Lactobacillus reuteri associated with scaling and root planing in the treatment of periodontitis in rats submitted to chemotherapy

Comparative effects of different phenothiazine photosensitizers on experimental periodontitis treatment

“…On the first day of the experimental protocol, the rats were placed on an adapted surgical table, where a cotton ligature (cotton thread # 24, Coats Corrente®, SP, Brazil) was installed around the first left lower molar of each animal the in order to induce EP [30]. The ligature was stabilized in a sub-gingival position with a surgical knot [30].…”

“…For scaling and root planing the cotton ligatures were removed and antisepsis of the oral cavity was performed on the buccal and lingual surfaces, consisting of 10 tensiomesial traction movements and, in the interproximal and furcation areas, 10 cervical-occlusal traction movements, using mini-five 1-2 hand curettes (Hu-Friedy Co. Inc., Chicago, IL, USA) [7,30].…”

The effects of Lactobacillus reuteri on the inflammation and periodontal tissue repair in rats: A pilot study

“…Each systemic PRO application consisted of 0.16 ml (1 × 10 8 CFU of L. reuteri ), which was administered directly into the gastric tube of the animal with an irrigation cannula. The EP and SRP + SS group similarly received 0.16 ml of SS ( Miessi et al, 2020 ).…”

“…Animal studies have evaluated the local and systemic effects of PROs on experimental periodontitis ( Garcia et al, 2016 , Messora et al, 2016 , Oliveira et al, 2017 , Ricoldi et al, 2017 , Miessi et al, 2020 ). These studies have obtained favourable results in bone loss (BL) reduction, recolonization of areas with periodontitis induced by periodontopathogens, and a decrease in the quantity of anaerobic bacteria and pro-inflammatory cytokines ( Garcia et al, 2016 , Messora et al, 2016 , Oliveira et al, 2017 , Ricoldi et al, 2017 , Miessi et al, 2020 ). In addition, the use of PROs can improve tissue inflammation and SRP effectiveness.…”

“…In addition, the use of PROs can improve tissue inflammation and SRP effectiveness. Among PROs belonging to the Lactobacillus species, Lactobacillus reuteri ( L. reuteri ) is important for its capacity to allow the secretion of bacteriocins, reuterine and reutericyclin ( Miessi et al, 2020 ). Furthermore, the anti-inflammatory effects and inhibitory effects on cytokine secretion could be the reason for its beneficial effects on periodontal diseases ( Alok et al, 2017 ).…”