Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice

Lee, Kippeum; Kim, Ji-Soo; Park, Soo-Dong; Shim, Jae-Jung; Lee, Jung-Lyoul

doi:10.3390/ijms221810023

Cited by 37 publications

(28 citation statements)

References 62 publications

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“…Butyrate is a short-chain fatty acid with anti-inflammatory and anticancer properties, and recent studies have reported an association with sarcopenia [34]. Interestingly, based on the recently published results for ameliorates sarcopenia of HY7715 [35], considering the changes in the butyrate concentration and butyrate-producing bacteria in the HY7715-treated group, the HY7715 intake has the potential to improve sarcopenia, but studies on the interaction between the microbiome and its metabolites should be conducted. Future studies using the simulated gut system require metabolomics-related research to understand comprehensive changes in complex metabolites produced by diverse microbial communities and influenced by their interaction.…”

Section: Discussionmentioning

confidence: 99%

Effects of L. plantarum HY7715 on the Gut Microbial Community and Riboflavin Production in a Three-Stage Semi-Continuous Simulated Gut System

Hong¹,

Yoo²,

Heo³

et al. 2021

Microorganisms

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Probiotics should be well established in the gut, passing through the digestive tract with a high degree of viability, and produce metabolites that improve the gut environment by interacting with the gut microbiome. Our previous study revealed that the Lactiplantibacillus plantarum HY7715 strain shows good bile acid resistance and a riboflavin production capacity. To confirm the interaction between HY7715 and gut microbiome, we performed a metabolite and microbiome study using a simulated gut system (SGS) that mimics the intestinal environment. Changes in the microbiome were confirmed and compared with L. plantarum NCDO1752 as the control. After 14 days, the HY7715 treatment group showed a relatively high butyrate content compared to the control group, which showed increased acetate and propionate concentrations. Moreover, the riboflavin content was higher in the HY7715 treatment group, whereas the NCDO1752 treatment group produced only small amounts of riboflavin during the treatment period and showed a tendency to decrease during the washout stage; however, the HY7715 group produced riboflavin continuously in the ascending colon during the washout period. A correlation analysis of the genus that increased as the content of riboflavin increased revealed butyrate-producing microorganisms, such as Blautia and Flavonifractor. In conclusion, treatment with L. plantarum HY7715 induced the production and maintenance of riboflavin and the enrichment of the intestinal microbiome

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Section: Discussionmentioning

confidence: 99%

Effects of L. plantarum HY7715 on the Gut Microbial Community and Riboflavin Production in a Three-Stage Semi-Continuous Simulated Gut System

Hong¹,

Yoo²,

Heo³

et al. 2021

Microorganisms

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“…Anti-inflammatory, butyrate producer with probiotic effect [120][121][122], its beneficial effects are demonstrated also in CNS (altered behaviors, depression, anxiety, stress, cognitive impairment, andAD models) [123][124][125][126][127][128]; reduced sarcopenic process and physical frailty in mice [129].…”

Section: Lactobacillusmentioning

confidence: 99%

The Many Ages of Microbiome–Gut–Brain Axis

et al. 2022

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Frailty during aging is an increasing problem associated with locomotor and cognitive decline, implicated in poor quality of life and adverse health consequences. Considering the microbiome–gut–brain axis, we investigated, in a longitudinal study, whether and how physiological aging affects gut microbiome composition in wild-type male mice, and if and how cognitive frailty is related to gut microbiome composition. To assess these points, we monitored mice during aging at five selected experimental time points, from adulthood to senescence. At all selected experimental times, we monitored cognitive performance using novel object recognition and emergence tests and measured the corresponding Cognitive Frailty Index. Parallelly, murine fecal samples were collected and analyzed to determine the respective alpha and beta diversities, as well as the relative abundance of different bacterial taxa. We demonstrated that physiological aging significantly affected the overall gut microbiome composition, as well as the relative abundance of specific bacterial taxa, including Deferribacterota, Akkermansia, Muribaculaceae, Alistipes, and Clostridia VadinBB60. We also revealed that 218 amplicon sequence variants were significantly associated to the Cognitive Frailty Index. We speculated that some of them may guide the microbiome toward maladaptive and dysbiotic conditions, while others may compensate with changes toward adaptive and eubiotic conditions.

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“…The benefits of probiotics have also been investigated using rodent models of aging [SAMP-8 ( 30 – 32 ) and D-galactose ( 33 )] and animal models of cachexia ( 34 ). However, researchers have rarely used healthy older rodents ( 35 ) and have never used “frail” rodents, such as older, food-restricted rats.…”

Section: Introductionmentioning

confidence: 99%

Lacticaseibacillus casei CNCM I-5663 supplementation maintained muscle mass in a model of frail rodents

et al. 2022

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The aim of this study was to identify a probiotic-based strategy for maintaining muscle anabolism in the elderly. In previous research, we found that individuals experiencing short bowel syndrome (SBS) after an intestinal resection displayed beneficial metabolic adjustments that were mediated by their gut microbes. Thus, these bacteria could potentially be used to elicit similar positive effects in elderly people, who often have low food intake and thus develop sarcopenia. Gut bacterial strains from an SBS patient were evaluated for their ability to (1) maintain Caenorhabditis elegans survival and muscle structure and (2) promote protein anabolism in a model of frail rodents (18-month-old rats on a food-restricted diet: 75% of ad libitum consumption). We screened a first set of bacteria in C. elegans and selected two Lacticaseibacillus casei strains (62 and 63) for further testing in the rat model. We had four experimental groups: control rats on an ad libitum diet (AL); non-supplemented rats on the food-restricted diet (R); and two sets of food-restricted rats that received a daily supplement of one of the strains (∼109 CFU; R+62 and R+63). We measured lean mass, protein metabolism, insulin resistance, cecal short-chain fatty acids (SCFAs), and SCFA receptor expression in the gut. Food restriction led to decreased muscle mass [−10% vs. AL (p < 0.05)]. Supplementation with strain 63 tempered this effect [−2% vs. AL (p > 0.1)]. The mechanism appeared to be the stimulation of the insulin-sensitive p-S6/S6 and p-eIF2α/eIF2α ratios, which were similar in the R+63 and AL groups (p > 0.1) but lower in the R group (p < 0.05). We hypothesize that greater SCFA receptor sensitivity in the R+63 group promoted gut-muscle cross talk [GPR41: +40% and GPR43: +47% vs. R (p < 0.05)]. Hence, strain 63 could be used in association with other nutritional strategies and exercise regimes to limit sarcopenia in frail elderly people.

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Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice

Cited by 37 publications

References 62 publications

Effects of L. plantarum HY7715 on the Gut Microbial Community and Riboflavin Production in a Three-Stage Semi-Continuous Simulated Gut System

Effects of L. plantarum HY7715 on the Gut Microbial Community and Riboflavin Production in a Three-Stage Semi-Continuous Simulated Gut System

The Many Ages of Microbiome–Gut–Brain Axis

Lacticaseibacillus casei CNCM I-5663 supplementation maintained muscle mass in a model of frail rodents

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