1978
DOI: 10.1016/s0040-4039(01)91566-7
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Laevigatin, a sesquiterpenoid furan from lam.

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1984
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Cited by 15 publications
(4 citation statements)
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“…Naphthofuran nuclei are key structural moieties found in a large number of biologically important natural products. Many of the natural naphthofurans, such as (±)-laevigatin [7], (+)-heritol [8, 9] and balsaminone A [10], possess interesting pharmacological and cytotoxic properties [11]. A large number of naphthofuran derivatives are endowed with various biological activities like anthelmintic, anticonvulsant, and antipyretic [12] and their plant extracts are being used for traditional medicines [13], while mansonone D and Dunnione [14] of naphthofuran family are vital biologically active agents.…”
Section: Introductionmentioning
confidence: 99%
“…Naphthofuran nuclei are key structural moieties found in a large number of biologically important natural products. Many of the natural naphthofurans, such as (±)-laevigatin [7], (+)-heritol [8, 9] and balsaminone A [10], possess interesting pharmacological and cytotoxic properties [11]. A large number of naphthofuran derivatives are endowed with various biological activities like anthelmintic, anticonvulsant, and antipyretic [12] and their plant extracts are being used for traditional medicines [13], while mansonone D and Dunnione [14] of naphthofuran family are vital biologically active agents.…”
Section: Introductionmentioning
confidence: 99%
“…Efforts to identify predominant secondary metabolites in Chromolaena have been undertaken. As a result, a large number of such metabolites has been reported, including sesquiterpenes, triterpenes [8], and cadinenes, which have been identified in almost a third of the species of this genus, thus being regarded as genus-specific metabolites [9]. Furthermore, polyhydroxylated and polymethoxylated flavone and flavanones, chalcone-type metabolites, phenolic acids, and coumarins are metabolites with high occurrence in the genus [10].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the synthesis of various derivatives of naphtho [2,1-b]furan was taken up in our laboratory [1][2][3][4] in search of new biologically and pharmacologically active heterocyclic compounds. Many of the natural naphthofurans, such as (±)-Laevigatin [5,6] (1), (+)-Heritol [7][8][9] (2) and Balsaminone A, [10] (3), (Figure 1) possess interesting pharmacological and cytotoxic properties. Several synthetic compounds containing this ring skeleton are associated with diverse biological activities such as antifungal, antibacterial [11,12], antiviral [13], antitumor [14], anthelmintic [15], anti-trypanosomal and cytotoxicity [16].…”
Section: Introductionmentioning
confidence: 99%