Lactose-[13C]Ureide Breath Test: A New, Noninvasive Technique to Determine Orocecal Transit Time in Children

Specific aspects of gastro-intestinal transit in children for drug delivery design

“…However, lactulose increased the intestinal motility through its osmotic effects as was seen by the greater time of 255 min using the lactose 13 C Ureide test in children aged from 3 to 17 years (Van Den Driessche et al, 2000).…”

“…A general overview of how the intestinal characteristics of younger children differ from adults can be seen in Table 3. The choice of test to determine intestinal transit can be dependent upon age: there is a risk of harm by younger infants or neonates attempting to swallow pellets and lactose 13 C Ureide test is unsuitable in infants less than 8 months as they lack the enzyme required to metabolise it (Van Den Driessche et al, 2000). Hence most of the time carmine dye is used as it is easy to administer and appears to be well tolerated in all age groups but it only gives the time taken for the dye to transit from the mouth to excretion in the faeces.…”

Gastrointestinal handling of glycosyl [13C]ureides

“…As a result of the accuracy and precision of the instruments available to analyse breath 13 CO 2 enrichment, only a small amount of tracer is required to enable its detection in breath, thereby circumventing osmotic effects on OCTT. A number of studies have described the use of lactose [ 13 C]ureide ( 13 C LU) in adults (Wutzke et al, 1997;Geypens et al, 1999;Jackson et al, 1999) and children (Van Den Driessche et al, 2000) although relatively few studies have described its metabolism in the small intestine (Ruemmele et al, 1997) and the colon (Mohr et al, 1999).…”

Ontogeny of oral drug absorption processes in children

“…We identified four studies using the hydrogen breath test to measure OCTT in different pediatric age groups [58][59][60][61][62]. The populations were quite heterogeneous, but there does not appear to be an age-related difference in OCTT.…”