Lacticaseibacillus rhamnosus Hao9 exerts antidiabetic effects by regulating gut microbiome, glucagon metabolism, and insulin levels in type 2 diabetic mice

Han, Min−Koo; Liao, Wenyan; Dong, Yao; Bai, Chen; Gai, Zhonghui

doi:10.3389/fnut.2022.1081778

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…In the liver and adipose tissue, IL-6 induces insulin resistance due to insulin receptor inhibition and enhances inflammation [32]. The observed results in this study regarding the serum TNF-α and IL-6 levels could be explained by the metabolic disturbances induced by DEXA that led to an insulin resistance state; this was observed in similar animal studies [33,34]. Furthermore, GCs-induced gut dysbiosis promotes the development of a pro-inflammatory state in the host that is associated with the development of metabolic disorders such as diabetes mellitus type 2 [5,35].…”

Section: Discussionsupporting

confidence: 72%

The Effects of Probiotic Bacillus Spores on Dexamethasone-Treated Rats

Inceu,

Neag,

Catinean

et al. 2023

IJMS

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Glucocorticoids are effective anti-inflammatory and immunosuppressive agents. Long-term exposure is associated with multiple metabolic side effects. Spore-forming probiotic bacteria have shown modulatory properties regarding glycolipid metabolism and inflammation. The aim of this study was to evaluate, for the first time, the effects of Bacillus species spores (B. licheniformis, B. indicus, B. subtilis, B. clausii, and B. coagulans) alone and in combination with metformin against dexamethasone-induced systemic disturbances. A total of 30 rats were randomly divided into 5 groups: group 1 served as control (CONTROL), group 2 received dexamethasone (DEXA), group 3 received DEXA and MegaSporeBiotic (MSB), group 4 received DEXA and metformin (MET), and group 5 received DEXA, MSB, and MET. On the last day of the experiment, blood samples and liver tissue samples for histopathological examination were collected. We determined serum glucose, total cholesterol, triglycerides, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), catalase, total antioxidant capacity (TAC), and metformin concentration. DEXA administration caused hyperglycemia and hyperlipidemia, increased inflammation cytokines, and decreased antioxidant markers. Treatment with MSB reduced total cholesterol, suggesting that the administration of Bacillus spores-based probiotics to DEXA-treated rats could ameliorate metabolic parameters.

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Section: Discussionsupporting

confidence: 72%

The Effects of Probiotic Bacillus Spores on Dexamethasone-Treated Rats

Inceu,

Neag,

Catinean

et al. 2023

IJMS

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“…In our study, lactating sows fed an LGG diet increased their Bacteroidetes abundance levels and F/B ratios, consistent with previous findings in mice [ 24 ]. Previous studies also showed that LGG supplementation improved Bacteroides abundance [ 23 ]. Interestingly, in our study, Bacteroides were predominant in both late gestation and lactation periods.…”

Section: Discussionmentioning

confidence: 96%

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

Gao,

Li,

et al. 2024

J Animal Sci Biotechnol

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Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known to improve insulin resistance. However, whether supplementing LGG can improve insulin sensitivity in sows and enhance lactation performance, particularly the early survival of offspring remains unclear. Hence, we explored the effects and mechanisms of supplementing LGG during late gestation and lactation on sow insulin sensitivity, lactation performance, and offspring survival. In total, 20 sows were randomly allocated to an LGG (n = 10) and control group (n = 10). Results In sows, LGG supplementation significantly improved insulin sensitivity during late gestation and lactation, increased feed intake, milk production and colostrum lactose levels in early lactation, and enhanced newborn piglet survival. Moreover, LGG treatment significantly reshaped the gut microbiota in sows, notably increasing microbiota diversity and enriching the relative abundance of insulin sensitivity-associated probiotics such as Lactobacillus, Bifidobacterium, and Bacteroides. Serum metabolite and amino acid profiling in late-gestation sows also revealed decreased branched-chain amino acid and kynurenine serum levels following LGG supplementation. Further analyses highlighted a correlation between mitigated insulin resistance in late pregnancy and lactation by LGG and gut microbiota reshaping and changes in serum amino acid metabolism. Furthermore, maternal LGG enhanced immunity in newborn piglets, reduced inflammation, and facilitated the establishment of a gut microbiota. Conclusions We provide the first evidence that LGG mitigates insulin resistance in sows and enhances offspring survival by modulating the gut microbiota and amino acid metabolism.

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“…Additionally, in mice fed a high-fat diet, treating 10 9 cfu/mL of L. rhamnosus daily significantly reduced the insulin level and fasting blood glucose. It also reduced proinflammatory cytokines such as IL-6 and TNF-a [55].…”

Section: Lactobacillus Rhamnosusmentioning

confidence: 94%

The Influence of Gut Microbial Species on Diabetes Mellitus

Al-Ishaq

Samuel

Büsselberg

2023

IJMS

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Diabetes mellitus (DM) is a metabolic disorder with an alarming incidence rate and a considerable burden on the patient’s life and health care providers. An increase in blood glucose level and insulin resistance characterizes it. Internal and external factors such as urbanization, obesity, and genetic mutations could increase the risk of DM. Microbes in the gut influence overall health through immunity and nutrition. Recently, more studies have been conducted to evaluate and estimate the role of the gut microbiome in diabetes development, progression, and management. This review summarizes the current knowledge addressing three main bacterial species: Bifidobacterium adolescentis, Bifidobacterium bifidum, and Lactobacillus rhamnosus and their influence on diabetes and its underlying molecular mechanisms. Most studies illustrate that using those bacterial species positively reduces blood glucose levels and activates inflammatory markers. Additionally, we reported the relationship between those bacterial species and metformin, one of the commonly used antidiabetic drugs. Overall, more research is needed to understand the influence of the gut microbiome on the development of diabetes. Furthermore, more efforts are required to standardize the model used, concentration ranges, and interpretation tools to advance the field further.

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Lacticaseibacillus rhamnosus Hao9 exerts antidiabetic effects by regulating gut microbiome, glucagon metabolism, and insulin levels in type 2 diabetic mice

Cited by 8 publications

References 35 publications

The Effects of Probiotic Bacillus Spores on Dexamethasone-Treated Rats

The Effects of Probiotic Bacillus Spores on Dexamethasone-Treated Rats

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

The Influence of Gut Microbial Species on Diabetes Mellitus

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