Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

The Role of Microbiota and Immunobiotics in Granulopoiesis of Immunocompromised Hosts

“…These histological alterations may be responsible for the damage of the hematopoietic niches, which may influence the crosstalk between hematopoietic cells and the growth factors that regulate the granulopoiesis. In line with Borelli et al ( 34 ), a reduction of GMPs was observed in BM of malnourished mice that could explain the reduction of myeloid cells of BM and blood ( 7 , 35 ). Thus, nutritional deficiencies affect hematopoiesis, leading to an immunocompromised condition ( 35 ).…”

The probiotic activity of Lactobacillus murinus against food allergy

“…Our results on T cell cytokines and IgE clearly demonstrated that L. murinus polarized the Th1/Th2 immunobalance towards Th1 direction in allergic mice. Probiotic LAB has been reported to induce immunomodulatory effects via various mechanisms depending on different probiotic LAB studied (Chiu, Tsai, Lin, Chotirosvakin, & Lin, 2014;Faghfoori, Gargari, Gharamaleki, Bagherpour, & Khosroushahi, 2015;Herrera, Salva, Villena, Barbieri, & Alvarez, 2013;Juarez, Villena, Salva, de Valdez, & Rodriguez, 2013;Kim et al, 2015;Mian et al, 2016). In this study, the duodenal expression of IL-10 was attenuated in allergic mice treated with L. murinus.…”

Non-viable immunobiotic Lactobacillus rhamnosus CRL1505 and its peptidoglycan improve systemic and respiratory innate immune response during recovery of immunocompromised-malnourished mice

“…Our results demonstrated that LAB strains that are able to beneficially modulate the immune system (immunobiotics) represent an attractive safe way to regulate and enhance immune function in immunocompromised malnourished hosts [16,17]. In this regard, we recently demonstrated that repletion of malnourished mice with treatments including nasally administered viable L. rhamnosus CRL1505 is able to significantly accelerate the recovery of granulopoiesis and improve innate immunity [18]. We previously observed that malnutrition significantly impaired the production of TNF-α, IL-1β and IL-6 and the recruitment of neutrophils into the respiratory tract after pneumococcal challenge.…”