Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-S-S-PLA-PCL-OH boost delivery of bacosides to the brain

Goyal, Kritika; Konar, Arpita; Kumar, B.S. Hemanth; Koul, Veena

doi:10.1039/c8nr03828g

Cited by 34 publications

(21 citation statements)

References 101 publications

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“…213 More examples of herbal loaded PS are found in Table 1. 208,[214][215][216][217] Cubosome It is a viscous isotropic vesicle that made mainly of unsaturated monoglycerides (monoolein-water) binary system with thermodynamically steric stable bi-continuous cubic liquid crystalline phase (poloxamers) (Figure 15). 218,219 Features such as high internal surface area per unit volume (approximately 400 m 2 /g) and a 3D structure with hydrophilic and hydrophobic domains make them entrap water-soluble and nonsoluble and amphiphilic materials successfully.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

156

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

156

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show abstract

“…Moreover, Goyal et al developed new triblock copolymers based on PEG-PLA-PCL conjugated with Lf to act as a brain delivery vector of bacosides, which are used in Indian Ayurveda for the reversal of amnesia. Induced amnesic mice treated with these nanosystems showed significant memory loss reversal [116]. For selective docetaxel delivery into the brain tissue, Singh et al developed SLN functionalized with Lf.…”

Section: Proteinsmentioning

confidence: 99%

“…The receptor-mediated transport shuttles a range of proteins directly to the brain parenchyma by using the vesicular trafficking of the brain endothelial cells (endocytosis, transcytosis and exocytosis) [190,194]. The conjugation of ligands natively recognized by brain endothelial cells, such as Tf [111,112] and Lf [115][116][117], is a promising alternative for brain drug delivery. For further reading on these and other potential ligands, please refer to the review by Lajoie et al [194].…”

Section: Blood-brain Barriermentioning

confidence: 99%

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

et al. 2020

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Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed to date is the presence of the CNS barriers that restrict the access to the brain. However, adequate brain biodistribution and neuronal cells specific accumulation in the targeted site also represent major hurdles to the attainment of a successful CNS treatment. Over the last few years, nanotechnology has taken a step forward towards the development of therapeutics in neurologic diseases and different approaches have been developed to surpass these obstacles. The versatility of the designed nanocarriers in terms of physical and chemical properties, and the possibility to functionalize them with specific moieties, have resulted in improved neurotargeted delivery profiles. With the concomitant progress in biology research, many of these strategies have been inspired by nature and have taken advantage of physiological processes to achieve brain delivery. Here, the different nanosystems and targeting moieties used to achieve a neuronal delivery reported in the open literature are comprehensively reviewed and critically discussed, with emphasis on the most recent bioinspired advances in the field. Finally, we express our view on the paramount challenges in targeted neuronal delivery that need to be overcome for these promising therapeutics to move from the bench to the bedside.

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“…Thus, P SS C SS LV represent an alternative cellular uptake and cargo delivery system exploiting redox sensitivity similar to disulfide-based and thus reduction-sensitive polymersomes described recently. [28][29][30][31][32] We next examined the cellular delivery of other fluorescently labeled phospholipids incorporated into the redox-responsive P SS C SS LV containers. NBD-PA-containing P SS C SS LV were also efficiently internalized into endosomes from where the NBD-PA was released into the cytosol accumulating in structures at least in part representing ER membranes.…”

mentioning

confidence: 99%

“…This indicates that the polymer shell significantly increases stability and endocytic uptake and that both; a reductively cleavable polymer shell and β‐CD SS core are required for efficient release of labeled phospholipids into the cytosol (Figure ). Thus, P SS C SS LV represent an alternative cellular uptake and cargo delivery system exploiting redox sensitivity similar to disulfide‐based and thus reduction‐sensitive polymersomes described recently …”

mentioning

confidence: 99%

Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers

et al. 2019

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The specific transport of amphiphilic compounds such as fluorescently labeled phospholipids into cells is a prerequisite for the analysis of highly dynamic cellular processes involving these molecules, e.g., the intracellular distribution and metabolism of phospholipids. However, cellular delivery remains a challenge as it should not affect the physiological integrity and morphology of the cell membrane. To address this, polymer nanocontainers based on redox‐responsive cyclodextrin (CD) amphiphiles are prepared, and their potential to deliver fluorescently labeled phospholipids to intracellular membrane compartments is analyzed. It is shown that mixtures of reductively degradable cyclodextrin amphiphiles and different phospholipids form liposome‐like vesicles (CD–lipid vesicles, CSSLV) with a homogeneous distribution of each lipid. Host–guest‐mediated self‐assembly of a cystamine‐crosslinked polymer shell on these CSSLV produces polymer‐shelled liposomal vesicles (PSSCSSLV) with the unique feature of a redox‐sensitive CSSLV core and reductively degradable polymer shell. PSSCSSLV show high stability and a redox‐sensitive release of the amphiphilic cargo. Live cell experiments reveal that the novel PSSCSSLV are readily internalized by primary human endothelial cells and that the reductive microenvironment of the cells' endosomes triggers the release of the amphiphilic cargo into the cytosol. Thus, PSSCSSLV represent a highly efficient system to transport lipid‐like amphiphilic cargo into the intracellular environment.

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Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-S-S-PLA-PCL-OH boost delivery of bacosides to the brain

Cited by 34 publications

References 101 publications

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers

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