Lactobacillus crispatus-loaded electrospun fibers yield viable and metabolically active bacteria that kill Gardnerella in vitro

Mahmoud, Mohamed Y.; Wesley, Madeline; Kyser, Anthony J.; Lewis, Warren G.; Lewis, Amanda L.; Steinbach-Rankins, Jill M.; Frieboes, Hermann B.

doi:10.1016/j.ejpb.2023.04.011

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…Given high BV concordance between female sex partners ( 31 , 32 ), transmission of beneficial lactobacilli through WSW sexual networks could yield substantial gains in individual and community health. That said, Lactobacillus LBP research largely focuses on L. crispatus ( 81 , 82 ), which shows substantial genomic, metabolic, and epidemiologic differences to L. iners ( 8 – 10 , 83 , 84 ). Without identifying putative transmission of other lactobacilli, it is unclear how generalizable the observation of L. iners transmission is to possible transmission of Lactobacillus LBP strains.…”

Section: Discussionmentioning

confidence: 99%

Sexual transmission of urogenital bacteria: whole metagenome sequencing evidence from a sexual network study

Carter,

France,

Rutt

et al. 2024

mSphere

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Epidemiologic evidence consistently indicates bacterial vaginosis (BV) is sexually associated and may be sexually transmitted, though sexual transmission remains subject to debate. This study is not capable of demonstrating BV sexual transmission; however, we do provide strain-level metagenomic evidence that strongly supports heterosexual transmission of BV-associated species. These findings strengthen the evidence base that supports ongoing investigations of concurrent male partner treatment for reducing BV recurrence. Our data suggest that measuring the impact of male partner treatment on F. vaginae , G. leopoldii , P. amnii , S. sanguinegens , and S. vaginalis may provide insight into why a regimen does or does not perform well. We also observed a high degree of strain concordance between non-sexual-contact female participants. We posit that this may reflect limited dispersal capacity of vaginal bacteria coupled with individuals’ comembership in regional transmission networks where transmission may occur between parent and child at birth, cohabiting individuals, or sexual contacts.

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