Lactoferrin enhances efficacy of the BCG vaccine: comparison between two inbred mice strains (C57BL/6 and BALB/c)

Hwang, Shen An; Arora, Ranjana; Kruzel, Marian L.; Actor, Jeffrey K.

doi:10.1016/s1472-9792(09)70012-5

Cited by 20 publications

(24 citation statements)

References 41 publications

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“…There are multiple studies examining adjuvant/adjunct molecules in combination with BCG to modulate innate responses and modify adaptive function boosting BCG efficacy (174, 178). In particular, lactoferrin, a host-secreted mediator that bridges innate and adaptive immune function in mammals (179), can act as an adjuvant with BCG protecting the lung alveolar integrity upon challenge with M.tb (180, 181). Adjuvants also make subunit vaccines more effective in boosting BCG (174), as a promising example is the IC31 adjuvanted H56 (182).…”

Section: Adjuvants and Bcgmentioning

confidence: 99%

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

2017

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Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), is the current leading cause of death due to a single infectious organism. Although curable, the broad emergence of multi-, extensive-, extreme-, and total-drug resistant strains of M.tb has hindered eradication efforts of this pathogen. Furthermore, computational models predict a quarter of the world’s population is infected with M.tb in a latent state, effectively serving as the largest reservoir for any human pathogen with the ability to cause significant morbidity and mortality. The World Health Organization has prioritized new strategies for improved vaccination programs; however, the lack of understanding of mycobacterial immunity has made it difficult to develop new successful vaccines. Currently, Mycobacterium bovis bacillus Calmette–Guérin (BCG) is the only vaccine approved for use to prevent TB. BCG is highly efficacious at preventing meningeal and miliary TB, but is at best 60% effective against the development of pulmonary TB in adults and wanes as we age. In this review, we provide a detailed summary on the innate immune response of macrophages, dendritic cells, and neutrophils in response to BCG vaccination. Additionally, we discuss adaptive immune responses generated by BCG vaccination, emphasizing their specific contributions to mycobacterial immunity. The success of future vaccines against TB will directly depend on our understanding of mycobacterial immunity.

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Section: Adjuvants and Bcgmentioning

confidence: 99%

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

2017

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“…Namely, it has been used as an effective adjuvant for the BCG vaccine. Lactoferrin enhances the efficacy of this vaccine through induction of Th1 immune responses [39]. …”

Section: Endogenous Antimicrobial Peptides and Their Analogues As Thementioning

confidence: 99%

Endogenous antimicrobial factors in the treatment of infectious diseases

Żelechowska¹,

Agier²,

Brzezińska‐Błaszczyk³

2016

cejoi

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Nowadays, a number of antibiotic-resistant bacteria strains is increasing. It is a serious clinical problem and poses a threat to the effectiveness of conventional antibiotic therapy. Thus, scientists are constantly seeking new alternatives for treatment of infectious diseases. There are some natural endogenous factors, which possess antimicrobial activities against a large number of microorganisms, including both Gram-positive and Gram-negative bacteria, viruses and fungi. These factors are present in all eukaryotic organisms and constitute an essential element of their immune system. A large number of in vitro and in vivo models have been used to show the activity of antimicrobial factors, and only few studies have been conducted on people. Results indicate that administration of these molecules is therapeutically beneficial. This review summarizes knowledge of selected endogenous antimicrobial agents, such as cathelicidins, defensins, histatins, lysozyme and lactoferrin. We also discuss potential uses of these factors in the treatment of infectious diseases.

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“…Despite numerous publications on milk proteins and milk derived peptides with immune regulating activity, there are scarse reports of their adjuvant potential to vaccine. Lactoferrin could function as an effective adjuvant as it has been documented to enhance efficacy of the Bacillus CalmetteGuerin, the current vaccine for tuberculosis disease by promoting host protection and decreasing disease manifestation [201,202]. Additionally, recombinant porcine lactoferrin significantly increased serum IgA, IgG and infectious bursal disease virus-specific antibody, as well as enhanced interferon-and interleukin-12 expressed in chicken T-lymphocytes, suggesting that porcine lactoferrin could enhance cell-mediated immunity and strengthen the ability of vaccinating against infectious bursal disease infection [203,204].…”

Section: Commercial Potential Of Milk Derived Proteins and Peptidesmentioning

confidence: 99%

Milk Derived Peptides with Immune Stimulating Antiviral Properties

Sun¹,

Jenssen²

2012

Milk Protein

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Lactoferrin enhances efficacy of the BCG vaccine: comparison between two inbred mice strains (C57BL/6 and BALB/c)

Cited by 20 publications

References 41 publications

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

Endogenous antimicrobial factors in the treatment of infectious diseases

Milk Derived Peptides with Immune Stimulating Antiviral Properties

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