Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation

Kim, Han Geun; Lee, Seung Yeon; Kim, Na Ra; Lee, Hea Young; Ko, Mi Yeon; Jung, Bong Jun; Kim, Chul Min; Lee, Jung Min; Park, Jong Hwan; Han, Seung Hyun; Chung, Dae Kyun

doi:10.1016/j.molimm.2010.07.011

Cited by 78 publications

(61 citation statements)

References 67 publications

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“…In this study, LTAs purified from the L. plantarum K8 strain induced cross-tolerance and inhibited excessive inflammatory responses induced by the pathogenic components (Kim et al 2011).…”

Section: Bacterial Cell Wall Componentsmentioning

confidence: 76%

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

2011

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The probiotic approach represents a potentially effective and mild alternative strategy for the prevention and treatment of either inflammatory or allergic diseases. Several studies have shown that different bacterial strains can exert their probiotic abilities by influencing the host's immune system, thereby modulating immune responses. However, the emerging concern regarding safety problems arising from the extensive use of live microbial cells is enhancing the interest in non-viable microorganisms or microbial cell extracts, as they could eliminate shelf-life problems and reduce the risks of microbial translocation and infection. The purpose of this review is to provide an overview of the scientific literature concerning studies in which dead microbial cells or crude microbial cell fractions have been used as health-promoting agents. Particular attention will be given to the modulation of host immune responses. Possible mechanisms determining the effect on the immune system will also be discussed. Finally, in the light of the FAO/WHO definition of probiotics, indicating that the word 'probiotic' should be restricted to products that contain live microorganisms, and considering the scientific evidence indicating that inactivated microbes can positively affect human health, we propose the new term 'paraprobiotic' to indicate the use of inactivated microbial cells or cell fractions to confer a health benefit to the consumer.

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“…In this study, LTAs purified from the L. plantarum K8 strain induced cross-tolerance and inhibited excessive inflammatory responses induced by the pathogenic components (Kim et al 2011).…”

Section: Bacterial Cell Wall Componentsmentioning

confidence: 76%

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

2011

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“…Compared to LTA from S. aureus and Bacillus subtilis, LTA from L. plantarum KCTC10887BP only scarcely induced NO in macrophages, showed a weaker activation of TLR2/CD14, and lower induction of TNF in macrophages [27]. LTA from L. plantarum KCTC10887BP even acted as an antagonist of S. aureus LTA-induced TNF production in monocytic cells in a TLR2/ CD14-dependent manner [28], of LPS-induced TNF production in monocytic cells and endotoxin shock in mice [29] and of Shigella flexneri peptidoglycan-induced inflammation in monocytic cells [30]. Recently, multi-spectrometric analyses of this L. plantarum LTA were compared with those of S. aureus LTA [31].…”

Section: Opinionmentioning

confidence: 99%

Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference

Lebeer

Claes

Vanderleyden

2012

Trends in Microbiology

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“…TLR2, in particular, inhibited diet-and pathogen-associated atherosclerosis in ApoE knockout mice (Madan and Amar, 2008). In our previous study, we showed that pLTA induces "tolerance" against LPS via TLR2 signaling (Kim et al, 2008;2011). pLTA-mediated tolerance alleviates LPS-induced inflammation, and TLR2-TLR4 crosstalk plays an important role in this process.…”

Section: A B C D Ementioning

confidence: 95%

Lipoteichoic Acid Isolated from Lactobacillus plantarum Suppresses LPS-Mediated Atherosclerotic Plaque Inflammation

Kim

Jung

et al. 2013

Molecules and Cells

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Chronic inflammation plays an important role in atherogenesis. Experimental studies have demonstrated the accumulation of monocytes/macrophages in atherosclerotic plaques caused by inflammation. Here, we report the inhibitory effects of lipoteichoic acid (LTA) from Lactobacillus plantarum (pLTA) on atherosclerotic inflammation. pLTA inhibited the production of proinflammatory cytokines and nitric oxide in lipopolysaccharide (LPS)-stimulated cells and alleviated THP-1 cell adhesion to HUVEC by down-regulation of adhesion molecules such as intracellular adhesion molecule-1 (ICAM-I), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. The inhibitory effect of pLTA was mediated by inhibition of NF-κB and activation of MAP kinases. Inhibition of monocyte/macrophage infiltration to the arterial lumen was shown in pLTAinjected ApoE -/-mice, which was concurrent with inhibition of MMP-9 and preservation of CD31 production. The antiinflammatory effect mediated by pLTA decreased expression of atherosclerotic markers such as COX-2, Bax, and HSP27 and also cell surface receptors such as TLR4 and CCR7. Together, these results underscore the role of pLTA in suppressing atherosclerotic plaque inflammation and will help in identifying targets with therapeutic potential against pathogen-mediated atherogenesis.

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Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation

Cited by 78 publications

References 67 publications

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference

Lipoteichoic Acid Isolated from Lactobacillus plantarum Suppresses LPS-Mediated Atherosclerotic Plaque Inflammation

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