Lactobacillus sakei OK67 ameliorates high-fat diet–induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression

Lim, Seungyup; Jeong, Jin-Ju; Woo, Kyung Hee; Han, Myung Joo; Kim, Dong-Hyun

doi:10.1016/j.nutres.2015.12.001

Cited by 148 publications

(108 citation statements)

References 39 publications

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“…In our study, glucose and insulin levels in blood serum, and HOMA insulin resistance index [16], as well as IL-1β and IL-12Br40 production were also increased in rats with MSG-induced obesity comparing with intact rats. These parameters of carbohydrate metabolism indicate the development of insulin resistance and type II diabetes in rats with MSGinduced obesity, which is connected with lowgrade inflammation development.…”

Section: Resultssupporting

confidence: 61%

“…Therefore, as we recently established, glucose and insulin levels in blood serum and HOMA insulin resistance index in the MSGgroup dropped under the influence of probiotic bacteria, but the insulin level in blood serum and HOMA insulin resistance index did not restore to those levels in intact animals [16]. Under the influence of probiotic strains and probiotic composition total cholesterol, very low-density lipoprotein and high-density lipoprotein levels decreased, and the low-density lipoprotein level increased comparing with those in the MSG-group.…”

Section: Resultsmentioning

confidence: 60%

“…Hence We had previously shown [16] such biomarkers of MSG-induced visceral obesity in newborn rats: increased body mass index, Lee index, mass of the visceral adipose tissue and decreased body length; abnormalities in the lipid and carbohydrate metabolism as well as decreased adiponectin level in blood serum and increased leptin level in adipose tissue.In this study, we established that neonatal administration of MSG to newborn rats lead to increased pro-inflammatory cytokines production such as IL-1β and IL-12Br40. In contrast, the production of anti-inflammatory cytokines such as IL-4, IL-10, and TGF-β in rats with MSG-induced obesity decreased.…”

Section: Resultsmentioning

confidence: 97%

“…The probiotic composition more effectively prevents monosodium glutamate-induced obesity in rats [16].…”

Section: Resultsmentioning

confidence: 98%

“…These results suggest the potential using of probiotics in order to alleviate the occurrence of metabolic diseases by less radical approach comparing with drugs or hormone therapy. We showed that preliminary selected and characterized probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB and their various compositions have high ability to balance immune response to infectious diseases [15] and are able to effectively prevent MSG-obesity in rats [16].…”

Section: Introductionmentioning

confidence: 99%

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Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Falalyeyeva¹,

Leschenko²,

Берегова³

et al. 2017

Fiziol Zh

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The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro-and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing of the IL-4, IL-10 and tumor growth factor (TGF)-β levels in the blood serum. After administration of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition to obese rats the level of the IL-1β in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically significant difference comparing with intact rats. The level of the IL-12B p40 in blood serum was decreased under influence of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition (18.9 %, p < 0.05) and B. animalis VKL (10.5 %, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition the levels of the IL-4, IL-

show abstract

Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 97%

“…The probiotic composition more effectively prevents monosodium glutamate-induced obesity in rats [16].…”

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Falalyeyeva¹,

Leschenko²,

Берегова³

et al. 2017

Fiziol Zh

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Advances in the role and mechanism of lactic acid bacteria in treating obesity

Shen

Zhang

Yang

et al. 2022

Food Bioengineering

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Obesity and its related complications have become increasingly serious social problems that threaten people's lives. Lactic acid bacteria (LAB) have shown an effective influence on preventing obesity in animal experiments and human clinical trials, but its exact mechanism remains unclear. In this review, LAB and several of its metabolites are taken as the point of penetration. It is aimed to summarize the relationship between obesity and gut microbiota, the efficacy of LAB, and its potential mechanisms of preventing obesity and lipid metabolism. LAB intervention can regulate gut microbiota and improve intestinal permeability which is damaged by a high-fat diet or lipopolysaccharide. Besides this, some metabolites produced by LAB can be involved in regulating host lipid metabolism-related pathways. Short-chain fatty acids, linoleic acid, and gammaaminobutyric acid, taken as representatives here, can participate in the regulation through AMP-activated protein kinase or peroxisome proliferator-activated receptor pathway and bowel-brain axis. Therefore, the ingestion of LAB may become a potential adjunctive treatment for obesity in future.

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An overview of microbiome based strategies on anti‐obesity

Chang

Ruan

Kao

2019

The Kaohsiung J of Med Scie

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With the significant global obesity epidemic and emerging strong scientific evidence that connected gut microbiota to obesity, intervening obesity by targeting gut microbiota has become a trendy strategy. Particularly the application of probiotics has become remarkably popular because of their expected association with gut microbiota modulation. Although there are many literatures on the effects of probiotics in obese animal models, most of them reported the effects of probiotic bacteria on metabolic indications with limited information on anti‐obesity itself. Besides, some probiotics have been shown to reduce certain metabolic symptoms but they failed to achieve weight loss. This report reviewed the current literatures on the anti‐obesity effects of next‐generation probiotics in various animal obesity models and discussed the beneficial potential of fecal microbiota transplantation in treating obesity in humans. The purpose of this article is to help guide further research improve the probiotic bacteria experiments in more precise animal obesity models by standardizing the anti‐obesogenesis, obesity control, and treatment assays and hopefully the evidence‐based investigations on harnessing gut microbiota through next‐generation probiotics or fecal microbiota transplantation will develop new interventions to promote and achieve anti‐obesity.

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Lactobacillus sakei OK67 ameliorates high-fat diet–induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression

Cited by 148 publications

References 39 publications

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Advances in the role and mechanism of lactic acid bacteria in treating obesity

An overview of microbiome based strategies on anti‐obesity

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