Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery

Wiberg-Itzel, Eva; Josephson, Hampus; Wiberg, Nana; Olson, Linus; Winbladh, Birger; Karlsson, Mathias

doi:10.4172/2167-0897.1000204

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…Moreover, neonates delivered by vacuum extraction had both arterial and venous elevated cord blood LDH levels, same as with emergency cesarean section, as compared to those delivered by spontaneous vaginal delivery and elective cesarean section. 15 Furthermore, in our study we observed a significant correlation between low cord blood pH and high LDH levels with NICU admission and neonatal death, more so with cord blood LDH levels. The mean ± SD for cord blood pH and LDH for neonates requiring NICU admission was 7.08 ± 0.14 and 907.46 ± 743.74 U/L respectively and for neonates who expired was 7.00 ± 0.17 and 1770.25 ± 896.34 U/L respectively (p = 0.000).…”

Section: Discussionsupporting

confidence: 55%

“…The normal reference value for LDH taken from umbilical cord arterial blood in a term newborn was < 612 U/L. 15 instrumental delivery and one (0.6%) assisted breech delivery. Of 59 emergency LSCS, 40 (67.8%) were done for fetal distress and 19 (32.2%) for reasons other than fetal distress like non-progress of labor, breech in labor and previous cesarean section scar in labor, etc.…”

Section: Laboratory Measurementsmentioning

confidence: 91%

“…Fetal acidosis results in low Apgar score at birth (< 7), low umbilical cord pH (umbilical artery cord blood pH < 7.24), 14 high umbilical base deficit or high cord blood lactate dehydrogenase levels (> 612U/L). 15 Umbilical cord blood pH has a significant effect on various fetal organ functions, even a minor change in cord blood pH can severely affect organ systems, especially nervous, and cardiovascular system with resultant fetal distress and poor Apgar score at birth. 7 The normal value of umbilical cord arterial blood pH is 7.24 ± 0.07.…”

Section: Introductionmentioning

confidence: 99%

“…16 Another important indicator of neonatal birth asphyxia is cord blood arterial lactate dehydrogenase (LDH) levels. 12 LDH activity is significantly linked to severity of neonatal diseases such as birth asphyxia, 12,15,17,18 HIE, 19 respiratory distress, 20 necrotizing enterocolitis. 21 and NICU admission.…”

Section: Introductionmentioning

confidence: 99%

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Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Kumar

Yadav

2020

Clinical Epidemiology and Global Health

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To know role of cord arterial blood pH and lactate dehydrogenase levels in neonatal outcome assessment. Methods: Present observational study was conducted in Obstetrics and Gynecology department of a rural tertiary center of Northern India over 6 months (July-January 2019) on 155 term (≥37-≤42 weeks) antenatal women with hypertensive disorders of pregnancy fulfilling inclusion criteria. Immediately after delivery, arterial blood sample was drawn from doubly clamped 10-12 cm long umbilical cord in pre-heparinized insulin syringe, which was sent for pH estimation and 0.5 ml in lithium heparin tube for lactate dehydrogenase levels. One-and 5-min neonatal Apgar score was noted by pediatrician. Cord blood pH and lactate levels were then compared with overall neonatal outcome. Statistical analysis was done using SPSS-22 version. Results: Mean values of umbilical cord arterial pH and LDH was 7.2 ± 0.1 and 449.5 ± 562.9 U/L respectively. Significantly low mean cord blood pH (7.03 ± 0.12) and high LDH levels (939.74 ± 781.75 U/L) were observed in neonates of eclamptic mothers (p = 0.00). Mode of delivery had significant effects on cord blood parameters with significantly low pH and elevated LDH levels seen in neonates delivered by emergency LSCS for fetal distress (p < 0.05). Cord blood LDH levels were more significantly associated with NICU admission, neonatal morbidity and mortality. Cord blood LDH was a better predictor of neonatal outcome with 100% sensitivity and 79.73% specificity. Conclusion: Cord arterial blood lactate dehydrogenase levels were better predictor of overall neonatal outcome.

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Section: Discussionsupporting

confidence: 55%

Section: Laboratory Measurementsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Kumar

Yadav

2020

Clinical Epidemiology and Global Health

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“…Pearson’s correlation test for non-parametric data was performed using IBM SPSS statistics 21. An umbilical cord LDH value > 600 U/L was considered as pathologically increased 21 directly after birth while a LDH value > 900 U/L was considered as an pathological elevation in venous samples in term infants included in the Vietnamese setting 8 . If multiple tests were performed from a sample of an included infant, the first value was used for calculating clinical predictive value (sensitivity, specificity, positive and negative predictive value).…”

Section: Methodsmentioning

confidence: 99%

A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care

Halvorsen

Olson

Araújo³

et al. 2019

Sci Rep

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There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson’s correlation test was 0.91 (p < 0.01) and the R 2 = 0.83 between the two methods. The mean LDH (±SD) for the reference method vs. the POC-LDH was 551 (±280) U/L and 552 (±249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.

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Could the Umbilical Cord Suggest the Method of Anesthesia?

ÇELİK¹,

TAMMO²

2023

Bezmialem Science

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Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery

Cited by 4 publications

References 20 publications

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care

Could the Umbilical Cord Suggest the Method of Anesthesia?

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