Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats

He, Junwei; Zhang, Qingcui; Xia, Xiaoyi; Yang, Li

doi:10.1016/j.phymed.2023.155050

Cited by 7 publications

(1 citation statement)

References 58 publications

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“…Inflammation of the blood vessels generally triggers the activation of endothelial cells, platelets, and leukocytes, leading to endothelial dysfunction and blood clot formation [33,35]. Endothelial dysfunction suppresses eNOS activity and NO production while inducing the expression of adhesion molecules, such as ICAM-1, VCAM-1, and P-selectin, to promote the adhesion of monocytes and platelets to the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Antarctic Krill Oil from Euphausia superba Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model

Lee,

Chae

et al. 2023

IJMS

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FJH-KO obtained from Antarctic krill, especially Euphausia superba, has been reported to contain high amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and to exhibit anticancer and anti-inflammatory properties. However, its antithrombotic effects have not yet been reported. This study aimed to investigate the antithrombotic effects of FJH-KO in carrageenan-induced thrombosis mouse models and human endothelial cells. Thrombosis was induced by carrageenan injection, whereas the mice received FJH-KO pretreatment. FJH-KO attenuated carrageenan-induced thrombus formation in mouse tissue vessels and prolonged tail bleeding. The inhibitory effect of FJH-KO was associated with decreased plasma levels of thromboxane B2, P-selectin, endothelin-1, β-thromboglobulin, platelet factor 4, serotonin, TNF-α, IL-1β, and IL-6. Meanwhile, FJH-KO induced plasma levels of prostacyclin I2 and plasminogen. In vitro, FJH-KO decreased the adhesion of THP-1 monocytes to human endothelial cells stimulated by TNF-α via eNOS activation and NO production. Furthermore, FJH-KO inhibited the expression of TNF-α-induced adhesion molecules such as ICAM-1 and VCAM-1 by suppressing the NF-κB signaling pathway. Taken together, our study demonstrates that FJH-KO protects against carrageenan-induced thrombosis by regulating endothelial cell activation and has potential as an antithrombotic agent.

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Section: Discussionmentioning

confidence: 99%