Lactobacillus plantarum Prevents the Upregulation of Adhesion Molecule Expression in an Experimental Colitis Model

Chu, Zhaoxin; Chen, Hongqi; Ma, Yanlei; Zhou, Yukun; Zhang, Ming; Zhang, Peng; Qin, Huanlong

doi:10.1007/s10620-009-1063-2

Cited by 22 publications

(13 citation statements)

References 42 publications

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“…It is noted that 4-wk LP treatment did not affect the expression of proinflammatory cytokines (e.g., TNF-␣ and IFN-␥) in our previous study in which Ϫ/Ϫ mice were treated at 4-wk old when the colonic inflammation is just developing (10). However, in the present study, IL-10 Ϫ/Ϫ mice were treated at 8 wk old when the intestinal inflammation has already been established, as confirmed by Madsen et al (24,26).…”

Section: Discussionmentioning

confidence: 69%

Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice

Chen¹,

Yang²,

Zhang

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 69%

Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice

Chen¹,

Yang²,

Zhang

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…This may indicate that the probiotic diminishes cell-cell adhesion by blunting adhesion molecule expression and/or inhibiting chemokine production. Findings outlined in previous reports by others indicate that Lactobacillus plantarum 36 and Lactobacillus casei 37 , both of which are found in VSL#3, inhibit the expression of ICAM-1 and MAdCAM-1 in a mouse model of experimental colitis. Chemokines (e.g., CXCL-1, CCL-3 and CCL-11) that mediate leukocyte recruitment are produced at an accelerated rate in experimental colitis 14 , and mice deficient in these chemokines or their receptors are protected against DSS-induced inflammation injury and tissue injury 14, 35, 38 .…”

Section: Discussionmentioning

confidence: 70%

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

Souza

Senchenkova

Russell

et al. 2015

Inflammatory Bowel Diseases

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Several studies in IBD patients and in animal models of IBD have revealed a protective effect of probiotics in reducing clinical symptoms of disease and in blunting the gut inflammation that accompanies this condition. However, the mechanism underlying the therapeutic effect of probiotics is currently unknown. Furthermore, the ability of probiotics to influence the enhanced thrombus development that accompanies IBD has not been studied. This study addresses whether the enhanced extra-intestinal thrombosis (induced by light/dye injury) associated with experimental colitis is altered by oral treatment with the probiotic preparation VSL#3 or by the absence of microbiota. Colitis was induced by DSS 3% in Swiss Webster mice, germ free mice, C57BL/6 WT or Myd88−/− mice. In some experiments, mice received VSL#3 for 8 days before and during DSS feeding. Swiss Webster mice were also subjected to a chronic model of DSS colitis and the effect of VSL#3 was evaluated. VSL#3 treatment significantly attenuated the accelerated thrombus formation observed in both acute and chronic models of colitis. VSL#3-treated mice also exhibited attenuated inflammatory response and injury in the colon. The protective effects of VSL#3 on colitis-associated thrombogenesis and inflammation were not evident in MyD88-deficient mice. Our results suggest that improved control of the enteric microflora in IBD may afford protection against the hypercoagulable, prothrombotic state that follows this condition.

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“…Other studies have evidenced the capacity of probiotics to modulate homing markers. Lactobacillus plantarum and its excreted peptide STp have shown stimulation of skin-homing markers in vitro , such as cutaneous lymphocyte-associated antigen (CLA), and a decrease in MadCAM-1 and α4β7 integrin expression in colonic mucosa in a mouse model of colitis [57–59]. These effects can be useful to attenuate the intestinal inflammation in IBD.…”

Section: Discussionmentioning

confidence: 99%

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

et al. 2016

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This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immune maturation. However, it increased the proportion of cells bearing TLR4 in the MLN and IEL, and enhanced the percentage of the integrin αEβ7+ and CD62L+ cells in the MLN and that of the integrin αEβ7+ cells in the IEL, suggesting an enhancement of the homing process of naïve T lymphocytes to the MLN, and the retention of activated lymphocytes in the intraepithelial compartment. Interestingly, B. breve M-16V enhanced the intestinal IgA synthesis. In conclusion, supplementation with the probiotic strain B. breve M-16V during suckling improves the development of mucosal immunity in early life.

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Lactobacillus plantarum Prevents the Upregulation of Adhesion Molecule Expression in an Experimental Colitis Model

Abstract: L. plantarum interfered with the upregulation of adhesion molecules observed in IL-10 knockout mice compared to wild-type mice, attenuating the symptoms of colitis.

Cited by 22 publications

References 42 publications

Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice

Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

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