxygen extractions higher in cyanotic patients so that myocardial oxygen consumption was the same in the 2 groups. Coronary flows appeared to be inversely related to hematocrit in the cyanotic group. Myocardial lactate balance was similar in the 2 groups, but coronary sinus lactate/ pyruvate ratios were frequently higher than arterial ratios in the cyanotic group. The subjects were stressed with supine leg exercise or with an isoproterenol infusion. In cyanotic subjects exercise caused a fall in arterial oxygen and myocardial oxygen extraction so that oxygen delivery tended to be more dependent upon coronary flow. Myocardial oxygen delivery appeared adequate during stress in cyanotic patients and lactate and pyruvate analysis failed to show evidence of myocardial hypoxia. Between the 3rd and 8th min of exercise, cyanotic patients continued to have falling arterial oxygen values and rising arterial lactate and lactate/pyruvate ratios indicating that they had not reached steady metabolic state. Myocardial glucose and free fatty acid uptake were similar in the 2 groups. These results indicate that although the mechanisms of oxygen delivery to the myocardium may differ in normals and some patients with cyanotic congenital heart disease, left ventricular myocardial oxidative metabolism is intact even in the presence of hypoxemia.

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Pathophysiologie der Herzinsuffizienz

Schwiegk¹,

Riecker²

1960

Herzinsuffizienz Pathophysiologie·Pathologie·Therapie

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Lactic Acid Production During Rest and After Exercise in Subjects With Various Types of Heart Disease With Special Reference to Congenital Heart Disease 1

Cited by 14 publications

References 3 publications

The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. I. Relationship to Oxygen Consumption and Cardiac Output, and the Effect of Congestive Heart Failure1

The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. I. Relationship to Oxygen Consumption and Cardiac Output, and the Effect of Congestive Heart Failure1

Myocardial Metabolism in Cyanotic Congenital Heart Disease

Pathophysiologie der Herzinsuffizienz

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