Lactoferrin and ovotransferrin contribute toward antioxidative effects of Edible Bird’s Nest against hydrogen peroxide-induced oxidative stress in human SH-SY5Y cells

Hou, Zhiyuan; Imam, Mustapha Umar; Ismail, Maznah; Azmi, Nur Hanisah; Ismail, Norsharina; Ideris, Aini; Mahmud, Rozi

doi:10.1080/09168451.2015.1050989

Cited by 44 publications

(33 citation statements)

References 32 publications

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“…Similarly, the vascular ROS, especially superoxide anion was elevated in aorta of db/db mice and aorta exposed to high glucose and HBN decreased the superoxide production in the high-glucose exposed tissues, indicating HBN protects against endothelial dysfunction by inhibiting ROS production. This is in agreement with previous researches that showed edible bird's nest ameliorated oxidative stress by reducing production of ROS in SH-SY5Y cells and human keratinocytes (Yew et al, 2014;Hou et al, 2015;Lim et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

“…HBN treatment increased SOD-1 protein level against the reduction induced by HG in the HUVECs and in treated db/db aorta. Likewise, previous reports by Hou et al (2015) demonstrated that treatment with edible bird's nest increased SOD activity and mRNA levels of SOD-1 in H 2 O 2induced oxidative stress in SH-SY5Y cells. Similarly, edible bird's nest reduced the production of ROS in human HaCat keratinocytes and SH-SY5Y human neuroblastoma cells (Kim et al, 2012;Yew et al, 2014).…”

Section: Discussionsupporting

confidence: 70%

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Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

et al. 2020

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Increased oxidative stress by hyperglycemia is a major cause of vascular complications in diabetes. Bird's nest, which is made from the saliva of swiftlets has both medicinal and nutritional values dated back to ancient China. However, its role in improving endothelial dysfunction due to diabetes is yet to be elucidated. The present study examined the protective effect and mechanism of action of the aqueous extract of hydrolyzed edible bird nest (HBN) on endothelium in models of diabetes, in vitro and in vivo. Male db/m+ and db/ db mice were orally administered with or without HBN and glibenclamide for 28 days, followed by vascular reactivity studies in mouse aortas. Human umbilical vein endothelial cells (HUVECs) and isolated mouse aorta from C57BL/6J were treated with high glucose (HG), HBN, sialic acid (SA), glibenclamide, and apocynin, respectively. The effects of HBN on reactive oxygen species (ROS) production and nitric oxide (NO) bioavailability were assessed by Western blot, 2′,7′-dichlorofluorescin-diacetate (DCF-DA), and 4-amino-5methylamino-2′,7′ difluorofluorescein (DAF-FM DA) in HUVECs, isolated mouse aorta, and db/db diabetic mice. HBN significantly reversed the endothelial dysfunction in diabetic mice and isolated mouse aorta. HBN normalized ROS overproduction of NOX2 and nitrotyrosine, reversed the reduction of anti-oxidant marker, SOD-1 as well as restored NO bioavailability in both HUVECs challenged with HG and in db/db diabetic mice. Similarly, HG-induced elevation of oxidative stress in HUVECs were reversed by SA, glibenclamide, and apocynin. This attests that HBN restores endothelial function and protects endothelial cells against oxidative damage induced by HG in HUVECs, isolated mouse aorta, and db/ db diabetic mice via modulating ROS mechanism, which subsequently increases NO bioavailability. This result demonstrates the potential role of HBN in preserving endothelial function and management of micro-or macrovascular complications in diabetes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 70%

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

et al. 2020

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“…Results showed that the digested samples displayed potent antioxidant activities that contributed to the reduction in oxidative stress markers. Similarly in another study, EBN displayed protective effect against hydrogen peroxide-induced toxicity in SH-SY5Y cells [9] . Hydrogen peroxide is a chemical which induces oxidative stress in cells.…”

Section: Anti-oxidant Properties Of Ebnmentioning

confidence: 52%

“…The protective effect of EBN suggested that it had the ability to scavenge free radicals and decrease radical oxygen species, thereby lowering the oxidative stress. Hou et al, further suggested that the antioxidant properties of EBN were conferred by its constituents, namely lactoferrin and ovotransferrin [9] .…”

Section: Anti-oxidant Properties Of Ebnmentioning

confidence: 99%

A Mini Review on Medicinal Effects of Edible Bird’s Nest

Chye¹,

Tai²,

Koh³

et al. 2017

LHBS

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Edible bird's nest is a famous and nutritious food which is well-known among Chinese community. It is made from the saliva of swiftlets. It is consumed for various reasons, including as health tonic, complexion enhancer, asthma alleviator and immune system enhancer. It contains both macronutrients and micronutirents such as carbohydrates, glycoproteins, calcium, sodium, magnesium, zinc, manganese, iron and others. To date, a number of studies have reported on the health benefits of EBN consumption. Hence, this review describes the various medicinal values of EBN.

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“…More recent scientific evidence suggests that EBN is both nutritionally and functionally rich [ 16 – 18 ]. Its components include lactoferrin, sialic acid, ovotransferrin, minerals, and amino acids including essential amino acids, such as lysine, tyrosine, and serine [ 16 , 17 , 19 ]. There is some evidence to support its anti-inflammatory, antioxidant, and insulin-sensitizing effects [ 19 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

Edible Bird’s Nest Prevents Menopause‐Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin‐1 Expression

Hou

Imam

et al. 2017

Oxidative Medicine and Cellular Longevity

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Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird's nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. Ovariectomized female Sprague-Dawley rats were fed with normal pellet alone or normal pellet + EBN (6, 3, or 1.5%), compared with estrogen therapy (0.2 mg/kg/day). After 12 weeks of intervention, Morris water maze (four-day trial and one probe trial) was conducted, and serum estrogen levels, toxicity markers (alanine transaminase, alkaline phosphatase, urea, and creatinine), and hippocampal SIRT1 immunohistochemistry were estimated after sacrifice. The results indicated that EBN and estrogen enhanced spatial learning and memory and increased serum estrogen and hippocampal SIRT1 expression. In addition, the EBN groups did not show as much toxicity to the liver as the estrogen group. The data suggested that EBN treatment for 12 weeks could improve cognition and memory in ovariectomized female rats and may be an effective alternative to estrogen therapy for menopause-induced aging-related memory loss.

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Lactoferrin and ovotransferrin contribute toward antioxidative effects of Edible Bird’s Nest against hydrogen peroxide-induced oxidative stress in human SH-SY5Y cells

Cited by 44 publications

References 32 publications

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

A Mini Review on Medicinal Effects of Edible Bird’s Nest

Edible Bird’s Nest Prevents Menopause‐Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin‐1 Expression

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