Lactic Dehydrogenase Activity in Pleural and Peritoneal Effusions

Kirkeby, Knut; Prydz, H

doi:10.3109/00365515909060432

Cited by 24 publications

(8 citation statements)

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“…23 In our study, simultaneous use of these three tests failed to perform as well as in Light's study ( Table 2). The compartmentalised elevation of LDH concentration in the exudative processes may explain why the LDHr has no role in the diagnostic separation of PE into transudate and exudate, 29,35 and why when this parameter is used to separate an exudate from a transudate the sensitivity decreases, as also showed in more recent humans studies. 3e5 Although RBCs contain a large amount of LDH, one human study demonstrated no correlation between the pleural fluid LDH level and pleural fluid RBC, 2 while another supported a relationship between RBC and LDH.…”

Section: Discussionmentioning

confidence: 87%

A new approach to pleural effusion in cats: Markers for distinguishing transudates from exudates

Zoia

Slater

Heller

et al. 2009

Journal of Feline Medicine and Surgery

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Classification of pleural effusion (PE) is central to diagnosis. Traditional veterinary classification has distinguished between transudates, modified transudates and exudates. In human medicine PEs are divided into only two categories: transudates and exudates. The aim of this study was to evaluate, in 20 cats presented with PE, paired samples of serum and pleural fluid for the following parameters: Light's criteria (pleural fluid lactate dehydrogenase concentration (LDHp), pleural fluid/serum LDH ratio, pleural fluid/serum total protein ratio (TPr)), pleural fluid total protein, pleural fluid cholesterol concentration, pleural fluid/serum cholesterol ratio (CHOLr), serum-effusion cholesterol gradient (serum cholesterol minus PE cholesterol concentration (CHOLg)), PE total nucleated cells count (TNCCp) and pleural fluid glucose (GLUp). LDHp and TPr were found most reliable when distinguishing between transudates and exudates, with sensitivity of 100% and 91% and specificity of 100%, respectively. When conflict between the clinical picture and laboratory results exists, calculation of CHOLr, CHOLg and TNCCp measurement may help in the classification of the effusion. Measurement of serum albumin (in the case of a transudate) may provide additional information regarding the pathogenesis of the effusion.

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Section: Discussionmentioning

confidence: 87%

A new approach to pleural effusion in cats: Markers for distinguishing transudates from exudates

Zoia

Slater

Heller

et al. 2009

Journal of Feline Medicine and Surgery

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“…But the benign effusions in all 4 series were mainly transudates. Kirkeby and Prydz (18) first suggested that elevated pleural-fluid LDH may be characteristic of all inflammatory . .…”

Section: Discussionmentioning

confidence: 99%

Pleural Effusions: The Diagnostic Separation of Transudates and Exudates

Light¹

1972

Ann Intern Med

1,547

881

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“…This results in the questionable adoption of the same cut-off value for different species (ie, dogs and cats) and for a different anatomical localisation of the effusion (ie, pleural and abdominal effusions). 14 A recent study of 20 cats demonstrated that Light's criteria, with cut-off points for its parameters adapted to the feline species (Table 1), allowed, as in human medicine, 1,[3][4][5][6]15,16 the discrimination of the pathophysiology of pleural effusion (ie, transudates vs exudates) with an accuracy ⩾90%. 17 Using the traditional veterinary classification on the same 20 cats, [12][13][14] the overall accuracy in discriminating the pathophysiological origin of the effusion was only 40%.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of Light’s criteria and albumin gradient in classifying the pathophysiology of pleural effusion formation in cats

Zoia

Drigo

2015

Journal of Feline Medicine and Surgery

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The primary aim of this study was to assess whether human Light's criteria with the cut-off values previously published for cats are useful and superior to the traditional veterinary classification in diagnosing pathophysiology of fluid formation in cats with pleural effusion. The secondary aim was to assess if the albumin gradient (ALBg) is a reliable criterion for differentiating exudates from transudates in patients with pleural effusion thought to be transudative by clinical criteria but identified as exudative by Light's criteria. Nineteen client-owned cats with pleural effusion were studied. The aetiology of the pleural effusion was used to establish the pathophysiology of its formation. Parameters measured or calculated undergoing statistical analysis included Light's criteria, total protein and total nucleated cell count in the pleural effusions, and the ALBg. Based on the pathophysiology of fluid formation there were seven transudates caused by increased hydrostatic pressure and 12 exudates. There was a significant difference in the accuracy of the Light's criteria in correctly classifying origin of the pleural fluid formation compared with the traditional veterinary classification (84% vs 53%). ALBg values were significantly different between transudates and exudates. One of the three transudates misclassified as exudates by Light's criteria was correctly identified as a transudate by the ALBg. In conclusion, pleural effusion should be classified as either a transudate or an exudate using Light's criteria. In cats with pleural effusion thought to be transudative by clinical criteria, but identified as exudative by Light's criteria, the ALBg may further help in correctly differentiating exudates from transudates.

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Lactic Dehydrogenase Activity in Pleural and Peritoneal Effusions

Abstract: Scand J Clin Lab Invest Downloaded from informahealthcare.com by University of Alberta on 12/12/14For personal use only.

Cited by 24 publications

References 1 publication

A new approach to pleural effusion in cats: Markers for distinguishing transudates from exudates

A new approach to pleural effusion in cats: Markers for distinguishing transudates from exudates

Pleural Effusions: The Diagnostic Separation of Transudates and Exudates

Diagnostic value of Light’s criteria and albumin gradient in classifying the pathophysiology of pleural effusion formation in cats

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