Lactic Response in Sickle Cell Trait Carriers in Comparison With Subjects With Normal Hemoglobin

Farhang, Sara; Hardy‐Dessources, Marie‐Dominique; Voltaire, Bruno; Etienne‐Julan, Maryse; Hue, Olivier

doi:10.1097/00042752-200303000-00006

Cited by 21 publications

(38 citation statements)

References 27 publications

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“…Second, this may hinder the release of metabolites from the exercising muscles, particularly lactate. Here lies a possible explanation of the lower blood lactate concentrations at the end of exercise reported by several authors for SCT carriers (8,25,54), despite higher muscle lactate production (22).…”

Section: Sctmentioning

confidence: 80%

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Vincent

Féasson

Oyono-Enguéllé

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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The influence of sickle cell trait and/or α-thalassemia on skeletal muscle microvascular network characteristics was assessed and compared with control subjects [hemoglobin (Hb) AA] in 30 Cameroonian residents [10 HbAA, 5 HbAA α-thalassemia (α-t), 6 HbAS, and 9 HbASα-t] matched for maximal work capacity and daily energy expenditure. Subjects performed an incremental exercise to exhaustion and underwent a muscle biopsy. Muscle fiber type and surface area were not different among groups. However, sickle cell trait (SCT) was associated with lower capillary density ( P < 0.05), lower capillary tortuosity ( P < 0.001), and enlarged microvessels ( P < 0.01). SCT carriers had reduced counts of microvessels <5-μm diameter, but a higher percentage of broader microvessels, i.e., diameter >10 μm ( P < 0.05). α-Thalassemia seemed to be characterized by a higher capillary tortuosity and unchanged capillary density and diameter. Thus, while SCT is a priori clinically benign, we demonstrate for the first time that significant remodeling of the microvasculature occurs in SCT carriers. These modifications may possibly reflect protective adaptations against hemorheological and microcirculatory dysfunction induced by the presence of HbS. The remodeling of the microvascular network occurs to a lesser extent in α-thalassemia. In α-thalassemic subjects, increased capillary tortuosity would promote oxygen supply to muscle tissues and might compensate for the lower Hb content often reported in those subjects.

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Section: Sctmentioning

confidence: 80%

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Vincent

Féasson

Oyono-Enguéllé

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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“…Other investigations have reported higher [La] during the last two increments of a graded test (12), but this contrasting result may be explained by a heterogeneous training status and differences in physical fitness between the tested subjects (12). Bile et al (1) and Sara et al (24) noted a significantly lower blood [La] during a ramp exercise test in sedentary and trained AS, respectively. In these studies, AS were carefully matched with a control group for physical activity and physiological performance (1,24).…”

Section: Discussionmentioning

confidence: 99%

“…Bile et al (1) and Sara et al (24) noted a significantly lower blood [La] during a ramp exercise test in sedentary and trained AS, respectively. In these studies, AS were carefully matched with a control group for physical activity and physiological performance (1,24). Based on the "lactate shuttle" mechanism (4, 5), the pathophysiological process involved in the lowered lactate in AS subjects during incremental exercise could be due to both greater uptake by RBCs and greater utilization by muscles.…”

Section: Discussionmentioning

confidence: 99%

“…The physical and physiological behavior of exercising SCT carriers (AS) remains equivocal, and controversial data have been documented. Although the presence of Hb S should result in lower aerobic capacity, most studies have reported similar aerobic performances in AS and controls (1,13,20,24). Impaired O 2 delivery to muscles from AS RBCs during exercise could result in a greater participation of anaerobic metabolism in exercising muscles.…”

mentioning

confidence: 99%

“…This should lead to an earlier rise in blood lactate concentration ([La]) as noted in subjects with abnormal O 2 transport (34). However, most studies matching AS and normal Hb (AA) subjects in terms of both physical performance and physical activity demonstrate lower blood [La] in AS during incremental exercise (1,13,24).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Faster lactate transport across red blood cell membrane in sickle cell trait carriers

Farhang¹,

Connes²,

Hue³

et al. 2006

Journal of Applied Physiology

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Effects of short supramaximal exercise on hemorheology in sickle cell trait carriers

et al. 2006

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This study compared the hemorheological profile at rest and in response to a short supramaximal exercise test between sickle cell trait (SCT) carriers and a control group. Eight SCT carriers and eight control subjects performed a ramp exercise test on a cycle ergometer conducted to maximal oxygen uptake (VO2max). One week later, they performed a supramaximal exercise test consisting of pedaling for 1 min at 110% VO2max. Blood viscosity (eta(b)), plasma viscosity (eta(p)), hematocrit (Hct) and red blood cell (RBC) rigidity were assessed at rest, at the end of exercise and at the 15th, 30th and 60th min of recovery. Exercise increased eta(b), eta(p) and Hct above resting values in both groups and these parameters remained higher until the 15th or 30th min of recovery as compared to resting values. RBC rigidity was unchanged from baseline values in both groups during exercise and recovery. No difference was observed between the two groups for eta(p) and Hct but eta(b) and RBC rigidity were higher in the SCT carriers at every time point compared with the control group. The higher RBC rigidity and eta(b) found in SCT carriers at rest and in response to a brief supramaximal exercise might constitute a risk factor for microcirculatory complications. Indeed, a short supramaximal exercise test may not be completely inoffensive for SCT carriers.

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Lactic Response in Sickle Cell Trait Carriers in Comparison With Subjects With Normal Hemoglobin

Cited by 21 publications

References 27 publications

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Faster lactate transport across red blood cell membrane in sickle cell trait carriers

Effects of short supramaximal exercise on hemorheology in sickle cell trait carriers

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