Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory Effects on the Biofilm Formation of Dental Pathogenic Bacteria

Lee, Dong‐Wook; Im, Jino; Park, Dong Hyun; Jeong, Sungho; Park, Miri; Yoon, Seokmin; Park, Jaewoong; Han, Seung Hyun

doi:10.3389/fmicb.2021.758161

Cited by 11 publications

(5 citation statements)

References 44 publications

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“…Lactobacilli adhesins can cause significant adhesion to the vaginal wall. The strong adhesion of lactobacilli to the vaginal epithelium results in exclusion and rejection of harmful pathogens ( Lee et al., 2021 ; Kawahara et al., 2022 ). Lactobacilli also exhibit immunomodulatory effects by increasing monocytes and macrophages which play a crucial role in the innate immune response via activation of Toll-like receptors (TLR) and the generation of cytokines ( Mitchell et al., 2021 ).…”

Section: Lactobacilli In the Vagina And Their Crucial Functionmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the proliferation of other pathogenic microorganisms, and promote the maintenance of a eubiotic vaginal microbiome. However, a vaginal flora with a reduced proportion or abundance of lactobacilli is associated with various vaginal infections that have been linked to serious health consequences such as infertility, preterm birth, pelvic inflammatory disease, premature rupture of membranes, and miscarriage. Due to their “Generally Recognized as Safe” classification and critical role in vaginal health, probiotic lactobacilli have been widely used as an alternative or adjunct to traditional antibiotic therapy for the treatment of vaginal infections and restoration of the vaginal microbiome. This review focuses on the significant role of probiotic lactobacilli in the vaginal microenvironment and discusses the use of probiotic lactobacilli in the treatment of female vaginal infections in vitro and in vivo.

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Section: Lactobacilli In the Vagina And Their Crucial Functionmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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“…The LTA structure varies among different bacterial species [ 51 ]. LTAs from various L. plantarum strains also have different effects on anti-biofilm for dental pathogenic bacteria [ 52 ]. Our previous study observed that GMNL-653 uniquely expresses six genes involved in cell wall/membrane/envelop biogenesis compared with the other two L. paracasei strains (GMNL-855 and BCRC 16100).…”

Section: Discussionmentioning

confidence: 99%

Heat-killed Lacticaseibacillus paracasei GMNL-653 ameliorates human scalp health by regulating scalp microbiome

et al. 2023

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Background The equilibrium of the scalp microbiome is important for maintaining healthy scalp conditions, including sebum secretion, dandruff, and hair growth. Many different strategies to improve scalp health have been reported; however, the effect of postbiotics, such as heat-killed probiotics, on scalp health remains unclear. We examined the beneficial effects of heat-killed probiotics consisting of Lacticaseibacillus paracasei, GMNL-653, on scalp health. Results Heat-killed GMNL-653 could co-aggregate with scalp commensal fungi, Malassezia furfur, in vitro, and the GMNL-653-derived lipoteichoic acid inhibited the biofilm formation of M. furfur on Hs68 fibroblast cells. The mRNA of hair follicle growth factors, including insulin-like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor, IGF-1, and keratinocyte growth factor was up-regulated in skin-related human cell lines Hs68 and HaCaT after treatment with heat-killed GMNL-653. For clinical observations, we recruited 22 volunteer participants to use the shampoo containing the heat-killed GMNL-653 for 5 months and subsequently measured their scalp conditions, including sebum secretion, dandruff formation, and hair growth. We applied polymerase chain reaction (PCR) to detect the scalp microbiota of M. restricta, M. globosa, Cutibacterium acnes, and Staphylococcus epidermidis. A decrease in dandruff and oil secretion and an increase in hair growth in the human scalp were observed after the use of heat-killed GMNL-653-containing shampoo. The increased abundance of M. globosa and the decreased abundance of M. restricta and C. acnes were also observed. We further found that accumulated L. paracasei abundance was positively correlated with M. globosa abundance and negatively correlated with C. acnes abundance. S. epidermidis and C. acnes abundance was negatively correlated with M. globosa abundance and positively correlated with M. restricta. Meanwhile, M. globosa and M. restricta abundances were negatively associated with each other. C. acnes and S. epidermidis abundances were statistically positively correlated with sebum secretion and dandruff, respectively, in our shampoo clinical trial. Conclusion Our study provides a new strategy for human scalp health care using the heat-killed probiotics GMNL-653-containing shampoo. The mechanism may be correlated with the microbiota shift.

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“…have shown to inhibit the growth of Streptococcus sp. ( Wasfi et al, 2018 ; Lee et al, 2021 ; Kim et al, 2022 ). Lactobacillus sp.…”

Section: Discussionmentioning

confidence: 99%

Gut and lung microbiome profiles in pregnant mice

et al. 2022

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In recent years, microbiome research has expanded from the gastrointestinal tract to other host sites previously thought to be abacterial such as the lungs. Yet, the effects of pregnancy in the lung and gut microbiome remains unclear. Here we examined the changes in the gut and lung microbiome in mice at 14 days of gestation. Lung tissue and stool samples were collected from pregnant and non-pregnant female BALB/c mice, DNA was isolated, amplified, and bacterial specific V4 16S rRNA gene was sequenced. Using an in-house bioinformatic pipeline we assessed the microbial composition of each organ using stool and lung tissue samples. The stool data showed that Lachnospiraceae and Lactobacillaceae were more abundant in the pregnant mice. Likewise, Lactobacillaceae were dominant in the lungs of pregnant mice. However, Streptococcaceae were dominant in the lungs of non-pregnant mice with a low microbial abundance in the pregnant mice. A permutation test showed that pregnancy significantly contributes to the variance in both the lung and stool microbiome. At the same time, we estimate that 49% of the total detected operational taxonomic units were shared between the stool and lung data. After removing common stool-associated bacteria from the lung dataset, no microbial differential abundance was detected between the pregnant and non-pregnant lung microbial community. Thus, pregnancy contributes to variance to the lung and stool microbiome but not in the unique lung microbiota.

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Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory Effects on the Biofilm Formation of Dental Pathogenic Bacteria

Cited by 11 publications

References 44 publications

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Heat-killed Lacticaseibacillus paracasei GMNL-653 ameliorates human scalp health by regulating scalp microbiome

Gut and lung microbiome profiles in pregnant mice

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