Lagenaria siceraria: A Potential Source of Anti-Hyperlipidemic and Other Pharmacological Agents

Background:Due to sedentary lifestyle and stress, the incidence of metabolic disorders are increasing day by day. Among these polycystic ovarian syndrome (PCOS) is an intricate disorder affecting 4%–8% women in their reproductive age and related to ovarian dysfunction characterized by obesity, oligomenorrhea, anovulation and hyperandrogenism. In modern system of medicine, the available allopathic regimen has its own limitations, so it is need of time to find a safe and effective alternative therapy for such type of condition. The most common symptom in 85%–90% of PCOS patients is oligomenorrhea which can be correlated to Artava Kshaya (loss of menstrual fluid) in Ayurveda. Hence, in the present clinical study, Vamana Karma (therapeutic vomiting) with Ikshwaaku seed formulation followed by Shatapushpadi Ghanavati was planned.Aims:To evaluate the efficacy of Vamana Karma (therapeutic vomiting) followed by Shatapushpadi Ghanavati in the management of Aartava Kshaya (loss of menstrual fluid) w. s. r to PCOS.Materials and Methods:A total of 15 patients of PCOS were clinically diagnosed and treated by Vamana Karma (therapeutic vomiting) procedure with Ikshwaaku seed formulation. After completion of Vamana Karma (therapeutic vomiting) and Samsarjana Krama, (post therapy dietary regimen for revival) Shatapushpadi Ghanavati 2 Vati (each 500 mg) twice in a day with lukewarm water was given for 45 days. After completion of 2-month trial, assessment of therapy was estimated by subjective and objective parameters.Results:Statistically extremely significant (P < 0.0001) results were found in menstrual irregularities, obesity, and body mass index. The significant result in reduction of nondominant follicles (P = 0.01 and 0.03 for right and left ovary, respectively), lowering the fasting blood sugar level (P = 0.02) and hirsutism (P = 0.03) was found.Conclusion:Vamana Karma (therapeutic vomiting) followed by Shatapushpadi Ghanavati is very effective in the management of obese PCOS patients and increasing chances of conception.

show abstract

“…In support to this, advanced researches show that Ikshwaku has lipid-lowering, hypoglycemic effect. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of Vamana Karma with Ikshwaaku Beeja Yoga followed by Shatapushpadi Ghanavati in the management of Artava Kshaya w. s. r to polycystic ovarian syndrome

Bhingardive

Sarvade

Bhatted

2017

AYU

View full text Add to dashboard Cite

show abstract

“…Novos usos para a espécie, como os relatados em KATARE et al (2011), são necessários a fi m de minimizar os descartes de subprodutos gerados pela sua produção e industrialização, em especial as sementes. Segundo SANTOS et al (2010), cada fruto tem, em média, 100g de sementes.…”

unclassified

Composição centesimal e perfil dos ácidos graxos de sementes de porongo

2014

View full text Add to dashboard Cite

RESUMO O fruto do porongueiro se destina à fabricação de cuias, utensílios e artesanatos. Em regiões produtoras comerciais C18: 2, omega-6), palmitic acid (C16: 0), oleic (C18: 1, omega-9) and stearic acid (C18: 0). The results of centesimal composition and profi le of fatty acids suggest a nutritional potential that needs to be better studied with a view to exploiting the bottle gourd seeds.

show abstract

Anticlastogenic activity of ethanolic extract of Lagenaria siceraria fruit (ELSF) against cyclophosphamide induced genotoxicity in mice

Kolure,

Penumallu,

Thakur

et al. 2024

Discov Appl Sci

View full text Add to dashboard Cite

To investigate the potential of ethanolic extracts of Lagenaria siceraria fruit (ELSF) in protecting against cyclophosphamide (CP)—induced genotoxicity in Swiss albino mice. The study used a pre-treatment approach with ELSF given orally to the animals at two different doses (100 and 200 mg/kg) for 14 days straight. The CP induction group was given prior treatment for 14 days with ELSF (100 and 200 mg/kg) and the positive control group received an i.p (single intraperitoneal) cyclophosphamide dose (40 mg/kg) as the induction agent. The frequency of CP-induced micronuclei and damage to DNA was assessed as hallmark in bone marrow cells isolated form mouse. Study findings revealed that ELSF pre-treatment significantly lowered the frequency of CP-induced micronuclei and DNA damage in mouse bone marrow cells. The suppression effect as protectant was observed at both doses of ELSF (100 and 200 mg/kg). The study demonstrated that ELSF has potential chemoprotective properties against CP-induced genotoxicity. The findings suggest that ELSF could be a natural and safe approach to protecting healthy cells from the harmful effects of chemotherapy. Further clinical investigation warrants the ameliorative potential of ELSF in cancer treatment. Graphical abstract

show abstract

Lagenaria siceraria: A Potential Source of Anti-Hyperlipidemic and Other Pharmacological Agents

Cited by 6 publications

References 0 publications

Clinical efficacy of Vamana Karma with Ikshwaaku Beeja Yoga followed by Shatapushpadi Ghanavati in the management of Artava Kshaya w. s. r to polycystic ovarian syndrome

Clinical efficacy of Vamana Karma with Ikshwaaku Beeja Yoga followed by Shatapushpadi Ghanavati in the management of Artava Kshaya w. s. r to polycystic ovarian syndrome

Composição centesimal e perfil dos ácidos graxos de sementes de porongo

Anticlastogenic activity of ethanolic extract of Lagenaria siceraria fruit (ELSF) against cyclophosphamide induced genotoxicity in mice

Contact Info

Product

Resources

About