Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis

Liu, Tianhao; Li, Xiaoya; Zhang, Chenyang; Zhao, Lin; Li, Xue; Yu, Yusheng; Zhou, Yahong; Xue, Yuzheng

doi:10.1016/j.heliyon.2023.e22572

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Among the changes observed in gut microbiota, the abundance of Dubosiella newyorkensis was sharply increased in both of the sample-supplemented groups (Figure ). The beneficial effects of Dubosiella newyorkensis have been reported in some recent studies, including antiaging, modulating immune tolerance in colitis, and improving hypertension by altering bile acid metabolism . It has also been suggested as a potential probiotic to improve obesity and liver disease.…”

Section: Discussionmentioning

confidence: 97%

“…The beneficial effects of Dubosiella newyorkensis have been reported in some recent studies, including antiaging, 32 modulating immune tolerance in colitis, 33 and improving hypertension by altering bile acid metabolism. 34 It has also been suggested as a potential probiotic to improve obesity and liver disease. Supplementation of FER and DFER in the diet could significantly facilitate the growth of Dubosiella newyorkensis , which might contribute to its antiobesity effect.…”

Section: Discussionmentioning

confidence: 99%

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Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

Koh,

Hsu,

et al. 2024

J. Agric. Food Chem.

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Some thermal degradants of curcuminoids have demonstrated moderate health benefits in previous studies. Feruloyl acetone (FER), recently identified as a thermal degradant of curcumin, has been previously associated with anticancer and antioxidative effects, yet its other capabilities remain unexplored. Moreover, earlier reports suggest that methoxy groups on the aromatic ring may influence the functionality of the curcuminoids. To address these gaps, an animal study was conducted to investigate the antiobesity effects of both FER and its demethoxy counterpart (DFER) on mice subjected to a high-fat diet. The results demonstrated the significant prevention of weight gain and enlargement of the liver and various adipose tissues by both samples. Furthermore, these supplements exhibited a lipid regulatory effect in the liver through the adiponectin/AMPK/SIRT1 pathway, promoted thermogenesis via AMPK/PGC-1α activation, and positively influenced gut-microbial-produced short-chain fatty acid (SCFA) levels. Notably, DFER demonstrated superior overall efficacy in combating obesity, while FER displayed a significant effect in modulating inflammatory responses. It is considered that SCFA may be responsible for the distinct effects of FER and DFER in the animal study. Future studies are anticipated to delve into the efficacy of curcuminoid degradants, encompassing toxicity and pharmacokinetic evaluations.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

Koh,

Hsu,

et al. 2024

J. Agric. Food Chem.

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“…Each of these taxa have been previously identified as inversely associated with obese phenotypes [ 51 , 52 , 53 , 54 , 55 , 56 ]. The utility of these taxa in promoting metabolic health directly has been explored via probiotic potential; supplementation with D. newyorkensis has demonstrated improved endothelial function in mice [ 57 , 58 ], and clinical trials with A. muciniphila have shown improvement in markers of MetS including insulin sensitivity and hypercholesterolemia [ 11 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Polyphenols Support Akkermansia muciniphila Growth via Mediation of the Gastrointestinal Redox Environment

