Lactobacillus paracasei from koumiss ameliorates diarrhea in mice via tight junctions modulation

The Probiotic Lactobacillus paracasei Ameliorates Diarrhea Cause by Escherichia coli O8via Gut Microbiota Modulation1

“…Lactobacillus paracasei ( L. paracasei ) is a strain isolated from koumiss. It tolerates low pH, bile salts, simulated gastric secretions and environments, intestinal fluids, and enhanced jejunal TJ ( 30 ). In the present study, we administered L. paracasei to treat E. coli- induced diarrhea and used 16s rRNA analysis to investigate the effects of the probiotic on the gut microbiome.…”

Promising probiotic-fermented soymilk for alleviating acute diarrhea: insights into the microbiome and metabolomics

“…Lactic acid bacteria (LAB) have received increasing attention in recent years because they have displayed immense potential in controlling gastrointestinal infections, constipation, diarrhea, and irritable bowel disease. 6 Meanwhile, food therapy has been proposed as a practical possibility for alleviating some gastrointestinal disorders. People have increasingly realized the potential of plant-based foods to relieve diarrhea and intestinal inflammation.…”

Lactobacillus paracaseiinfluences the gut-microbiota-targeted metabolic modulation of the immune status of diarrheal mice

“…20,[26][27][28][29] Lactobacillus paracasei (L. paracasei) is a potential probiotic previously isolated from Aluke'erqin-fermented sour milk samples, which exhibits favorable properties, including acid, bile, simulated gastric fluid, and simulated intestinal fluid resistance. 30 Oral administration of L. paracasei can modulate tight junction proteins and enhance anti-inflammatory response; 31 however, its role in the metabolism and immune response to diarrhea has not been fully elucidated. The results of this study reveal a potential therapeutic strategy to improve immunity, gut integrity, and microbial diversity, or relieve diarrhea.…”