Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice

Kim, Gun-Dong; Eom, Ji-Eun; Kim, Young In; Shin, Dong-Uk; Lim, Kyung Min; Song, Hyeon-Ji; Lim, Eun Yeong; Song, Ju Hye; Kim, Ha-Jung; Jeon, Byeong Yeob; Song, Kyung Hwa; Shin, Hee Soon; Lee, So-Young

doi:10.1016/j.jff.2024.106043

Journal of Functional Foods

2024

DOI: 10.1016/j.jff.2024.106043

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Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice

Gun-Dong Kim,

Ji-Eun Eom,

Young In Kim

et al.

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Cited by 2 publications

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Assessment of the Safety of Lactiplantibacillus plantarum KF511

Kim,

Song,

Eom

et al. 2024

JKFN

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Probiotics are defined as live microorganisms, which, when administered in adequate doses, confer health benefits on the host. With the increased consumption of probiotics, there have been concerns regarding their safety. Therefore, in this study, evaluation of the safety of Lactiplantibiacllus plantarum KF511 (LPKF511) was conducted according to the guidelines of the Ministry of Food and Drug Safety, South Korea. LPKF511 is known to attenuate lung damage and alleviate inflammation. We conducted antimicrobial susceptibility test, a hemolytic test, measurement of cytotoxicity and D-lactate production, and a bile salt hydrolase (BSH) activity test. The results of antimicrobial susceptibility test revealed that LPKF511 was susceptible to 7 antimicrobials recommended by guidelines of the European Food Safety Authority for bacterial susceptibility testing. In addition, LPKF511 exhibited no hemolytic activity, BSH activity, or cytotoxicity against Caco-2 cells. These results support the use of LPKF511 as a health functional food ingredient without safety concerns.

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Assessment of the Safety of Lactiplantibacillus plantarum KF511

Kim,

Song,

Eom

et al. 2024

JKFN

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Gut Microbiota Modulation in the Management of Chronic Obstructive Pulmonary Disease: A Literature Review

Patibandla,

Bhatt,

Lief

et al. 2024

Cureus

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Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice

Cited by 2 publications

References 59 publications

Assessment of the Safety of Lactiplantibacillus plantarum KF511

Assessment of the Safety of Lactiplantibacillus plantarum KF511

Gut Microbiota Modulation in the Management of Chronic Obstructive Pulmonary Disease: A Literature Review

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