2018
DOI: 10.1039/c8fo00317c
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Lactoferrin attenuates high-fat diet-induced hepatic steatosis and lipid metabolic dysfunctions by suppressing hepatic lipogenesis and down-regulating inflammation in C57BL/6J mice

Abstract: Lactoferrin was reported to exert modulatory effects on lipid metabolism, but the regulatory mechanisms remain unclear. The present study investigated the beneficial effects of lactoferrin and their underlying mechanisms in high-fat diet-induced obese C57BL/6J mice. Oral administration of lactoferrin at 100 mg per body weight for 15 weeks significantly reduced weight gain, visceral adiposity, and serum glucose, leptin, and lipid levels in high-fat diet-induced obese mice. Hepatic steatosis in the obese mice wa… Show more

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Cited by 32 publications
(30 citation statements)
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“…The former study showed a decrease in body weight, epididymal white adipose, and serum TG level with no effect on liver weight [ 7 ]; however, the latter study found a decrease in liver weight, with no effects on body weight and adiposity [ 8 ]. For Lf, both Sun and Xiong found that long-term administration decreased body weight, fat weight, and serum and hepatic TG in the obese mice maintained on a HFD [ 18 , 19 ]. Similar with our result, the alleviation of hepatic lipid accumulation by Met and Lf treatments was also observed in the H and E and Oil Red O stainings in these animal studies [ 7 , 8 , 12 , 18 ].…”
Section: Discussionmentioning
confidence: 99%
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“…The former study showed a decrease in body weight, epididymal white adipose, and serum TG level with no effect on liver weight [ 7 ]; however, the latter study found a decrease in liver weight, with no effects on body weight and adiposity [ 8 ]. For Lf, both Sun and Xiong found that long-term administration decreased body weight, fat weight, and serum and hepatic TG in the obese mice maintained on a HFD [ 18 , 19 ]. Similar with our result, the alleviation of hepatic lipid accumulation by Met and Lf treatments was also observed in the H and E and Oil Red O stainings in these animal studies [ 7 , 8 , 12 , 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…Meta-analyses demonstrated that Met increased serum adiponectin levels [ 33 ], but had no effect on blood leptin [ 34 ] when treating type 2 diabetes mellitus. On the other hand, Xiong et al found that Lf significantly reduced leptin and monocyte chemotatic protein-1 levels but had no effect on adiponectin [ 19 ].…”
Section: Discussionmentioning
confidence: 99%
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