Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats

Bejar, Wacim; Hamden, Khaled; Salah, Riadh Ben; Chouayekh, Hichem

doi:10.1016/j.anaerobe.2013.08.006

Cited by 48 publications

(44 citation statements)

References 34 publications

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“…is a genus of common probiotics that have been widely used in food and pharmaceutical industry [39,40,41]. Besides, many strains of Lactobacillus have been successfully applied to attenuate obesity [42,43,44], diabetes [45,46,47], diarrhea [48,49,50], and many other diseases [51,52,53] which are associated with gut dysbiosis. In this regard, since dietary KS significantly promoted the growth of Lactobacillus spp., further studies are therefore warranted to elucidate whether KS as a new dietary prebiotic could be used to alleviate the aforementioned diseases.…”

Section: Resultsmentioning

confidence: 99%

Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.

Shang

Zhang

et al. 2016

Marine Drugs

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Keratan sulfate (KS) represents an important family of glycosaminoglycans that are critical in diverse physiological processes. Recently, accumulating evidence has provided a wealth of information on the bioactivity of KS, which established it as an attractive candidate for drug development. However, although KS has been widely explored, less attention has been given to its effect on gut microbiota. Therefore, given that gut microbiota plays a pivotal role in health homeostasis and disease pathogenesis, we investigated here in detail the effect of KS on gut microbiota by high-throughput sequencing. As revealed by heatmap and principal component analysis, the mice gut microbiota was readily altered at different taxonomic levels by intake of low (8 mg/kg) and high dosage (40 mg/kg) of KS. Interestingly, KS exerted a differing effect on male and female microbiota. Specifically, KS induced a much more drastic increase in the abundance of Lactobacillus spp. in female (sixteen-fold) versus male mice (two-fold). In addition, combined with alterations in gut microbiota, KS also significantly reduced body weight while maintaining normal gut homeostasis. Altogether, we first demonstrated a sex-dependent effect of KS on gut microbiota and highlighted that it may be used as a novel prebiotic for disease management.

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Section: Resultsmentioning

confidence: 99%

Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.

Shang

Zhang

et al. 2016

Marine Drugs

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“…Ultimately, 33 articles were included in the final analysis, consisting of five human and 28 animal reports . Information on human and animal studies in relation to methodological quality, characteristics of participants, interventions and outcome measures are summarized in Tables and .…”

Section: Resultsmentioning

confidence: 99%

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Razmpoosh

Javadi

Ejtahed

et al. 2015

Diabetes Metabolism Res

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Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti-diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved 1120 reports. After screening titles and abstracts, 72 full-text articles were reviewed for eligibility. Ultimately, 33 articles met our inclusion criteria consisting of five human and twenty eight animal reports. Lactobacillus strains were, in particular, used in all studies with or without other strains. We found that probiotics have beneficial effects on glycemic controls, as all human studies showed significant reductions in at least one of the primary outcome endpoints which were the levels of fasting plasma glucose, postprandial blood glucose, glycated haemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all the animal reports, except for two, documented significant changes in these parameters. Regarding secondary outcome measures, that is, lipid profiles, pro-inflammatory and anti-oxidant factors, only one human and one animal study failed to show any significant changes in any of these parameters. This systematic review generally demonstrated beneficial effects of the probiotic administration, especially Lactobacillus sub-strains, on the management of diabetes-related blood parameters, although, more evidence, especially from human trials, is needed to confirm these effects and also to conduct a meta-analysis. Copyright © 2015 John Wiley & Sons, Ltd.

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“…The disability of the kidney in the diabetic rats to filter properly leads to the accumulation of waste and toxic substances, such as uric acid, creatinine, and urea nitrogen in the blood. 36 STZ-induced diabetic rats showed an increase of uric acid, creatinine, and urea nitrogen, and the supplementation with soymilk fermented with L. rhamnosus CRL981 did not have any effect in diabetic rats. 16 Morphologically, the findings of this study revealed the efficiency of NCU and FCJ in protecting the kidney of diabetic rats, which was evidenced by the lower rates observed for kidney dysfunction indices (Table 4 and Figure 2).…”

Section: ■ Discussionmentioning

confidence: 95%

Carrot Juice Fermented with Lactobacillus plantarum NCU116 Ameliorates Type 2 Diabetes in Rats

Ding

Nie

et al. 2014

J. Agric. Food Chem.

118

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The effect of carrot juice fermented with Lactobacillus plantarum NCU116 on high-fat and low-dose streptozotocin (STZ)-induced type 2 diabetes in rats was studied. Rats were randomly divided into five groups: non-diabetes mellitus (NDM), untreated diabetes mellitus (DM), DM plus L. plantarum NCU116 (NCU), DM plus fermented carrot juice with L. plantarum NCU116 (FCJ), and DM plus non-fermented carrot juice (NFCJ). Treatments of NCU and FCJ for 5 weeks were found to favorably regulate blood glucose, hormones, and lipid metabolism in the diabetic rats, accompanied by an increase in short-chain fatty acid (SCFA) in the colon. In addition, NCU and FCJ had restored the antioxidant capacity and morphology of the pancreas and kidney and upregulated mRNA of low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (CYP7A1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ). These results have for the first time demonstrated that L. plantarum NCU116 and the fermented carrot juice had the potential ability to ameliorate type 2 diabetes in rats.

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Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats

Cited by 48 publications

References 34 publications

Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.

Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Carrot Juice Fermented with Lactobacillus plantarum NCU116 Ameliorates Type 2 Diabetes in Rats

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