Lactobacillus casei administration reduces lung injuries in a Streptococcus pneumoniae infection in mice

Effects of a multi-strain probiotic (PrimaLac) on performance and antibody responses to Newcastle disease virus and infectious bursal disease virus vaccination in broiler chickens

“…The observation, although not statistically significant, is in agreement with that of others (Gill et al, 2000). Oral administration of Lactobacillus strains is reported to significantly enhance the IgG response (Maassen et al, 2000), and administration of lactic acid bacteria produced higher levels of anti-pneumococcal serum IgG and bronchoalveolar lavage IgA in mice (Racedo et al, 2006). The antibody isotypes involved were not specifically determined in our study but such a study might shed more light on the underlying mechanisms involved and whether probiotics have a differential effect on IgM and IgG(Y) antibodies.…”

“…Furthermore, probiotics have been used for improving immunity to infections with salmonellas (Perdigón et al, 1990), Candida albicans (Wagner et al, 2000), coccidia (Dallout et al, 2003) and Escherichia coli (Medici et al, 2005). Probiotics have been also reported to stimulate production of natural antibodies (Haghighi et al, 2006) and to reduce lung damage (Racedo et al, 2006).…”

Multispecies Multistrain Probiotic Effects on Calves Development and Health

“…The MMP reduced the number of calves whit distress respiratory and the calves whit therapeutic treatments against diarrhea and respiratory disorders, although had not difference significant. Apart from their positive effects on gastrointestinal infections, probiotic may be used to prevent non intestinal infectious conditions, such as respiratory tract infections [30,31]. The present results indicate that this MMP may reduce the mortality and antibiotic treatment in veterinary practice as was observed by Timmerman et al (2005) [14].…”

Specific Immune Response Induced by a Lactobacillus Associated with a Pneumococcal Antigen in an “in vitro” Human Cells Model

“…There is vast evidence showing that the main mechanism through which probiotics provide health benefits is the modulation of immune functions, an effect that is strain-dependent [8,9]. Lactobacillus casei CRL 431 is a probiotic as well as an immunobiotic [10] strain since it is able to activate the mucosal immune system [8,9,11]. Previous reports have shown that this lactobacillus was able to increase specific anti-pneumococcal IgA and IgG after a respiratory pneumococcal infection in a mouse model.…”

“…Previous reports have shown that this lactobacillus was able to increase specific anti-pneumococcal IgA and IgG after a respiratory pneumococcal infection in a mouse model. In addition, pro-inflammatory TNF-α and regulatory IL-10 cytokines [11] increased when L. casei was preventively administered by the oral and nasal route [11,12]. In the development of vaccines, LAB were used mainly as antigen vehicles [13,14] while there are few studies concerning the use of non-recombinant strains as adjuvants in mucosal vaccine formulations.…”