Lactobacillus salivarius WB21–containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial—reply to letter

Suzuki, Nao; Yoneda, Masahiro; Tanabe, Kazunari; Fujimoto, Aya; Iha, Kosaku; Seno, Kei; Yamada, Kazuhiko; Iwamoto, Tomoyuki; Masuo, Yosuke; Hirofuji, Takao

doi:10.1016/j.oooo.2014.06.014

Cited by 10 publications

(3 citation statements)

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“…shown to reduce the level of volatile sulfur compounds compared with controls. 80 Lactobacillus-based probiotics have also been reported to reduce the level of volatile sulfur compounds, and thus the organoleptic scores, in subjects with malodor, 81,82 although it was interesting that 1 study investigating the effect of incorporation of L. reuteri strains in chewing gum found a significant effect on organoleptic assessments, but not on the levels of volatile sulfur compounds, leading the authors to conclude that substances other than volatile sulfur compounds must contribute to malodor. 83 There is clearly potential for the use of probiotics for the prevention, and possible treatment, of oral disease by reversing dysbiosis.…”

Section: Prob I Oti C S and Re S Ilien Cementioning

confidence: 99%

Resilience of the oral microbiome

Wade

2021

Periodontology 2000

112

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The composition of the oral microbiome has been reviewed previously. 5 Representatives of the Bacteria, Archaea, fungi, protozoa and viruses are present. Recent studies have revealed major new branches of the Bacteria and Archaea. The Candidate Phyla Radiation group within the domain Bacteria may make up to half of bacterial life on earth and members of this group appear to be ubiquitous. 6,7 Interestingly, the organisms within this group studied thus far are small in size, typically passing through filters with a poresize diameter of 0.2 µm, and have small genomes which lack some genes encoding essential functions. 8 This makes them dependent on other bacteria for growth, either growing closely together in an epibiotic way or demonstrating frank parasitism by invading the cells of other bacteria. 9 Three Candidate Phyla Radiation candidate phyla are found in the mouth: Candidatus Saccharibacteria (originally described as Candidate Division TM7), Candidatus Absconditabacteria (SR1), and Candidatus Gracilibacteria (GN02).Representatives of Saccharibacteria have been cultivated in association with Actinomyces species. 9,10 An analogous group, the DPANN This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Prob I Oti C S and Re S Ilien Cementioning

confidence: 99%

Resilience of the oral microbiome

Wade

2021

Periodontology 2000

112

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“…Lactobacillus salivarius WB21 containing tablets have been shown to reduce halitosis (Iwamoto et al 2010, Suzuki et al 2014. Two recent reviews have identified that probiotic therapy also can be used to reduce intra-oral halitosis (Anusha et al 2015, Janczarek et al 2016.…”

Section: Mouth Rinsingmentioning

confidence: 99%

The effect of periodontal therapy on intra‐oral halitosis: a case series

Ademovski

Mårtensson

Persson

et al. 2016

J Clinic Periodontology

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Aim The aim of this study was to evaluate the effects of non‐surgical periodontal therapy on intra‐oral halitosis 3 months after therapy. Material and methods Sixty‐eight adults with intra‐oral halitosis were included in a case series. Intra‐oral halitosis was evaluated at baseline, and at 3 months after treatment using the organoleptic scores (OLS), Halimeter®, and a gas chromatograph. Results Significant reductions for OLS (p < 0.01), total sum of volatile sulphur compounds (T‐VSC) (p < 0.01) and methyl mercaptan (MM) (p < 0.05) values were found after treatment. Hydrogen sulphide (H2S) levels were not significantly reduced. The numbers of probing pockets 4 mm, 5 mm and 6 mm were significantly reduced as a result of therapy (p < 0.001). Bleeding on probing (BOP) and plaque indices were also significantly reduced (p < 0.001). For the 34 individuals with successful periodontal treatment (BOP<20% and a ≥50% reduction of total pocket depth) reductions in OLS (p < 0.01) and T‐VSC scores (p < 0.01) were found. Eleven individuals were considered effectively treated for intra‐oral halitosis presenting with a T‐VSC value <160 ppb, a H2S value <112 ppb and a MM value <26 ppb. Conclusion Non‐surgical periodontal therapy resulted in reduction of OLS, MM and T‐VSC values 3 months after therapy. Few individuals were considered as effectively treated for intra‐oral halitosis.

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“…Lactobacillus and Streptococcus are considered beneficial bacteria present in the oral flora of individuals without halitosis [ 21 ]. Oral malodour has been treated with probiotics such as Streptococcus salivarius , L. reuteri , and L. salivarius ; however, the specific process is unknown [ 16 , 13 , 23 ]. This in vitro research was designed to measure how well L. rhamnosus inhibits the growth of bacteria that cause bad breath.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of the Inhibitory Effect of Lactobacillus rhamnosus on Halitosis-Causing Bacteria: An Invitro Microbiological Study

Patil¹,

Shetty²,

Padhye³

2023

Cureus

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Aim: To determine the effectiveness of Lactobacillus rhamnosus in inhibiting halitosis-causing bacteria relative to other possible inhibitors, such as mouthwashes. Materials and Methods: This in vitro study was done using a diffusion test with three groups with 11 samples in each group: group A, Porphyromonas gingivalis ; group B, Tannerella forsythia ; and group C, Prevotella intermedia . At 24, 48, and 72 hours, the inhibitory effect of L. rhamnosus was tested. Results: A statistically significant difference was seen for halo formation in group A, where all 11 samples showed an inhibitory effect after 72 hours. After 48 hours, seven of the 11 samples in group B and nine of the 11 samples in group C showed inhibitory effects. Conclusion: The study found that L. rhamnosus had an inhibitory effect on halitosis-causing bacteria like P. gingivalis after 72 hours, which was statistically significant. The same was true for T. forsythia and P. intermedia after 48 hours. This means that L. rhamnosus has an inhibitory effect on halitosis-causing bacteria like P. gingivalis .

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Lactobacillus salivarius WB21–containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial—reply to letter

Cited by 10 publications

References 0 publications

Resilience of the oral microbiome

Resilience of the oral microbiome

The effect of periodontal therapy on intra‐oral halitosis: a case series

Comparative Evaluation of the Inhibitory Effect of Lactobacillus rhamnosus on Halitosis-Causing Bacteria: An Invitro Microbiological Study

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