Lactobacillus Plantarum HFY15 Helps Prevent Retinoic Acid‐Induced Secondary Osteoporosis in Wistar Rats

Liu, Xinhong; Zheng, Jiazhuang; Li, Fang; Yi, Ruokun; Mu, Jianfei; Tan, Fang

doi:10.1155/2020/2054389

Cited by 8 publications

(7 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The suppression of Wnt10b in bone after glucocorticoid treatment was restored by L. reuteri ( Schepper et al, 2020 ), as in the diabetes model described previously. In another model of secondary osteoporosis, in which osteoporosis is induced by vitamin A, Lactobacillus plantarum HFY15 or Lactobacillus fermentum ZS40 isolated from yak yogurt restored BV/TV and other trabecular properties in rats and increased Wnt10b levels in the bone ( Liu et al, 2020d ; Liu et al, 2020f ).…”

Section: Wnt10b and Bonementioning

confidence: 99%

The role of WNT10B in physiology and disease: A 10-year update

Perkins

Singh

Abell

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate decisions. WNT10B plays roles in many tissues, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Aberrant WNT10B signaling leads to several diseases, such as osteoporosis, obesity, split-hand/foot malformation (SHFM), fibrosis, dental anomalies, and cancer. We reviewed WNT10B a decade ago, and here we provide a comprehensive update to the field. Novel research on WNT10B has expanded to many more tissues and diseases. WNT10B polymorphisms and mutations correlate with many phenotypes, including bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. In addition, the field has focused on the regulation of WNT10B using upstream mediators, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). We also discussed the therapeutic implications of WNT10B regulation. In summary, research conducted during 2012–2022 revealed several new, diverse functions in the role of WNT10B in physiology and disease.

show abstract

Section: Wnt10b and Bonementioning

confidence: 99%

The role of WNT10B in physiology and disease: A 10-year update

Perkins

Singh

Abell

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…N., Tb. Th., BMD ↑, the number of OC, Tb spacing ↓ β-Catenin, Wnt10b, Lrp5, Lrp6, Runx2, ALP mRNA expression ↑ , DKK1, RANK, TRAP, CTSK mRNA expression ↓ 176 L. helveticus ATCC 27558 OVX Sprague–Dawley rats Femur BMD, breaking forces, serum OCN ↑ , serum CTX ↓ Runx2 and BMP2 mRNA expression ↑ , Lactobacillus enumeration in the feces ↑ 177 L. curvatus Wikim 38 OVX C57BL/6 mice BV/TV, BMD, Tb. Th.…”

Section: The Prospect Of Probiotics In Osteoporosis Therapymentioning

confidence: 99%

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Lyu¹,

Hu²,

Guo³

et al. 2023

Bone Res

View full text Add to dashboard Cite

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, including probiotics or antibiotics, have been found to affect bone remodeling. This review provides a comprehensive summary of recent research on the role of GM in regulating bone remodeling and seeks to elucidate the regulatory mechanism from various perspectives, such as the interaction with the immune system, interplay with estrogen or parathyroid hormone (PTH), the impact of GM metabolites, and the effect of extracellular vesicles (EVs). Moreover, this review explores the potential of probiotics as a therapeutic approach for OP. The insights presented may contribute to the development of innovative GM-targeted therapies for OP.

show abstract

“…beer, milk products, and meat), dietary supplements, or non-conventional products (toothpaste or ice cream). Recent reports implicated that the intestinal microbiota and physiology may also be important players in the regulation of bone health ( 9 – 15 ). Hence, probiotics, known to modulate the microbiota function and/or composition to improve intestinal health, may also benefit the health of bones.…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Lactobacillus plantarum LP45 inhibits the RANKL/OPG signaling pathway and prevents glucocorticoid-induced osteoporosis

Jiang

Xie

2023

Food & Nutrition Research

View full text Add to dashboard Cite

Objective: To examine the potential effect of the probiotic strain Lactobacillus plantarum LP45 on osteoporosis and to explore the involved molecular mechanisms. Methods: A rat model of glucocorticoid-induced osteoporosis (GIO) was established, which was also orally administered with increasing doses of LP45 for 8 weeks. After the termination of the 8-week treatment, the tibia and femur bones of rats were analyzed for bone histomorphometry, bone mineral content (BMC), and bone mineral density (BMD). Femoral biomechanics were assessed. In addition, levels of osteocalcin, tartrate-resistant acid phosphatase 5 (TRAP5), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-B ligand (RANKL) in the serum and bone marrow were also measured using ELISA, Western blot, and real time-polymerase chain reaction. Results: GIO caused obvious defects in tibia and femur bone structures, in terms of tissue/bone volume, trabecular separation, trabecular thickness, and trabecular number, which could be rescued by LP45 dose dependently. The GIO-induced reductions in BMC, BMD, osteoblast surfaces per bone surface (BS), as well as elevated osteoclast surface per BS were largely restored by LP45 administration dose-dependently. LP45 also increased femoral biomechanics of GIO rats. Importantly, LP45 dose-dependently restored the changes of osteocalcin, TRAP5, OPG, and RANKL in the serum as well as bone marrow of GIO rats. Conclusion: Oral LP45 administration could significantly prevent bone defects in GIO rats, suggesting its potential as a dietary supplement with beneficial effects against osteoporosis, which might involve the RANKL/OPG signaling pathway.

show abstract

Lactobacillus Plantarum HFY15 Helps Prevent Retinoic Acid‐Induced Secondary Osteoporosis in Wistar Rats

Cited by 8 publications

References 61 publications

The role of WNT10B in physiology and disease: A 10-year update

The role of WNT10B in physiology and disease: A 10-year update

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Lactobacillus plantarum LP45 inhibits the RANKL/OPG signaling pathway and prevents glucocorticoid-induced osteoporosis

Contact Info

Product

Resources

About