LADA prevalence estimation and insulin dependency during follow‐up

Park, Yong Soo; Hong, Sangmo; Park, Leejin; Woo, J.; Baik, Sehyun; Nam, M.; Lee, Kwan‐Woo; Kim, Youngseol

doi:10.1002/dmrr.1278

Cited by 36 publications

(46 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is contrary to the findings observed in China and Europe, where compared to north, the frequency of LADA was lower in the southern region [9,18,[39][40][41][42]. Interestingly, lower frequency of LADA 2.6% was noted in an island nation Srilanka near southern coast of India [43].…”

Section: Discussioncontrasting

confidence: 73%

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Kumar¹,

Leiva²

2017

JED

View full text Add to dashboard Cite

Aims: We undertook a study to investigate the prevalence and general characteristics of patients with Latent autoimmune diabetes in adults (LADA).Methods: This was a cross-sectional investigation conducted in the National Capital Region of India. Total of 139 subjects were recruited in the study. All subjects were screened for Glutamic acid decarboxylase autoantibody (GADA). GADA was analysed using ELISA kits with 98% specificity and 92% sensitivity. Results:The prevalence of LADA was 6.5% (6.3% in men and 6.8% in women); 95% Confidence interval (CI): 3.29 -12.0% among adult-onset diabetic patients. Prevalence of LADA seemed to gradually decline with increasing age. LADA (n=9) and DM2 (n=130) patients were compared. LADA patients were younger (p = 0.045), had lower age at onset of diabetes (p = 0.025), waist circumference (p = 0.021). LADA patients had also longer duration of diabetes (p = 0.045). There was no significant difference in BMI between two groups. Conclusions:Our results indicate that LADA represents 6.5 % of cases among adult-onset diabetes in a region of north India. LADA is a prevalent form of adult-onset autoimmune diabetes and not rare. This study shows different phenotypic features of LADA patients compared to DM2 patients. In the developing world, sometimes routine antibody testing may be considered not to be cost-effective. Thus, clinical and phenotypic features of LADA may help clinicians recognize patients for potential antibody screening.

show abstract

Section: Discussioncontrasting

confidence: 73%

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Kumar¹,

Leiva²

2017

JED

View full text Add to dashboard Cite

show abstract

“…First, the overall GADA frequency and LADA frequency in China is lower than reported in northern European multicenter studies such as the UK Prospective Diabetes Study (UKPDS) (11) or the Botnia Study (15) but slightly higher than reported in some southern European studies such as the Non–Insulin Requiring Autoimmune Diabetes (NIRAD) study (18), Asian studies for Japanese or Korean (28,29), or the North American/Northern European ADOPT (A Diabetes Outcome Progression Trial) (30). That the frequency of LADA in China is higher than in some European countries is surprising given the infrequency of childhood-onset autoimmune diabetes in China (6,8).…”

Section: Discussionmentioning

confidence: 76%

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study)

et al. 2013

View full text Add to dashboard Cite

Adult non–insulin requiring diabetes includes latent autoimmune diabetes of adults (LADA), distinguished from type 2 diabetes by the presence of islet autoantibodies. LADA China determined the characteristics of Chinese LADA. This nationwide, multicenter, clinic-based cross-sectional study was conducted in 46 university-affiliated hospitals in 25 Chinese cities. All 4,880 ketosis-free diabetic patients (<1 year postdiagnosis, without insulin therapy for >6 months, aged ≥30 years) had GAD antibody (GADA) and HLA-DQ genotype measured centrally with clinical data collected locally. GADA-positive subjects were classified as LADA. Of the patients, 5.9% were GADA positive with LADA. LADA showed a north-south gradient. Compared with GADA-negative type 2 diabetes, LADA patients were leaner, with lower fasting C-peptide and less metabolic syndrome. Patients with high GADA titers are phenotypically different from those with low GADA titers, while only a higher HDL distinguished the latter from those with type 2 diabetes. HLA diabetes–susceptible haplotypes were more frequent in LADA, even in those with low-titer GADA. HLA diabetes-protective haplotypes were less frequent in LADA. Our study implicates universal immunogenetic effects, with some ethnic differences, in adult-onset autoimmune diabetes. Autoantibody positivity and titer could be important for LADA risk stratification and accurate therapeutic choice in clinical practice.

show abstract

“…It has also been reported that patients with low titres (<10 U) of anti‐GAD Ab exhibit significantly higher C‐peptide levels than those with high titres (≥10 U); there were no insulin‐users among participants with low titres of anti‐GAD Ab . Another follow‐up study of Korean patients reported that only 3 of 39 patients who were initially classified as having late autoimmune diabetes in adults (LADA) became insulin‐dependent after 36 months; these 3 patients were all positive for multiple autoantibodies (GAD, islet antigen 2, and zinc transporter 8 antibody). These authors suggested that the baseline titres of anti‐GAD Ab in the patients who required insulin were significantly higher than those who did not and that low anti‐GAD Ab titres or the exclusive presence of GAD Ab characterizes patients with LADA with clinical characteristics that are more similar to patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Long‐term effects on glycaemic control and β‐cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial

Chon

Rhee

Ahn

et al. 2018

Diabetes Obesity Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

LADA prevalence estimation and insulin dependency during follow‐up

Cited by 36 publications

References 29 publications

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study)

Long‐term effects on glycaemic control and β‐cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial

Contact Info

Product

Resources

About