Van Buiten,

Seitz,

Metcalf

et al. 2024

Antioxidants

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Obesity and metabolic dysfunction have been shown to be associated with overproduction of reactive oxygen species (ROS) in the gastrointestinal (GI) tract, which contributes to dysbiosis or imbalances in the gut microbiota. Recently, the reversal of dysbiosis has been observed as a result of dietary supplementation with antioxidative compounds including polyphenols. Likewise, dietary polyphenols have been associated with scavenging of GI ROS, leading to the hypothesis that radical scavenging in the GI tract is a potential mechanism for the reversal of dysbiosis. The objective of this study was to investigate the relationship between GI ROS, dietary antioxidants and beneficial gut bacterium Akkermansia muciniphila. The results of this study demonstrated A. muciniphila to be a discriminant microorganism between lean (n = 7) and obese (n = 7) mice. The relative abundance of A. muciniphila was also found to have a significant negative correlation with extracellular ROS in the GI tract as measured using fluorescent probe hydroindocyanine green. The ability of the dietary antioxidants ascorbic acid, β-carotene and grape polyphenols to scavenge GI ROS was evaluated in tandem with their ability to support A. muciniphila bloom in lean mice (n = 20). While the relationship between GI ROS and relative abundance of A. muciniphila was conserved in lean mice, only grape polyphenols stimulated the bloom of A. muciniphila. Analysis of fecal antioxidant capacity and differences in the bioavailability of the antioxidants of interest suggested that the poor bioavailability of grape polyphenols contributes to their superior radical scavenging activity and support of A. muciniphila in comparison to the other compounds tested. These findings demonstrate the utility of the GI redox environment as a modifiable therapeutic target in the treatment of chronic inflammatory diseases like metabolic syndrome.

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“…Generally, a decrease in microbiome diversity has been a de ning parameter of dysbiosis in several cardiometabolic and in ammatory diseases [6,17,39]. Speci cally, humans with HFpEF have also been shown to have diminished microbiome diversity [40,41] but it remains to be elucidated whether this is a trigger of HFpEF or collateral damage [13]. Noteworthy, in ZSF1 rats cardiac HFpEF characteristics manifest at an age of 12-13 weeks and the disease progresses until the animals show a reduced health at an age of around 32 weeks [22].…”

Section: Discussionmentioning

confidence: 99%

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Guivala,

Bode,

Okun

et al. 2024

Preprint

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Background: Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precursor trimethylamine (TMA) is synthesized by the intestinal microbiome, crosses the intestinal barrier and is metabolized to TMAO by hepatic flavin-containing mono-oxygenase 3 (FMO3). The intricate interactions of microbiome alterations and TMAO in relation to HFpEF manifestation and progression are analyzed here. Methods: Healthy lean (L-ZSF1, n=12) and obese ZSF1 rats with HFpEF (O-ZSF1, n=12) were studied. HFpEF was confirmed by transthoracic echocardiography and detection of N-terminal pro-brain natriuretic peptide (NT-proBNP). TMAO, amino acids and carnitine were measured using mass-spectroscopy. The intestinal epithelial barrier was analyzed by immunohistochemistry and in-vitro impedance measurements. Hepatic FMO3 quantity was determined by Western blot. The fecal microbiome after 8, 13 and 20 weeks was assessed using 16s rRNA amplicon sequencing. Results: Increased levels of TMAO, carnitine (+46%) and the cardiac stress marker NT-proBNP (+25%) as well as a pronounced amino acid imbalance were observed in obese rats with HFpEF. Anatomy and zonula occludens protein density in the intestinal epithelium remained unchanged, but endothelial barrier function was impaired in O-ZSF1. FMO3 was decreased by 20% in the histologically normal livers of O-ZSF1. Alpha diversity, as indicated by the Shannon diversity index, was comparable at eight weeks of age, but decreased when HFpEF manifested in O-ZSF1 at 13 weeks of age. Bray-Curtis dissimilarity (Beta-Diversity) was shown to be effective in differentiating L-ZSF1 from O-ZSF1 at 20 weeks of age. Members of the microbial families Lactobacillaceae, Ruminococcaceae, Erysipelotrichaceae and Lachnospiraceaewere significantly differentially abundant in O-ZSF1 and L-ZSF1 rats. Conclusions: In the ZSF1 HFpEF rat model, increased dietary intake is associated with alterations in gut microbiome composition and bacterial metabolites, an impaired intestinal barrier, and changes in pro-inflammatory and health-predictive metabolic profiles. HFpEF as well as its most common comorbidities obesity and metabolic syndrome and the alterations described here evolve in parallel and are likely to be interrelated and mutually reinforcing. Dietary adaption may have a positive impact on all entities.

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Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis

Cited by 7 publications

References 23 publications

Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

Dietary Polyphenols Support Akkermansia muciniphila Growth via Mediation of the Gastrointestinal Redox Environment

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

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