‘Lady Windermere's counterpart? Pulmonary nontuberculous mycobacteria in men with bronchiectasis

Ku, Jennifer; Ranches, Gregory; Siegel, S.A.R.; Winthrop, Kevin

doi:10.1016/j.diagmicrobio.2019.114916

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…In contrast, the fibro-cavitary form of NTM pulmonary disease is considered a phenotype in men with COPD [ 28 ]. However, previous reports suggest a similar NTM phenotype between men and women [ 29 , 30 ]. Although we could not confirm the phenotype in our study, we did not identify a significant difference in the distribution of comorbidities related to NTM infection between men and women.…”

Section: Discussionmentioning

confidence: 91%

Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database

et al. 2022

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Background The global prevalence and incidence of nontuberculous mycobacteria (NTM) infection are increasing. However, the prevalence of NTM infection-associated comorbidities remains understudied. Thus, we investigated the comorbidities associated with NTM infection using the National Health Insurance Service-National Sample Cohort (NHIS–NSC) 2.0 database of the National Health Insurance Service (NHIS). Methods In this case–control study, patients with NTM infection and controls aged 20–89 years of age were matched 1:4 by sex, age, region, and income. A total of 26 comorbidities were selected based on previous reports and claims data analysis. The distribution of comorbidities was compared between patients with NTM infection and controls by sex and age using logistic regression analysis. Results In total, 893 patients (379 men and 514 women) with NTM infection (mean age, 56.1 years) and 3,572 controls (mean age, 55.6 years) were included. The odds ratio for prevalence of respiratory diseases, metabolic diseases, musculoskeletal disorders, gastrointestinal diseases, skin diseases, mental diseases, and neoplasms was significantly higher in patients with NTM infection than in the control group. Among comorbid diseases, the odds ratios (ORs) for the prevalence of the respiratory diseases such as bronchiectasis (OR [95% confidence interval (CI)]: 26.79 [19.69–36.45]) and interstitial pneumonitis (OR [95% CI]: 15.10 [7.15–31.89]) were the highest. No significant differences were observed in NTM infection-related comorbidities between men and women. In the younger age group (20–39 years old), the prevalence of respiratory and systemic diseases such as hypertension and diabetes was higher in the patient group than in the control group. Conclusions NTM infection is associated with several respiratory and systemic diseases that should be considered when providing medical care to patients with NTM infection.

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Section: Discussionmentioning

confidence: 91%

Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database

et al. 2022

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“…There is a growing number of evidence that some individuals are predisposed to Lady Windermere syndrome including tall, thin, white elderly women without previous lung disease [3,4]. However, some reports pointed out male counterparts for this nontuberculous mycobacterial lung disease [5,6]. In addition, some risk factors have been identified including scoliosis, joint hypermobility, and chest wall pectus abnormalities [3,4,7].…”

Section: Introductionmentioning

confidence: 99%

Lady Windermere syndrome: Reality or myth?

Adhikari¹,

DaSilva²,

Madala³

et al. 2022

Case Rep Int

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Introduction: Mycobacterium avium complex (MAC) is a saprophytic bacterium which can cause pulmonary infection in patients with immunocompromised and structural lung disease. Infection in elderly, non-smoker and healthy women affecting right middle lobe is often referred as Lady Windermere syndrome.Case Report: We present a case of an 80-year-old woman who presented with progressive worsening shortness of breath and cough and was found to have MAC infection. It is believed that voluntary cough suppression is a possible cause for the colonization and infection by MAC but our patient did not have this habit. Our patient chose not to get treated and she did relatively well without treatment. Conclusion:Mycobacterium avium complex infection can occur in non-smoker with underlying lung conditions. There are guidelines for management of MAC pulmonary infection with multiple antibiotics and prolonged course and shared decision is recommended prior to initiation of the treatment.

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Nontuberculous Mycobacteria

Varley

Winthrop

2022

Clinics in Chest Medicine

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‘Lady Windermere's counterpart? Pulmonary nontuberculous mycobacteria in men with bronchiectasis

Cited by 7 publications

References 12 publications

Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database

Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database

Lady Windermere syndrome: Reality or myth?

Nontuberculous Mycobacteria

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