Lactobacillus acidophilus CGMCC 878 impacts colorectal cancer in Sprague-Dawley rats through changing the gut microbiota

Rehman, Ata Ur; Khan, Asif Iqbal; Xin, Yi; yousuf, Waleed; Ahmad, Zainal Arifin; Wang, Liang

doi:10.1016/j.medmic.2022.100062

Cited by 4 publications

(3 citation statements)

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“…Clinical potential has also been demonstrated through human studies and animal models, mainly gastrointestinal diseases involving lactose intolerance, irritable bowel syndrome (IBS), functional gastrointestinal disorders, or inflammatory bowel disease, but also extra-intestinal disorders such as hepatic encephalopathy [ 21 , 22 ]. Therapeutic potential such as attenuating carcinogenesis of gastrointestinal (GI) tract has also been found in probiotics such as Lactobacillus acidophilus CGMCC 878, for example [ 23 ]. Moreover, probiotics have gained widespread acceptance in pediatrics, in particular with positive outcomes in dealing with acute infectious diarrhea and preventing antibiotic-associated diarrhea [ 24 , 25 , 26 ].…”

Section: The Narrow Applications Of Probiotics Provide Favorable Circ...mentioning

confidence: 99%

Postbiotics in Human Health: A Narrative Review

Chen

2023

Nutrients

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In the 21st century, compressive health and functional foods are advocated by increasingly more people in order to eliminate sub-health conditions. Probiotics and postbiotics have gradually become the focus of scientific and nutrition communities. With the maturity and wide application of probiotics, the safety concerns and other disadvantages are non-negligible as we review here. As new-era products, postbiotics continue to have considerable potential as well as plentiful drawbacks to optimize. “Postbiotic” has been defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. Here, the evolution of the concept “postbiotics” is reviewed. The underlying mechanisms of postbiotic action are discussed. Current insight suggests that postbiotics exert efficacy through protective modulation, fortifying the epithelial barrier and modulation of immune responses. Finally, we provide an overview of the comparative advantages and the current application in the food industry at pharmaceutical and biomedical levels.

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Section: The Narrow Applications Of Probiotics Provide Favorable Circ...mentioning

confidence: 99%

Postbiotics in Human Health: A Narrative Review

Chen

2023

Nutrients

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“…Recent ndings in animal studies further indicated that L. acidophilus can prevent formation of aberrant crypt foci, reduce pathogenic bacteria such as Clostridium, Ruminococcus, Porphyromonas, and Bacteroides, and more importantly, have a preventive effect in patients with CRC family history. [19,20] L. gallinarum is another Lactobacillus probiotic that has been recently reported in CRC prevention by remodeling gut microbial composition and inhibiting viability of tumor cells. [8] and B.…”

Section: First Generation Probiotics In Crc Preventionmentioning

confidence: 99%

“…Recent findings in animal studies further indicated that L. acidophilus can prevent formation of aberrant crypt foci, reduce pathogenic bacteria such as Clostridium , Ruminococcus , Porphyromonas , and Bacteroides , and more importantly, have a preventive effect in patients with CRC family history. [ 19 , 20 ] L. gallinarum is another Lactobacillus probiotic that has been recently reported in CRC prevention by remodeling gut microbial composition and inhibiting viability of tumor cells. [ 8 ] L. acidophilus , L. gallinarum , and other members of Lactobacillus including L. casei , L. fermentum , L. gasseri , L. johnsonii , L. paracasei , L. plantarum , L. rhamnosus , and L. salivarius have become the most widely used species as probiotics in gastrointestinal cancers.…”

Section: Microbe-based Strategies In Crc Preventionmentioning

confidence: 99%

Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies

Ha,

Zhang,

2023

Chin Med J

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The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis, metabolism, and immune response. The disruption of microbiota, known as dysbiosis, has been implicated in many intestinal diseases, including colorectal cancer (CRC). As the third most common cancer and the second leading cause of cancer-related death worldwide, CRC poses a significant health burden. There is an urgent need for novel interventions to reduce CRC incidence and improve clinical outcomes. Modulating the intestinal microbiota has emerged as a promising approach for CRC prevention and treatment. Current research efforts in CRC probiotics primarily focus on reducing the incidence of CRC, alleviating treatment-related side effects, and potentiating the efficacy of anticancer therapy, which is the key to successful translation to clinical practice. This paper aims to review the traditional probiotics and new interventions, such as next-generation probiotics and postbiotics, in the context of CRC. The underlying mechanisms of probiotic anti-cancer effects are also discussed, including the restoration of microbial composition, reinforcement of gut barrier integrity, induction of cancer cell apoptosis, inactivation of carcinogens, and modulation of host immune response. This paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and immunotherapy. Despite all the promising findings presented in studies, the evaluation of potential risks, optimization of delivery methods, and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

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