Lactoferrin induced neuronal differentiation: A boon for brain tumours

Sriramoju, Bhasker; Kanwar, Rupinder K.; Kanwar, Jagat R.

doi:10.1016/j.ijdevneu.2014.12.005

Cited by 21 publications

(15 citation statements)

References 55 publications

(58 reference statements)

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“…Milk consumption increases circulating insulin-like growth factor-1 and there is a positive association between this factor and depression [4]. Moreover, milk proteins such as lactoferrin impact neuronal differentiation [5], while milk whey protein alters brain mitochondrial activity and oxidative stress markers [6]. As these pathways are implicated in depression, we aimed to examine the relationship between milk intake and the risk for de novo MDD.…”

Section: Tablementioning

confidence: 99%

Milk Consumption and the Risk for Incident Major Depressive Disorder

Pasco¹,

Williams²,

Brennan-Olsen³

et al. 2015

Psychother Psychosom

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Section: Tablementioning

confidence: 99%

Milk Consumption and the Risk for Incident Major Depressive Disorder

Pasco¹,

Williams²,

Brennan-Olsen³

et al. 2015

Psychother Psychosom

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“…In addition to serving a key role in immune homeostasis, LF also reduces oxidative stress and may control excessive inflammatory responses (13,15,16). Recently, Sriramoju et al (17) reported that LF exerts various beneficial effects on humans and animals, including inhibition of carcinogenesis and prevention of drug-induced toxicity. Irradiated mice on an LF diet exhibited a significantly higher survival rate compared with mice fed a standard diet (18).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Qin

et al. 2018

Exp Ther Med

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The radioprotective effect of lactoferrin (LF) was studied in mice subjected to sublethal X-ray irradiation. The mice were randomly divided into the Control (non-irradiated mice fed a standard diet without LF), IR (irradiated mice fed a standard diet) and IR+LF (irradiated mice fed LF) groups. The mice were fed daily for 7 days prior to irradiation and for 30 continuous days following irradiation. The survival ratio of the mice in the IR+LF group was significantly increased compared with the IR group between days 15 and 30 after irradiation. The body weight of the mice in the IR+LF group was increased compared with the IR group, and the difference was statistically significant. Blood was collected from the mice via the tail vein on days 2, 7, 14, 21 and 30 following irradiation. The laboratory indicators, including leukocyte, erythrocyte and platelet counts recovered more rapidly following irradiation in the IR+LF group compared with the IR group. Treatment of the irradiated mice with LF significantly reduced the DNA damage. In the hepatic tissue the level of superoxide dismutase in the IR+LF group was significantly increased, while malondialdehyde was significantly decreased compared with the IR group. These findings indicate that LF may prevent radiation damage and may have potential as a treatment for patients with cancer who receive radiotherapy.

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“…2,8–10 In addition, LF has been shown to have anti-angiogenic and anti-tumor properties, and most recently, essential roles in the neuronal differentiation. 2,11 While the mechanism for LF’s multipotency awaits further investigation, there is evidence suggesting that its anti-bacterial effect is conveyed in more than one way. LF confers its bacteriostatic activity on certain iron-dependent bacteria, including Escherichia coli , by sequestering available iron.…”

Section: Introductionmentioning

confidence: 99%

Lactoferrin Expression in Human and Murine Ocular Tissue

Rageh¹,

Ferrington²,

Roehrich

et al. 2015

Current Eye Research

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Purpose Lactoferrin (LF) is a multifunctional protein known to provide innate defense due to its antimicrobial and anti-inflammatory properties. In the eye, LF has been identified in the tears and vitreous humor. Its presence in other ocular tissues has not been determined. Our aim is to assess the presence of LF in the cornea, iris, retina and retinal pigment epithelium (RPE) of humans and mice. Methods To test for the endogenous production of LF, reverse transcription polymerase chain reaction was performed in cultured human cells from the cornea and RPE and in murine tissues. To confirm LF localization in specific ocular tissue, immunohistochemistry was performed on flat mounts of cornea, retina and RPE in human donor eyes. The presence of LF was assessed by western blotting in human and mouse ocular tissue and human culture cells (cornea and RPE). To verify antibody specificity, purified human LF and transferrin (TF) were used on 1D and 2D western blots. Results LF gene expression was confirmed in the cornea and RPE cell cultures from humans, suggesting that LF is an endogenously produced protein. PCR results from mouse ocular tissue showed LF expression in cornea, iris, RPE, but not in retina. These results were also consistent with immunohistochemical localization of LF in human donor tissue. Antibody reaction for human LF was specific and western blotting showed its presence in the cornea, iris and RPE tissues. A faint reaction for the retina was observed but was likely due to contamination from other ocular tissues. Multiple commercially available antibodies for murine LF cross-reacted with TF, so no reliable results were obtained for murine western blot. Conclusion LF is expressed in multiple eye tissues of humans and mice. This widespread expression and multifunctional activity of LF suggests that it may play an important role in protecting eye tissues from inflammation-associated diseases.

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Lactoferrin induced neuronal differentiation: A boon for brain tumours

Cited by 21 publications

References 55 publications

Milk Consumption and the Risk for Incident Major Depressive Disorder

Milk Consumption and the Risk for Incident Major Depressive Disorder

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Lactoferrin Expression in Human and Murine Ocular Tissue

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