Simple Summary: Necrotic enteritis is one of the most important economic issues in the poultry industry, associated with sudden death rates of up to 50%. However, there is limited information on the role of probiotics and/or phytobiotic compounds on the treatment and prevention of Clostridium perfringens infections in broiler chicks. This study aimed to assess the effects of probiotic compounds (Maxus, CloStat, Sangrovit Extra, CloStat + Sangrovit Extra and Gallipro Tech) on the growth performance, blood biochemistry and intestinal health of broiler chicks in vivo. The results demonstrated that the inclusion of probiotic and/or phytobiotic compounds has a positive effect on performance, blood constituents, liver histopathology, intestinal morphology and histopathology. Furthermore, a notable reduction in both lesion scores was observed when probiotics and phytobiotics alone or in combination were included in the diets.Abstract: This study evaluated the effects of feed additives on the growth, blood biochemistry and intestinal health of broiler chicks. A total of 378 of broiler chicks (Ross 308) were randomly allotted to seven groups. Chicks were fed a basal diet with 0.0 (control negative), 0.0 (control positive), 0.1, 0.5, 0.12, 0.5 + 0.12 and 0.2 g Kg −1 of Maxus, CloStat, Sangrovit Extra, CloStat + Sangrovit Extra and Gallipro Tech, respectively for 35 days. After 15 days, the chicks were inoculated with Clostridium perfringens. All feed additives were found to enhance growth performance and feed efficiency. The best feed conversion ratio was found in the Negative Control, CloStat + Sangrovit Extra and Gallipro Tect groups, respectively. A notable increase in villus length, total villus area, small intestine weight, ilium weight and total lesion score was found in chicks supplemented with Bacillus subtilis. Besides, the dietary inclusion of phytobiotic compounds showed potential in reducing the serum Alanine aminotransferase (ALT) concentration and increasing the glucose levels. All intestine and liver histopathological signs were reduced in chicks fed a probiotic-supplemented diet. Our findings indicate that supplementation with probiotics and phytobiotics alone or in combined form can be