Lafora's disease

Cajal, S. Ramón y; Blanes, Àlvar Peris; Martinez, A. J.; Saenz, E. Muñoz; Gutiérrez, Marina

doi:10.1007/bf00688920

Cited by 19 publications

(2 citation statements)

References 21 publications

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“…Even then, it is recognized that the primary substrates of structural plasticity are dendritic spines, neuronal structures which hold most synapses in the brain. Spines were described more than a century ago as small protrusions at the dendritic surface [40]. These micrometer-sized structures are specialized for receiving synaptic afferents and accordingly, they cover the dendrites of many neurons at a high density.…”

Section: Targets Of Pp1 In Long-term Potentiation (Ltp) and Long-termmentioning

confidence: 99%

The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity

MUNTON¹

2004

FEBS Letters

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Synaptic plasticity is a phenomenon contributing to changes in the efficacy of neuronal transmission. These changes are widely believed to be a major cellular basis for learning and memory. Protein phosphorylation is a key biochemical process involved in synaptic plasticity that operates through a tight balance between the action of protein kinases and protein phosphatases (PPs). Although the majority of research in this field has concentrated primarily on protein kinases, the significant role of PPs is becoming increasingly apparent. This review examines one such phosphatase, PP1, and highlights recent advances in the understanding of its intervention in synaptic and structural plasticity and the mechanisms of learning and memory.

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Section: Targets Of Pp1 In Long-term Potentiation (Ltp) and Long-termmentioning

confidence: 99%

The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity

MUNTON¹

2004

FEBS Letters

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“…In 1903 the Spanish neurobiologist Ramón y Cajal found a new structure in nuclei of vertebrate neurons, which, because of its close association with the nucleolus, he named the accessory body (cuerpo accesorio) [1]. Structures that are now known to share essential features with Cajal's accessory body were described during the following decades from a variety of cell types and organisms, ranging from insect and amphibian oocytes to mammalian somatic tissues, cultured cells, and plants.…”

Section: Introductionmentioning

confidence: 99%

A role for Cajal bodies in assembly of the nuclear transcription machinery

Gall

2001

FEBS Letters

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Cajal bodies (CBs) are small nuclear organelles that contain the three eukaryotic RNA polymerases and a variety of factors involved in transcription and processing of all types of RNA. A number of these factors, as well as subunits of polymerase (pol) II itself, are rapidly and specifically targeted to CBs when injected into the cell. It is suggested that pol I, pol II, and pol III transcription and processing complexes are preassembled in the CBs before transport to the sites of transcription on the chromosomes and in the nucleoli.

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Periodic acid-Schiff(PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown

et al. 1995

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Periodic acid-Schiff (PAS)-positive deposits have been demonstrated in the central nervous system (CNS) of patients suffering from a wide variety of neurodegenerative disorders including Alzheimer's disease, presenile dementia, Parkinson's disease, diabetes mellitus, myoclonic epilepsy, and cerebral palsy. The etiology of these deposits and their relationship to mechanisms of progressive neurodegeneration is unknown. In the present study, we demonstrate that the kainic acid model of limbic status epilepticus provides a useful system for the study of PAS-positive staining. The relationship between PAS-positive deposition, induction of fos-like immunoreactivity (FLI), neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown following the kainic acid induction of status epilepticus was investigated. Epileptiform activity was elicited in rats by intraperitoneal administration of 10 mg/kg kainic acid and brains were examined 3, 5, 12, 24, 72, and 168 h after drug injection. Four distinct types of PAS-positive staining in rat brain were observed: type 1, extracellular matrix (ECM) or blood vessel associated-material; type 2, granular deposits; type 3, glial labelling; and type 4, neuronal labelling. Results demonstrated that the four types of PAS-positive staining were differentially associated with specific markers of neuropathology: (1) type 1 ECM staining and type 3 glia were preferentially localized to edematous tissue; (2) the majority of type 3 glia were identified as reactive astrocytes, while a minority of appeared to be proliferating microglia; (3) type 1 blood vessels labelled hemorrhaging vasculature; (4) early deposition of type 2 granules was predictive of subsequent cell loss; (5) chronic type 2 granular deposits and type 4 neuronal labelling not associated with cell death could be predicted by early changes in FLI; and (6) chronic deposition of all four forms of PAS-positive material was correlated with earlier, transient blood-brain barrier compromise. The results support the growing literature that local carbohydrate metabolism may be one of a constellation of parameters important to the development of progressive neurodegeneration.

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Lafora's disease

Cited by 19 publications

References 21 publications

The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity

The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity

A role for Cajal bodies in assembly of the nuclear transcription machinery

Periodic acid-Schiff(PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown

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