Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

Abstract

Hair loss is a disease that requires accurate diagnosis and type-specific medical treatment. Many hair loss treatments have some side effects, such as hormone-related effects, so there is a need for safe and effective hair loss treatment. In this study, we investigated the effects of Lactobacillus paracasei HY7015 (HY7015) and Lycopus lucidus Turcz. (LT) extract on hair regrowth and protection. In vitro experiments were conducted to assess the effects of HY7015 and/or LT extract on human follicle dermal papilla cells (HFDPC) of cytoprotective functions such as proliferations, antioxidants, anti-inflammatory, and growth factor expressions. In animal experiments, we investigated hair regrowth rate, hair follicle formation and secretion of growth factors in telogenic C57BL/6 mice. We confirmed the cytoprotective effects of HY7015 and LT through regulations of proliferation, SOD and IL-1β in HFDPC. In mouse experiments, oral administration of HY7015 and LT promoted hair regrowth as well as hair follicle maturation in the dermal skin of C57BL/6 mice, and upregulated VEGF and IGF-1 growth factor levels in mouse serum. In summary, our data demonstrate that ingestions of HY7015 and LT can promote hair regrowth by enhancing cytoprotective effects and expressions of growth factors.

Efficacy of probiotics in hair growth and dandruff control: A systematic review and meta-analysis

“…MG8 gel when compared to the control group. Lee et al [ 61 ] reported increased hair regrowth in mice treated with L. reuteri BM36301. For skin thickness, findings were explored by Song et al [ 58 ] and Baek et al [ 62 ], who suggested positive changes in skin thickness related to their interventions.…”

“…Baek et al (2022) [ 62 ] found Enterococcus faecalis (E. faecalis) EF-2001 may accelerate hair regrowth and follicle maturation. Lee et al (2022) [ 61 ] observed hair regrowth and follicle maturation with L. paracasei HY7015 and Lycopus lucidus Turcz. (LT) administration.…”

“…6 . This outcome was assessed in both RCTs and in vivo animal studies [ 62 , 69 , 72 , 73 ] included in the analysis. Hair regrowth was measured using various methods, including hair count, hair thickness, hair follicle count, skin thickness, VEGF, and IGF-1 parameters.…”

Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

“…Extract of Geranium sibiricum contains gallic acid and corilagin (an ellagitannin) [46]. Extracts of Perilla frutescens and Lycopus lucidus contain rosmarinic acid as the main component [59,71], and extract of Allium ascalonicum contains rosmarinic acid, p-coumaric acid, and quercetin [57]. Rosmarinic acid was shown to attenuate cell death caused by testosterone and promote VEGF gene expression in cells [57,59,71].…”

Protection and Restoration of Damaged Hair via a Polyphenol Complex by Promoting Mechanical Strength, Antistatic, and Ultraviolet Protection Properties

“…Hair dyeing and bleaching have become a recent trend that harms the hair, especially the hair shaft, decreases its mechanical strength, and makes it prone more to breakage [ 1 ]. Moreover, regular dying and/or bleaching of hair causes unfavorable growth patterns, reduced glossiness, and difficulty in management; thus, affecting the visual perception of the hair, which could further impact a person’s confidence level [ 2 , 3 ]. Additionally, habitual usage of a hair drier can cause roughness, dryness, and color loss due to a rapid decrease in hair moisture after exposure to warm air [ 4 ].…”