Lactose intolerance and cow's milk protein allergy

Rangel, Adriano Henrique do Nascimento; Sales, Danielle Cavalcanti; Urbano, Stela Antas; Júnior, José Geraldo Bezerra Galvão; Neto, Júlio César de Andrade; Macêdo, Cláudia de Souza

doi:10.1590/1678-457x.0019

Cited by 63 publications

(47 citation statements)

References 30 publications

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“…For this reason, equine milk has stood out in treating children who have cow milk protein allergy (CMPA), especially during early childhood. This condition affects 2 to 5% of the children under three years of age (Rangel et al, 2016).…”

Section: Characteristics Of Equine Milk That Make It Suitable For Hummentioning

confidence: 99%

“…The importance of milk in children's nutritional plan is no longer questionable, however the moderate frequency of allergies to cow milk protein, as already highlighted by Rangel et al (2016), instigates the development of studies which may provide alternatives to the problem. On this sense, Businco et al (2000) conducted the pioneering study (in vivo and in vitro) to test the allergenicity of mares' milk in a population of 25 children ranging in age from 19 to 72 months with severe allergy to cow milk protein.…”

Section: Raw Frozen or Powdered Milkmentioning

confidence: 99%

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Equine milk and its potential use in the human diet

et al. 2019

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Dur objective was to address the use of equine milk for human consumption, highlighting important compositional aspects and peculiar characteristics of this milk. Equine milk stands out for its similarity to breastmilk in compositional aspects considering the quality of the protein and lipid fractions, and due to the presence of important bioactive compounds. The high percentage of whey proteins and the structure of the protein micelles favor equine milk's digestibility, while its bioactive protein richness and the good relationships established between fatty acids highlight it as a functional food. Children who are allergic to cow's milk protein, the elderly and/or people affected by skin and gastrointestinal disorders are potential consumer of equine milk. Assays have proven the therapeutic properties of koumiss; high tolerability of equine milk by children who are intolerant to cow's milk; beneficial effects in treating atopic dermatitis and chronic diseases of the gastrointestinal tract; and potential of this milk in the prophylaxis and/or nutritional support of patients affected by several diseases. Scientific findings highlight the potential of equine milk as a beneficial food for human health, regarding both its nutritional aspects and functionalities, which could contribute to the increased demand for equine milk in global dairy market.

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Section: Characteristics Of Equine Milk That Make It Suitable For Hummentioning

confidence: 99%

Section: Raw Frozen or Powdered Milkmentioning

confidence: 99%

Equine milk and its potential use in the human diet

et al. 2019

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“…By consuming the vegetable milk-substitute formulations, particularly soy milk, some of the potentially deleterious aspects of animal products, such as the cholesterol, can be avoided [2]. Moreover, the increasing prevalence of cases of cow's milk protein allergies [3] is another driving factor affecting the adoption of these types of beverages.…”

Section: Introductionmentioning

confidence: 99%

Consumers Preferences for Dairy-Alternative Beverage Using Home-Scan Data in Catalonia

Laassal¹,

Kallas

2019

Beverages

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The changing lifestyles and the growing health concerns towards the negative impact of the saturated fatty acids originating from animals has increased consumers’ preferences for dairy-alternative products. These products belong to the food and beverage classification that is similar to certain types of dairy-based products in terms of texture and flavor, and has similar nutritional benefits. In this context, we seek to identify the willingness to pay (WTP) for the most important attributes that consumers take into account when purchasing the dairy-alternative drinks. A revealed preference discrete choice experiment was carried out using home-scan data belonging to ©Kantar Worldpanel (Barcelona, Spain) regarding the consumption of dairy-alternative drinks in Catalonia (Spain) in 343 households. Furthermore, factors that affect the purchasing frequency of this type of product were analyzed through the Poisson and negative binomial models. Results showed that price was the major driving factor, followed by the original non-dairy beverage flavor attribute. The original non-dairy beverage flavor compared to other added ingredients and tastes showed higher WTP when purchasing the non-dairy alternative. Marketing strategies should promote products by focusing on the “original” and “pure” version of the product without additional ingredients, or through reduction of the undesirable compounds if they exist in these kinds of beverages.

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“…The occurrence of allergy to cow milk proteins is highest in early childhood but later subsides (Jo et al, 2014). The high incidence of milk allergy in children can be attributed to the fact that cow milk proteins are often the first foreign food antigens introduced into a child's diet (Rangel et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Immunoreactive properties of α-casein and κ-casein: Ex vivo and in vivo studies

Fuc

Złotkowska

Stachurska

et al. 2018

Journal of Dairy Science

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The aim of this study was to evaluate the ex vivo and in vivo studies immune potential of α-and κ-casein. Ex vivo, naïve mouse splenocytes were stimulated with α-or κ-casein. After 120 h of culture, the proliferation index (PI), determined by 3-(4,5 dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and carboxyfluorescein diacetate N-succinimidyl ester (CFSE) staining, did not vary for either antigen, suggesting similar ex vivo immunogenic potential of both casein fractions. In vivo, BALB/ccmdb mice were sensitized with α-or κ-casein and then gavaged with primary antigen. Mice immunized with α-casein had higher levels of IgG (2 16.33) and IgA (2 10.22) in serum at the end of the experiment compared with mice immunized with κ-casein (2 15 and 2 9.3 for IgG and IgA, respectively). The use of α-casein for mouse immunization and ex vivo lymphocyte stimulation resulted in higher concentrations of secreted cytokines (IL-4, IL-10) compared with κ-casein stimulation. This is consistent with increasing regulatory T cell (Treg) lymphocyte populations, independent of the antigen used for stimulation. In summary, the immunogenic potential of α-and κ-casein was similar. Humoral and cellular immune responses confirmed their strong, independent potential to induce B and T cells. We propose that the lymphocyte proliferation index be used as an initial screening for protein immunogenicity.

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Lactose intolerance and cow's milk protein allergy

Cited by 63 publications

References 30 publications

Equine milk and its potential use in the human diet

Equine milk and its potential use in the human diet

Consumers Preferences for Dairy-Alternative Beverage Using Home-Scan Data in Catalonia

Immunoreactive properties of α-casein and κ-casein: Ex vivo and in vivo studies

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